Antioxidative and wound healing properties of Crateva adansonii DC
Résumé
Leaves of Crateva adansonii DC, a small bush found in Togo, are widely used in traditional medicine to cure infectious abscess. Traditional healers harvest only young leaves and sprouts early in the morning in order to prepare their drugs. To validate this ancestral practice, we performed a phytochemical screening of various C. adansonii leaves samples collected in different places, at different time and at different ages.
Using antioxidant activity as selection criteria, optimal extracts were obtained with sprout leaves, collected at 5:00 am in Djidjolé. Wound healing potential was then investigated for several extracts in vitro on keratinocytes stimulated by Staphylococcus aureus proteins. Anti-inflammatory activity was highlighted with flavonoids-rich extracts, especially against TNFa. Those results validate the traditional practices and the potential of C. adansonii as wound healing drug.
Domaines
Sciences du Vivant [q-bio]
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Poster_Boudesocque_7-Int-Conf-Polyphenols-Health_2015_P1022_1.pdf (882.75 Ko)
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