Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Accéder directement au contenu
Poster De Conférence Année : 2015

Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli

Résumé

A high prevalence of the adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn's disease patients has been shown. We previously showed that upon AIEC infection, autophagy is induced in host cells to restrain AIEC intracellular replication. The mechanism underlying such autophagy induction, however, remains largely unknown. Here, we investigated the role of the GCN2/eIF2α/ATF4 pathway in autophagy response to AIEC infection.
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Dates et versions

hal-02740431 , version 1 (02-06-2020)

Identifiants

  • HAL Id : hal-02740431 , version 1
  • PRODINRA : 324436
  • WOS : 000353811200121

Citer

A. Bretin, J. Carrière, Marion Dalmasso, N. Barnich, A. Bergougnoux, et al.. Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli. 10. Congress of ECCO. Inflammatory Bowel Diseases, Feb 2015, Barcelone, Spain. , Journal of Crohn's and Colitis, 9, 2015, 10th Congress of ECCO. Inflammatory Bowel Diseases. ⟨hal-02740431⟩
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