BCL-2 proteins in senescence: beyond a simple target for senolysis?
Abstract
BCL-2 and related proteins are major regulators of apoptosis that have emerged as promising targets for the elimination senescent cells (or ‘senolysis’) to improve age-related diseases and promote healthy ageing. However, seminal observations and recent findings shed light on non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence.
Domains
Biochemistry, Molecular Biology
Origin : Files produced by the author(s)