Journal Articles (Review Article) British Journal of Pharmacology Year : 2025

Cathepsins: Novel opportunities for antibody therapeutics in cancer

Abstract

Cathepsins, the most abundant lysosomal proteases, have key functions in cell maintenance and homeostasis. They are overexpressed and hypersecreted in cancer and associated with poor prognosis. Secreted cathepsins display pro‐tumour activities in the tumour microenvironment and thus represent interesting molecular targets in oncology. Recently, several antibody‐based cancer therapies have targeted the pro‐tumour activity of the extracellular cathepsin pool, altering several cancer hallmarks, but not the intracellular cathepsin levels that are often crucial for cell homeostasis. In this mini‐review, we describe advances in antibodies against extracellular cathepsins in cancer, and their effect on the proteolytic cascade, matrix remodelling, proliferation, and modulation of the anti‐cancer immune response. We also discuss the add‐on value of combination strategies (anti‐cathepsin antibodies with chemotherapy and/or biologics) that make anti‐cathepsin antibodies a new opportunity for disease management.
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Avant la publication
Monday, July 21, 2025
Embargoed file
Monday, July 21, 2025
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hal-04903563 , version 1 (21-01-2025)

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Timothée David, Pénélope Desroys Du Roure, Aude Mallavialle, Valérie Laurent-Matha, Pascal Roger, et al.. Cathepsins: Novel opportunities for antibody therapeutics in cancer. British Journal of Pharmacology, inPress, ⟨10.1111/bph.17437⟩. ⟨hal-04903563⟩
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