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Hdr Année : 2022

Mechanical phenotyping of cells in microsystems to detect pathologies

Phénotypage mécanique de cellules en microsystème pour la détection de pathologies

Magalie Faivre

Résumé

Indeed various pathologies and modifications of cell states are reported to influence cell mechanical properties. For example, variation of Red Blood Cells deformability is associated with malaria, white blood cells deformability varies in sepsis and acute respiratory distress syndrome, increase deformability of metastatic cancer cells have been observed, finally drop of stiffness during stem cell differentiation have been highlighted. A better understanding of cell deformability and its interactions with physical environment may imply enormous developments in disease diagnostics, therapeutics and drug screening assays. For the past 10 years, my work has been structured around the development of microfluidic tools dedicated to 2 different cell types: - The characterization of adherent cells migrating on a substrate was addressed using innovative approaches, combining mechanical and migratory properties of cancer cells. - Circulating cells, passively carried by the flow, have been studied through the detection and therapeutic followup of malaria and the relationship between chemotherapy resistance and mechanical response of acute myeloid leukemia cells.
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tel-03830595 , version 1 (26-10-2022)

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  • HAL Id : tel-03830595 , version 1

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Magalie Faivre. Mechanical phenotyping of cells in microsystems to detect pathologies. Micro and nanotechnologies/Microelectronics. Université Claude Bernard - Lyon 1, 2022. ⟨tel-03830595⟩
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