L. Abramson, S. Wirick, C. Lee, C. Jacobsen, and J. A. Brandes, The use of soft X-ray spectromicroscopy to investigate the distribution and composition of organic matter in a diatom frustule and a biomimetic analog, Deep Sea Research Part II: Topical Studies in Oceanography, vol.56, issue.18, pp.1369-1380, 2009.
DOI : 10.1016/j.dsr2.2008.11.031

N. J. Antia and J. Y. Cheng, The keto-carotenoids of two marine coccoid members of the Eustigmatophyceae, British Phycological Journal, vol.263, issue.1, pp.39-50, 1982.
DOI : 10.1080/00071617500650171

Y. Athukorala, K. Kim, and Y. Jeon, Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava, Food and Chemical Toxicology, vol.44, issue.7, pp.1065-1074, 2006.
DOI : 10.1016/j.fct.2006.01.011

R. Bai, M. C. Roach, S. K. Jayaram, J. Barkoczy, G. R. Pettit et al., Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin, Biochemical Pharmacology, vol.45, issue.7, pp.1503-1515, 1993.
DOI : 10.1016/0006-2952(93)90051-W

C. Bailly, Ready for a comeback of natural products in oncology, Biochemical Pharmacology, vol.77, issue.9, pp.1447-1457, 2009.
DOI : 10.1016/j.bcp.2008.12.013

URL : https://hal.archives-ouvertes.fr/hal-00493481

Q. Bao and Y. Shi, Apoptosome: a platform for the activation of initiator caspases, Cell Death and Differentiation, vol.10, issue.1, pp.56-65, 2006.
DOI : 10.1038/sj.cdd.4402028

J. Barrett and S. W. Jeffrey, Chlorophyllase and Formation of an Atypical Chlorophyllide in Marine Algae, PLANT PHYSIOLOGY, vol.39, issue.1, pp.911-917, 1964.
DOI : 10.1104/pp.39.1.44

J. Barrett and S. W. Jeffrey, A note on the occurrence of chlorophyllase in marine algae, Journal of Experimental Marine Biology and Ecology, vol.7, issue.3, pp.255-262, 1971.
DOI : 10.1016/0022-0981(71)90008-6

F. Beppu, Y. Niwano, E. Sato, M. Kohno, T. Tsukui et al., In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH), The Journal of Toxicological Sciences, vol.34, issue.6, pp.693-698, 2009.
DOI : 10.2131/jts.34.693

D. S. Bhakuni and D. S. Rawat, Bioactive Marine Natural Product, 2005.

J. W. Blunt, B. R. Copp, W. P. Hu, M. H. Munro, P. T. Northcote et al., Marine natural products, Natural Product Reports, vol.69, issue.1, pp.35-94, 2008.
DOI : 10.1039/b701534h

K. M. Boatright, M. Renatus, F. L. Scott, S. Sperandio, H. Shin et al., A Unified Model for Apical Caspase Activation, Molecular Cell, vol.11, issue.2, pp.529-541, 2003.
DOI : 10.1016/S1097-2765(03)00051-0

K. M. Bockbrader, M. Tan, and Y. Sun, A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells, Oncogene, vol.10, issue.49, pp.7381-7388, 2005.
DOI : 10.1038/sj.onc.1208888

D. G. Breckenridge and D. Xue, Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases, Current Opinion in Cell Biology, vol.16, issue.6, pp.647-652, 2004.
DOI : 10.1016/j.ceb.2004.09.009

E. Bremer, G. Van-dam, B. J. Kroesen, L. De-leij, and W. Helfrich, Targeted induction of apoptosis for cancer therapy: current progress and prospects, Trends in Molecular Medicine, vol.12, issue.8, pp.382-393, 2006.
DOI : 10.1016/j.molmed.2006.06.002

V. J. Bykov, N. Issaeva, A. Shilov, M. Hultcrantz, E. Pugacheva et al., Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound, Nature Medicine, vol.8, issue.3, pp.282-288, 2002.
DOI : 10.1038/nm0302-282

F. G. Camacho, J. G. Rodríguez, A. S. Mirón, M. C. García, E. H. Belarbi et al., Biotechnological significance of toxic marine dinoflagellates, Biotechnology Advances, vol.25, issue.2, pp.176-194, 2007.
DOI : 10.1016/j.biotechadv.2006.11.008

L. Cavas, Y. Baskin, K. Yurdakoc, and N. Olgun, Antiproliferative and newly attributed apoptotic activities from an invasive marine alga: Caulerpa racemosa var. cylindracea, Journal of Experimental Marine Biology and Ecology, vol.339, issue.1, pp.111-119, 2006.
DOI : 10.1016/j.jembe.2006.07.019

M. Certo, V. D. Moore, M. Nishino, G. Wei, S. Korsmeyer et al., Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members, Cancer Cell, vol.9, issue.5, pp.351-365, 2006.
DOI : 10.1016/j.ccr.2006.03.027

