Journal Articles European Journal of Cancer Year : 2024

Cancer immunotherapy in elderly patients: the concept of immune senescence challenged by clinical experience

Abstract

Cancer immunotherapy, including immune checkpoint inhibitors, chimeric antigen receptor T-cell therapy and bispecific antibodies, has led to major improvements in the treatment of a wide range of hematologic malignancies and solid tumors. However, age-mediated immune system modifications, known as immunosenescence, may preclude its efficacy in elderly patients. In this review, we assessed the efficacy of these different cancer immunotherapies in elderly patients compared to young patients to revisit the concept of immunosenescence from a therapeutic perspective.
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Avant la publication
Friday, May 23, 2025
Embargoed file
Friday, May 23, 2025
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hal-04891566 , version 1 (20-01-2025)

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Mathilde Guégan, Malvina Bichon, Nathalie Chaput, Roch Houot, Jean Lemoine. Cancer immunotherapy in elderly patients: the concept of immune senescence challenged by clinical experience. European Journal of Cancer, 2024, 214, pp.115145-115145. ⟨10.1016/j.ejca.2024.115145⟩. ⟨hal-04891566⟩
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