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Article Dans Une Revue Scientific Reports Année : 2016

Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins

Résumé

A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus (HCV) at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized, based on a limited set of protein sequences with high sequence identity within genotypes. The identified coevolving residues constitute highly relevant predictions of protein-protein interactions for further experimental identification of HCV protein complexes. The method can be used to analyse other viral genomes and to predict the associated protein interaction networks.
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hal-01320023 , version 1 (23-05-2016)

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Raphaël Champeimont, Elodie Laine, Shuang-Wei Hu, Francois Penin, Alessandra Carbone. Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins. Scientific Reports, 2016, 6, pp.26401. ⟨10.1038/srep26401⟩. ⟨hal-01320023⟩
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