K. H. Cha, S. Y. Koo, and D. Lee, Antiproliferative Effects of Carotenoids Extracted from Chlorella ellipsoidea and Chlorella vulgaris on Human Colon Cancer Cells, Journal of Agricultural and Food Chemistry, vol.56, issue.22, pp.10521-10526, 2008.
DOI : 10.1021/jf802111x

A. H. Daranas, M. Norte, and J. J. Fernández, Toxic marine microalgae, Toxicon, vol.39, issue.8, pp.1101-1132, 2001.
DOI : 10.1016/S0041-0101(00)00255-5

S. K. Das, T. Hashimoto, and K. Kanazawa, Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1780, issue.4, pp.743-749, 2008.
DOI : 10.1016/j.bbagen.2008.01.003

S. K. Das, T. Hashimoto, K. Shimizu, T. Yoshida, T. Sakai et al., Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1726, issue.3, pp.1726-328, 2005.
DOI : 10.1016/j.bbagen.2005.09.007

E. C. De-bruin and J. P. Medema, Apoptosis and non-apoptotic deaths in cancer development and treatment response, Cancer Treatment Reviews, vol.34, issue.8, pp.737-749, 2008.
DOI : 10.1016/j.ctrv.2008.07.001

D. Souza and M. V. , (+)-Discodermolide: A Marine Natural Product Against Cancer, The Scientific World JOURNAL, vol.4, pp.415-436, 2004.
DOI : 10.1100/tsw.2004.96

D. Campo, J. A. Moreno, J. Rodríguez, H. , A. Vargas et al., Carotenoid content of chlorophycean microalgae: factors determining lutein accumulation in Muriellopsis sp. (Chlorophyta), Journal of Biotechnology, vol.76, issue.1, pp.51-59, 2000.
DOI : 10.1016/S0168-1656(99)00178-9

E. Deniaud, J. Fleurence, and M. Lahaye, Preparation and Chemical Characterization of Cell Wall Fractions Enriched in Structural Proteins from Palmaria palmata (Rhodophyta), Botanica Marina, vol.46, issue.4, pp.366-377, 2003.
DOI : 10.1515/BOT.2003.035

M. R. Detty, S. L. Gibson, and S. J. Wagner, Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy, Journal of Medicinal Chemistry, vol.47, issue.16, pp.3897-3915, 2004.
DOI : 10.1021/jm040074b

P. F. Dias, J. M. Siqueira-jr, M. Maraschin, A. G. Ferreira, A. R. Gagliardi et al., A polysaccharide isolated from the brown seaweed Sargassum stenophyllum exerts antivasculogenic effects evidenced by modified morphogenesis, Microvascular Research, vol.75, issue.1, pp.34-44, 2008.
DOI : 10.1016/j.mvr.2007.05.004

M. Dokmanovic and P. A. Marks, Prospects: Histone deacetylase inhibitors, Journal of Cellular Biochemistry, vol.15, issue.2, pp.293-304, 2005.
DOI : 10.1002/jcb.20532

M. Donepudi, A. M. Sweeney, C. Briand, and M. G. Grütter, Insights into the Regulatory Mechanism for Caspase-8 Activation, Molecular Cell, vol.11, issue.2, pp.543-549, 2003.
DOI : 10.1016/S1097-2765(03)00059-5

C. Du, M. Fang, Y. Li, L. Li, and X. Wang, Smac, a Mitochondrial Protein that Promotes Cytochrome c???Dependent Caspase Activation by Eliminating IAP Inhibition, Cell, vol.102, issue.1, pp.33-42, 2000.
DOI : 10.1016/S0092-8674(00)00008-8

L. Dufossé, P. Galaup, A. Yaron, S. M. Arad, P. Blanc et al., Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality?, Trends in Food Science & Technology, vol.16, issue.9, pp.389-406, 2005.
DOI : 10.1016/j.tifs.2005.02.006

W. C. Dunlap, C. N. Battershill, C. H. Liptrot, R. E. Cobb, D. G. Bourne et al., Biomedicinals from the phytosymbionts of marine invertebrates: A molecular approach, Methods, vol.42, issue.4, pp.358-376, 2007.
DOI : 10.1016/j.ymeth.2007.03.001

D. J. Edwards, B. L. Marquez, L. M. Nogle, K. Mcphail, D. E. Goeger et al., Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula, Chemistry & Biology, vol.11, issue.6, pp.817-833, 2004.
DOI : 10.1016/j.chembiol.2004.03.030

R. Esteban, L. Balaguer, E. Manrique, R. Rubio-de-casas, R. Ochoa et al., Alternative methods for sampling and preservation of photosynthetic pigments and tocopherols in plant material from remote locations, Photosynthesis Research, vol.172, issue.1, pp.77-88, 2009.
DOI : 10.1007/s11120-009-9468-5

