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Article Dans Une Revue Current Opinion in Microbiology Année : 2013

Innate receptors for adaptive immunity

Résumé

Pattern recognition receptors (PRRs) are commonly known as sensor proteins crucial for the early detection of microbial or host-derived stress signals by innate immune cells. Interestingly, some PRRs are also expressed and functional in cells of the adaptive immune system. These receptors provide lymphocytes with innate sensing abilities; for example, B cells express Toll-like receptors, which are important for the humoral response. Strikingly, certain other NOD-like receptors are not only highly expressed in adaptive immune cells, but also exert functions related specifically to adaptive immune system pathways, such as regulating antigen presentation. In this review, we will focus particularly on the current understanding of PRR functions intrinsic to B and T lymphocytes; a developing aspect of PRR biology.

Dates et versions

hal-01911445 , version 1 (02-11-2018)

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Marie-Cécile Michallet, Giorgia Rota, Kendle Maslowski, Greta Guarda. Innate receptors for adaptive immunity. Current Opinion in Microbiology, 2013, 16 (3), pp.296-302. ⟨10.1016/j.mib.2013.04.003⟩. ⟨hal-01911445⟩
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