The CONSTANCES cohort, an epidemiological research infrastructure. Methods and results of the pilot phase - CONSulTANts des CES-Centres d'examens de santé Accéder directement au contenu
Article Dans Une Revue EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH Année : 2013

The CONSTANCES cohort, an epidemiological research infrastructure. Methods and results of the pilot phase

Sébastien Bonenfant
  • Fonction : Auteur
Matthieu Carton
Mireille Coeuret-Pellicer
  • Fonction : Auteur
Alice Guéguen
  • Fonction : Auteur
Julie Gourmelen
  • Fonction : Auteur
Stéphane Le Got
  • Fonction : Auteur
Sylvie Lemonnier
  • Fonction : Auteur
Mélissa Nachtigal
  • Fonction : Auteur
Anna Ozguler
  • Fonction : Auteur
Ariane Quesnot
  • Fonction : Auteur
Céline Ribet
  • Fonction : Auteur
Annie Rudnicki
  • Fonction : Auteur
Angel Serrano
  • Fonction : Auteur
Annie Schmaus
  • Fonction : Auteur

Résumé

Background: prospective cohorts represent an essential design for epidemiological studies and allow for the study of the combined effects of lifestyle, environment, genetic predisposition, and other risk factors on a large variety of disease endpoints. The CONSTANCES cohort is intended to provide public health information and to serve as an epidemiological research infrastructure accessible to the epidemiologic research community. Although designed as a “general-purpose” cohort with very broad coverage, it will particularly focus on occupational and social determinants of health, and on chronic diseases and aging. Methods: the CONSTANCES cohort is designed as a randomly selected representative sample of French adults aged 18-69 years at inception; 200 000 subjects will be included over a five-year period. At inclusion, the selected subjects are invited to fill a questionnaire and to attend a Health Screening Center (HSC) for a comprehensive health examination: weight, height, blood pressure, electrocardiogram, vision, auditory, spirometry, and biological parameters; for those aged 45 years and older, a specific work-up of functional, physical, and cognitive capacities is performed. A biobank will be set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and work-related events and health data are collected from the French national retirement, health and death databases. The data include social and demographic characteristics, socioeconomic status, life events, behaviors, and occupational factors. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To take into account non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants was set up and will be followed through the same national databases as participants. Results: a field-pilot was performed in 2010 in seven HSCs, which included about 3 500 subjects; it showed a satisfactory structure of the sample and a good validity of the collected data. Conclusions: the constitution of the full eligible sample begun in 2012 and the cohort will be completed by the end of 2017. A public call for ancillary research projects will be launched in 2014
Fichier principal
Vignette du fichier
galimberti,+8921-12945-2-PB.pdf (1.25 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
licence : CC BY - Paternité

Dates et versions

hal-03595043 , version 1 (06-06-2023)

Identifiants

Citer

Marie Zins, Lisa F Berkman, Marcel Goldberg, Sébastien Bonenfant, Matthieu Carton, et al.. The CONSTANCES cohort, an epidemiological research infrastructure. Methods and results of the pilot phase. EPIDEMIOLOGY BIOSTATISTICS AND PUBLIC HEALTH, 2013, 10 (3), pp.e 8 9 2 1. ⟨10.2427/8921⟩. ⟨hal-03595043⟩
27 Consultations
11 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More