V. A. Fadok, D. L. Bratton, D. M. Rose, A. Pearson, R. A. Ezekewitz et al., A receptor for phosphatidylserine-specific clearance of apoptotic cells, Nature, vol.405, issue.6782, pp.85-90, 2000.
DOI : 10.1038/35011084

R. H. Feling, G. O. Buchanan, T. J. Mincer, C. A. Kauffman, P. R. Jensen et al., Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora, Angewandte Chemie International Edition, vol.42, issue.3, pp.355-357, 2003.
DOI : 10.1002/anie.200390115

B. Fleischer, H. Schulze-bergkamen, M. Schuchmann, A. Weber, S. Biesterfeld et al., Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma, International Journal of Oncology, vol.28, issue.1, pp.25-32, 2006.
DOI : 10.3892/ijo.28.1.25

F. Folmer, M. Jaspars, M. Dicato, and M. Diederich, Photosynthetic marine organisms as a source of anticancer compounds, Phytochemistry Reviews, vol.116, issue.117, pp.1-23, 2010.
DOI : 10.1007/s11101-010-9200-2

A. Fratianni, L. Cinquanta, and G. Panfili, Degradation of carotenoids in orange juice during microwave heating, LWT - Food Science and Technology, vol.43, issue.6, pp.867-871, 2010.
DOI : 10.1016/j.lwt.2010.01.011

L. Gachard-bouty, L'utilisation de la méthathèse des alcènes pour la synthèse de porphyrines O-et C-glycosylées éthylèniques : application à la photothérapie dynamique, Thèse de Doctorat -Limoges: Faculté des Sciences et Techniques, 2003.

C. Gajate, F. An, and F. Mollinedo, Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743 in Cancer Cells: TRANSCRIPTION-DEPENDENT CELL CYCLE ARREST AND TRANSCRIPTION-INDEPENDENT JNK AND MITOCHONDRIAL MEDIATED APOPTOSIS, Journal of Biological Chemistry, vol.277, issue.44, pp.41580-41589, 2002.
DOI : 10.1074/jbc.M204644200

L. F. García-fernández, A. Losada, V. Alcaide, A. M. Álvarez, A. Cuadrado et al., Aplidin??? induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C ??, Oncogene, vol.21, issue.49, pp.7533-7544, 2002.
DOI : 10.1038/sj.onc.1205972

M. Hosokawa, M. Kudo, H. Maeda, H. Kohno, T. Tanaka et al., Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPAR?? ligand, troglitazone, on colon cancer cells, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1675, issue.1-3, pp.113-119, 2004.
DOI : 10.1016/j.bbagen.2004.08.012

M. Hosokawa, S. Wanezaki, K. Miyauchi, H. Kurihara, H. Kohno et al., Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60., Food Science and Technology Research, vol.5, issue.3, pp.243-246, 1999.
DOI : 10.3136/fstr.5.243

D. T. Hung, J. Chen, and S. L. Schreiber, (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest, Chemistry & Biology, vol.3, issue.4, pp.287-293, 1996.
DOI : 10.1016/S1074-5521(96)90108-8

M. L. Hyer, T. Samuel, and J. C. Reed, The FLIP-Side of Fas Signaling, Clinical Cancer Research, vol.12, issue.20, pp.5929-5931, 2006.
DOI : 10.1158/1078-0432.CCR-06-2098

N. Isakov, D. Galron, T. Mustelin, G. R. Pettit, and A. Altman, Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C, Journal of Immunology, vol.150, issue.4, pp.1195-1204, 1993.

K. L. Jackson, J. A. Henderson, and A. J. Phillips, The Halichondrins and E7389, Chemical Reviews, vol.109, issue.7, pp.3044-3079, 2009.
DOI : 10.1021/cr900016w

M. Jaren-galan, U. Nienaber, and S. J. Schwartz, ) Oleoresin Extraction with Supercritical Carbon Dioxide, Journal of Agricultural and Food Chemistry, vol.47, issue.9, pp.3558-3564, 1999.
DOI : 10.1021/jf9900985

S. W. Jeffrey, An improved thin-layer chromatographic technique for marine phytoplankton pigments, Limnology and Oceanography, vol.26, issue.1, pp.191-197, 1981.
DOI : 10.4319/lo.1981.26.1.0191

S. W. Jeffrey and G. M. Hallegraeff, Chlorophyllase distribution in ten classes of phytoplankton: a problem for chlorophyll analysis, Marine Ecology Progress Series, vol.35, pp.293-304, 1987.
DOI : 10.3354/meps035293

M. A. Jordan, K. Kamath, T. Manna, T. Okouneva, H. P. Miller et al., The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth, Molecular Cancer Therapeutics, vol.4, issue.7, pp.1086-1095, 2005.
DOI : 10.1158/1535-7163.MCT-04-0345

S. U. Kadam and P. Prabhasankar, Marine foods as functional ingredients in bakery and pasta products, Food Research International, vol.43, issue.8, pp.1975-1980, 2010.
DOI : 10.1016/j.foodres.2010.06.007

B. Kaeffer, C. Bénard, M. Lahaye, H. M. Blottière, and C. Cherbut, Biological Properties of Ulvan, a New Source of Green Seaweed Sulfated Polysaccharides, on Cultured Normal and Cancerous Colonic Epithelial Cells, Planta Medica, vol.65, issue.6, pp.527-531, 1999.
DOI : 10.1055/s-1999-14009

G. P. Kalemkerian, X. Ou, M. R. Adil, R. Rosati, M. M. Khoulani et al., Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: induction of apoptosis and bcl-2 modification, Cancer Chemotherapy and Pharmacology, vol.43, issue.6, pp.507-515, 1999.
DOI : 10.1007/s002800050931

K. Kanoh, S. Kohno, T. Asari, T. Harada, J. Katada et al., (???)-Phenylahistin: A new mammalian cell cycle inhibitor produced by aspergillus ustus, Bioorganic & Medicinal Chemistry Letters, vol.7, issue.22, pp.2847-2852, 1997.
DOI : 10.1016/S0960-894X(97)10104-4

S. Karboune, R. Neufeld, and S. Kermasha, Immobilization and biocatalysis of chlorophyllase in selected organic solvent systems, Journal of Biotechnology, vol.120, issue.3, pp.273-283, 2005.
DOI : 10.1016/j.jbiotec.2005.06.025

. Karp, Biologie cellulaire et moléculaire, 2010.

J. Kerr, Apoptosis : a basic biological phenomenon with wide-ranging implactions in tissue kinetics, 1972.

D. H. Kim, J. H. Kim, S. E. Bae, J. H. Seo, T. K. Oh et al., Species Xylanase, Journal of Agricultural and Food Chemistry, vol.53, issue.7, pp.2541-2545, 2005.
DOI : 10.1021/jf048097m

K. Kim, S. Heo, S. Kang, G. Ahn, and Y. Jeon, Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway, Toxicology in Vitro, vol.24, issue.6, pp.1648-1654, 2010.
DOI : 10.1016/j.tiv.2010.05.023

M. Kladi, H. Xenaki, C. Vagias, P. Papazafiri, and V. Roussis, New cytotoxic sesquiterpenes from the red algae Laurencia obtusa and Laurencia microcladia, Tetrahedron, vol.62, issue.1, pp.182-189, 2006.
DOI : 10.1016/j.tet.2005.09.113

B. Klejdus, J. Kopecký, L. Benesová, and J. Vacek, Solid-phase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species, Journal of Chromatography A, vol.1216, issue.5, pp.763-771, 2009.
DOI : 10.1016/j.chroma.2008.11.096

J. Kobayashi and M. Ishibashi, Amphidinolides: Unique Macrolides from Marine Dinoflagellates, HETEROCYCLES, vol.44, issue.1, pp.543-572, 1997.
DOI : 10.3987/REV-96-SR1

J. Kobayashi, N. Yamaguchi, and M. Ishibashi, Amphidinin A, a novel amphidinolide-related metabolite from the cultured marine dinoflagellate Amphidinium sp., Tetrahedron Letters, vol.35, issue.38, pp.7049-7050, 1994.
DOI : 10.1016/0040-4039(94)88222-3

M. Kobayashi, T. Natsume, S. Tamaoki, J. I. Watanabe, H. Asano et al., Antitumor Activity of TZT-1027, a Novel Doiastatin 10 Derivative, Japanese Journal of Cancer Research, vol.51, issue.Suppl. 4, pp.316-327, 1997.
DOI : 10.1111/j.1349-7006.1997.tb00383.x

J. Kornprobst, Substances naturelles d'origine marine -Chimiodiversité - Pharmacodiversité -Biotechnologies, 2005.

J. Kortmansky and G. K. Schwartz, Bryostatin-1: A Novel PKC Inhibitor in Clinical Development, Cancer Investigation, vol.53, issue.6, pp.924-936, 2003.
DOI : 10.1016/0167-4889(96)00018-3

E. Kotake-nara, A. Asai, and A. Nagao, Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells, Cancer Letters, vol.220, issue.1, pp.75-84, 2005.
DOI : 10.1016/j.canlet.2004.07.048

S. Kotamraju, S. V. Kalivendi, E. Konorev, C. R. Chitambar, J. Joseph et al., Oxidant-Induced Iron Signaling in Doxorubicin-Mediated Apoptosis, In Methods in Enzymology, vol.378, pp.362-382, 2004.
DOI : 10.1016/S0076-6879(04)78026-X

T. Kuwana, L. Bouchier-hayes, J. E. Chipuk, C. Bonzon, B. A. Sullivan et al., BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly, Molecular Cell, vol.17, issue.4, pp.525-535, 2005.
DOI : 10.1016/j.molcel.2005.02.003

T. Kuwana, M. R. Mackey, G. Perkins, M. H. Ellisman, M. Latterich et al., Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane, pp.331-342, 2002.
DOI : 10.1016/S0092-8674(02)01036-X

G. Kuznetsov, K. Tendyke, M. Towle, H. Cheng, J. Liu et al., Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin, Molecular Cancer Therapeutics, vol.8, issue.10, pp.2852-2860, 2009.
DOI : 10.1158/1535-7163.MCT-09-0301

H. Kwon, S. Bae, K. Kim, C. Han, S. Cho et al., Induction of apoptosis in HeLa cells by ethanolic extract of Corallina pilulifera, Food Chemistry, vol.104, issue.1, pp.196-201, 2007.
DOI : 10.1016/j.foodchem.2006.11.031

M. Kwon and T. Nam, A polysaccharide of the marine alga Capsosiphon fulvescens induces apoptosis in AGS gastric cancer cells via an IGF-IR-mediated PI3K/Akt pathway, Cell Biology International, vol.31, issue.8, pp.31-768, 2007.
DOI : 10.1016/j.cellbi.2007.01.010

J. F. Leal, V. García-hernández, V. Moneo, A. Domingo, J. A. Bueren-calabuig et al., Molecular pharmacology and antitumor activity of Zalypsis?? in several human cancer cell lines, Biochemical Pharmacology, vol.78, issue.2, pp.162-170, 2009.
DOI : 10.1016/j.bcp.2009.04.003

P. Lechat, Pharmacologie -DCEM1, Faculté de médecine Pierre et Marie Curie, 2006.

H. S. Lee and G. A. Coates, Effect of thermal pasteurization on Valencia orange juice color and pigments. Lebensmittel-Wissenschaft und-Technologie, pp.153-156, 2003.

J. Lee, C. Yoo, S. Jun, C. Ahn, and H. Oh, Comparison of several methods for effective lipid extraction from microalgae, Bioresource Technology, vol.101, issue.1, pp.75-77, 2010.
DOI : 10.1016/j.biortech.2009.03.058

R. D. Leek, I. Stratford, and A. L. Harris, The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway, Cancer Research, vol.65, issue.10, pp.4147-4152, 2005.
DOI : 10.1158/0008-5472.CAN-04-2184

A. Letai, M. C. Bassik, L. D. Walensky, M. D. Sorcinelli, S. Weiler et al., Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics, Cancer Cell, vol.2, issue.3, pp.183-192, 2002.
DOI : 10.1016/S1535-6108(02)00127-7

D. Li, J. I. Williams, and R. J. Pietras, Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression, Oncogene, vol.21, issue.18, pp.2805-2814, 2002.
DOI : 10.1038/sj.onc.1205410

H. Li, K. Cheng, C. Wong, K. Fan, F. Chen et al., Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae, Food Chemistry, vol.102, issue.3, pp.771-776, 2007.
DOI : 10.1016/j.foodchem.2006.06.022

H. Li, H. Zhu, C. Xu, and J. Yuan, Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis, Cell, vol.94, issue.4, pp.491-501, 1998.
DOI : 10.1016/S0092-8674(00)81590-1

Y. H. Ling, M. Aracil, J. Jimeno, R. Perez-soler, and Y. Zou, Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models, European Journal of Cancer, vol.45, issue.10, pp.1855-1864, 2009.
DOI : 10.1016/j.ejca.2009.03.003

F. Liu and G. A. Rabinovich, Galectins as modulators of tumour progression, Nature Reviews Cancer, vol.19, issue.1, pp.29-41, 2005.
DOI : 10.1038/nrc1275

R. E. Longley, S. P. Gunasekera, D. Faherty, J. Mclane, and F. Dumont, Immunosuppression by Discodermolide, Annals of the New York Academy of Sciences, vol.2, issue.9, pp.94-107, 1993.
DOI : 10.1111/j.1749-6632.1993.tb17145.x

R. T. Lorenz and G. R. Cysewski, Commercial potential for Haematococcus microalgae as a natural source of astaxanthin, Trends in Biotechnology, vol.18, issue.4, pp.160-167, 2000.
DOI : 10.1016/S0167-7799(00)01433-5

M. D. Macías-sánchez, C. Mantell, M. Rodríguez, E. Martínez-de-la-ossa, L. M. Lubián et al., Supercritical fluid extraction of carotenoids and chlorophyll a from Nannochloropsis gaditana, Journal of Food Engineering, vol.66, issue.2, pp.245-251, 2005.
DOI : 10.1016/j.jfoodeng.2004.03.021

M. D. Macías-sánchez, C. Mantell, M. Rodríguez, E. Martínez-de-la-ossa, L. M. Lubián et al., Supercritical fluid extraction of carotenoids and chlorophyll a from Synechococcus sp., The Journal of Supercritical Fluids, vol.39, issue.3, pp.323-329, 2007.
DOI : 10.1016/j.supflu.2006.03.008

M. D. Macías-sánchez, C. Mantell, M. Rodríguez, E. Martínez-de-la-ossa, L. M. Lubián et al., Comparison of supercritical fluid and ultrasound-assisted extraction of carotenoids and chlorophyll a from Dunaliella salina, Talanta, vol.77, issue.3, pp.948-952, 2009.
DOI : 10.1016/j.talanta.2008.07.032

M. D. Macías-sánchez, C. M. Serrano, M. R. Rodríguez, and E. Martínez-de-la-ossa, Kinetics of the supercritical fluid extraction of carotenoids from microalgae with CO2 and ethanol as cosolvent, Chemical Engineering Journal, vol.150, issue.1, pp.104-113, 2009.
DOI : 10.1016/j.cej.2008.12.006

L. Mallucci, V. Wells, A. Danikas, and D. Davies, Turning cell cycle controller genes into cancer drugs, Biochemical Pharmacology, vol.66, issue.8, pp.1563-1569, 2003.
DOI : 10.1016/S0006-2952(03)00512-4

A. Mani and E. P. Gelmann, The Ubiquitin-Proteasome Pathway and Its Role in Cancer, Journal of Clinical Oncology, vol.23, issue.21, pp.4776-4789, 2005.
DOI : 10.1200/JCO.2005.05.081

A. C. Manzan, F. S. Toniolo, E. Bredow, and N. P. Povh, [L.] by Steam Distillation and Extraction with Volatile Solvents, Journal of Agricultural and Food Chemistry, vol.51, issue.23, pp.6802-6807, 2003.
DOI : 10.1021/jf030161x

L. A. Martello, H. M. Mcdaid, D. L. Regl, C. H. Yang, D. Meng et al., Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines, Clinical Cancer Research, vol.6, issue.5, pp.1978-1987, 2000.

T. M. Mata, A. A. Martins, and N. S. Caetano, Microalgae for biodiesel production and other applications: A review, Renewable and Sustainable Energy Reviews, vol.14, issue.1, pp.217-232, 2010.
DOI : 10.1016/j.rser.2009.07.020

A. M. Mayer, K. B. Glaser, C. Cuevas, R. S. Jacobs, W. Kem et al., The odyssey of marine pharmaceuticals: a current pipeline perspective, Trends in Pharmacological Sciences, vol.31, issue.6, pp.255-265, 2010.
DOI : 10.1016/j.tips.2010.02.005

A. M. Mayer and K. R. Gustafson, Marine pharmacology in 2003???2004: Anti-tumour and cytotoxic compounds, European Journal of Cancer, vol.42, issue.14, pp.2241-2270, 2003.
DOI : 10.1016/j.ejca.2006.05.019

R. L. Mendes, B. P. Nobre, M. T. Cardoso, A. P. Pereira, and A. F. Palavra, Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae, Inorganica Chimica Acta, vol.356, pp.328-334, 2003.
DOI : 10.1016/S0020-1693(03)00363-3

J. A. Mendiola, L. Jaime, S. Santoyo, G. Reglero, A. Cifuentes et al., Screening of functional compounds in supercritical fluid extracts from Spirulina platensis, Food Chemistry, vol.102, issue.4, pp.1357-1367, 2007.
DOI : 10.1016/j.foodchem.2006.06.068

O. Micheau, M. Thome, P. Schneider, N. Holler, J. R. Tschopp et al., The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex, Journal of Biological Chemistry, vol.277, issue.47, pp.45162-45171, 2002.
DOI : 10.1074/jbc.M206882200

J. Milledge, Commercial application of microalgae other than as biofuels: a brief review, Reviews in Environmental Science and Bio/Technology, vol.26, issue.1, pp.1-11, 2010.
DOI : 10.1007/s11157-010-9214-7

S. Minucci and P. G. Pelicci, Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer, Nature Reviews Cancer, vol.105, issue.1, pp.38-51, 2006.
DOI : 10.1038/nrc1779

K. S. Moore, S. Wehrli, H. Roder, M. Rogers, J. N. Forrest et al., Squalamine: an aminosterol antibiotic from the shark., Proceedings of the National Academy of Sciences, vol.90, issue.4, pp.1354-1358, 1993.
DOI : 10.1073/pnas.90.4.1354

D. Moreau, H. Thomas-guyon, C. Jacquot, M. Jugé, G. Culioli et al., An extract from the brown alga Bifurcaria bifurcata induces irreversible arrest of cell proliferation in a non-small-cell bronchopulmonary carcinoma line, Journal of Applied Phycology, vol.2, issue.1, pp.87-93, 2006.
DOI : 10.1007/s10811-005-9019-1

D. Moreau, C. Tomasoni, C. Jacquot, R. Kaas, L. Guedes et al., Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines, Environmental Toxicology and Pharmacology, vol.22, issue.1, pp.97-103, 2006.
DOI : 10.1016/j.etap.2006.01.004

T. Mosmann, Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays, Journal of Immunological Methods, vol.65, issue.1-2, pp.55-63, 1983.
DOI : 10.1016/0022-1759(83)90303-4

S. Nagata, Apoptosis by Death Factor, Cell, vol.88, issue.3, pp.355-365, 1997.
DOI : 10.1016/S0092-8674(00)81874-7

Y. Nakazawa, T. Sashima, M. Hosokawa, and K. Miyashita, Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines, Journal of Functional Foods, vol.1, issue.1, pp.88-97, 2009.
DOI : 10.1016/j.jff.2008.09.015

T. Natori, M. Morita, K. Akimoto, and Y. Koezuka, Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus, Tetrahedron, vol.50, issue.9, pp.2771-2784, 1994.
DOI : 10.1016/S0040-4020(01)86991-X

D. J. Newman, G. M. Cragg, and C. N. Battershill, Therapeutic agents from the sea: Biodiversity, chemo-evolutionary insight and advances to the end of Darwin's 200th year. Diving and Hyperbaric Medicine, pp.216-225, 2009.

B. Nicholson, G. K. Lloyd, B. R. Miller, M. A. Palladino, Y. Kiso et al., NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent, Anti-Cancer Drugs, vol.17, issue.1, pp.25-31, 2006.
DOI : 10.1097/01.cad.0000182745.01612.8a

H. Nishino, M. Murakoshi, H. Tokuda, and Y. Satomi, Cancer prevention by carotenoids, Archives of Biochemistry and Biophysics, vol.483, issue.2, pp.165-168, 2009.
DOI : 10.1016/j.abb.2008.09.011

H. Nishino, H. Tokuda, M. Murakoshi, Y. Satomi, M. Masuda et al., Cancer prevention by natural carotenoids, BioFactors, vol.1314, pp.89-94, 2000.

S. Nobili, D. Lippi, E. Witort, M. Donnini, L. Bausi et al., Natural compounds for cancer treatment and prevention, Pharmacological Research, vol.59, issue.6, pp.365-378, 2009.
DOI : 10.1016/j.phrs.2009.01.017

T. Okouneva, O. Azarenko, L. Wilson, B. A. Littlefield, and M. A. Jordan, Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase, Molecular Cancer Therapeutics, vol.7, issue.7, pp.2003-2011, 2008.
DOI : 10.1158/1535-7163.MCT-08-0095

M. Olaizola, Commercial development of microalgal biotechnology: from the test tube to the marketplace, Biomolecular Engineering, vol.20, issue.4-6, pp.4-6, 2003.
DOI : 10.1016/S1389-0344(03)00076-5

B. M. Olivera, ) ?-Conotoxin MVIIA: from previous termmarinenext term snail venom to analgesic drug, 2000.

T. Oltersdorf, S. W. Elmore, A. R. Shoemaker, R. C. Armstrong, D. J. Augeri et al., An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, vol.20, issue.7042, pp.677-681, 2005.
DOI : 10.1016/0014-5793(95)00062-E

P. Ozenda, Les végétaux organisation et diversité biologique, 2000.

J. A. Palermo, P. B. Flower, and A. M. Seldes, Chondriamides A and B, new indolic metabolites from the red alga Chondria sp., Tetrahedron Letters, vol.33, issue.22, pp.3097-3100, 1992.
DOI : 10.1016/S0040-4039(00)79823-6

P. Palozza, G. Calviello, S. Serini, N. Maggiano, P. Lanza et al., ??-carotene at high concentrations induces apoptosis by enhancing oxy-radical production in human adenocarcinoma cells, Free Radical Biology and Medicine, vol.30, issue.9, pp.1000-1007, 2001.
DOI : 10.1016/S0891-5849(01)00488-9

T. R. Parsons, Y. Maita, and C. M. Lalli, A manual of chemical and biological methods for seawater analysis, 1984.

M. K. Pec, A. Aguirre, K. Moser-thier, J. J. Fernández, M. L. Souto et al., Induction of apoptosis in estrogen dependent and independent breast cancer cells by the marine terpenoid dehydrothyrsiferol, Biochemical Pharmacology, vol.65, issue.9, pp.1451-1461, 2003.
DOI : 10.1016/S0006-2952(03)00123-0

O. Perez-garcia, F. M. Escalante, L. E. De-bashan, and Y. Bashan, Heterotrophic cultures of microalgae: Metabolism and potential products, Water Research, vol.45, issue.1, 2010.
DOI : 10.1016/j.watres.2010.08.037

G. R. Pettit, Y. Fujii, J. A. Hasler, and J. M. Schmidt, Isolation and Characterization of Palystatins A-D, Journal of Natural Products, vol.45, issue.3, pp.272-276, 1982.
DOI : 10.1021/np50021a007

G. R. Pettit, Y. Kamano, Y. Fujii, C. L. Herald, M. Inoue et al., Marine Animal Biosynthetic Constituents For Cancer Chemotherapy, Journal of Natural Products, vol.44, issue.4, pp.482-485, 1981.
DOI : 10.1021/np50016a016

C. Pop, J. Timmer, S. Sperandio, and G. S. Salvesen, The Apoptosome Activates Caspase-9 by Dimerization, Molecular Cell, vol.22, issue.2, pp.269-275, 2006.
DOI : 10.1016/j.molcel.2006.03.009

R. Ravatn, V. Wells, L. Nelson, D. Vettori, L. Mallucci et al., Circumventing Multidrug Resistance in Cancer by ??-Galactoside Binding Protein, an Antiproliferative Cytokine, Cancer Research, vol.65, issue.5, pp.1631-1634, 2005.
DOI : 10.1158/0008-5472.CAN-04-1970

A. Rodríguez-bernaldo-de-quirós and H. S. Costa, Analysis of carotenoids in vegetable and plasma samples: A review, Journal of Food Composition and Analysis, vol.19, issue.2-3, pp.97-111, 2006.
DOI : 10.1016/j.jfca.2005.04.004

M. A. Rostagno, M. Palma, and C. G. Barroso, Ultrasound-assisted extraction of isoflavones from soy beverages blended with fruit juices, Analytica Chimica Acta, vol.597, issue.2, pp.265-272, 2007.
DOI : 10.1016/j.aca.2007.07.006

N. Roy, The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy, Cell, vol.80, issue.1, pp.167-178, 1995.
DOI : 10.1016/0092-8674(95)90461-1

G. Ruiz, Extraction, Détermination structurale et Valorisation Chimique de Phycocolloïdes d'Algue Rouges, Thèse de Doctorat -Limoges: Faculté des Sciences et Techniques, 2005.

N. M. Sachindra, N. Bhaskar, and N. S. Mahendrakar, Carotenoids in crabs from marine and fresh waters of India, LWT - Food Science and Technology, vol.38, issue.3, pp.221-225, 2005.
DOI : 10.1016/j.lwt.2004.06.003

K. Saito, M. Nishijima, N. Ohno, T. Yadomae, and T. Miyazaki, Structure and Antitumor Activity of the Less-Branched Derivatives of an Alkali-Soluble Glucan Isolated from Omphalia lapidescens. Studies on Fungal Polysaccharide. XXXVIII., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.40, issue.1, pp.261-263, 1992.
DOI : 10.1248/cpb.40.261

A. M. Sánchez, S. Malagarie-cazenave, N. Olea, D. Vara, C. Cuevas et al., Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKC-? activation, European Journal of Pharmacology, vol.58423, pp.237-245, 2008.

K. V. Sashidhara, K. N. White, and P. Crews, A Selective Account of Effective Paradigms and Significant Outcomes in the Discovery of, Inspirational Marine Natural Products Journal of Natural Products, vol.72, issue.3, pp.588-603, 2009.

Y. Satomi and H. Nishino, Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1790, issue.4, pp.260-266, 2009.
DOI : 10.1016/j.bbagen.2009.01.003

A. D. Schimmer, Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice, Cancer Research, vol.64, issue.20, pp.7183-7190, 2004.
DOI : 10.1158/0008-5472.CAN-04-1918

J. D. Scott and R. M. Williams, Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics, Chemical Reviews, vol.102, issue.5, pp.1669-1730, 2002.
DOI : 10.1021/cr010212u

D. A. Sharp, D. A. Lawrence, and A. Ashkenazi, Selective Knockdown of the Long Variant of Cellular FLICE Inhibitory Protein Augments Death Receptor-mediated Caspase-8 Activation and Apoptosis, Journal of Biological Chemistry, vol.280, issue.19, pp.19401-19409, 2005.
DOI : 10.1074/jbc.M413962200

Y. Shimizu, Microalgal metabolites, Current Opinion in Microbiology, vol.6, issue.3, pp.236-243, 2003.
DOI : 10.1016/S1369-5274(03)00064-X

E. L. Sievers, Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg), Blood Cells, Molecules, and Diseases, vol.31, issue.1, pp.7-10, 2003.
DOI : 10.1016/S1079-9796(03)00117-7

T. L. Simmons, E. Andrianasolo, K. Mcphail, P. Flatt, and W. H. Gerwick, Marine natural products as anticancer drugs, Molecular Cancer Therapeutics, vol.4, issue.2, pp.333-342, 2005.

A. J. Smit, Medicinal and pharmaceutical uses of seaweed natural products: A review, Journal of Applied Phycology, vol.16, issue.4, pp.245-262, 2004.
DOI : 10.1023/B:JAPH.0000047783.36600.ef

H. D. Soule, J. Vazquez, and A. Long, A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2, JNCI: Journal of the National Cancer Institute, vol.51, issue.5, pp.1409-1416, 1973.
DOI : 10.1093/jnci/51.5.1409

H. R. Stennicke, Q. L. Deveraux, E. W. Humke, J. C. Reed, V. M. Dixit et al., Caspase-9 Can Be Activated without Proteolytic Processing, Caspase-9 Can Be Activated without Proteolytic Processing, pp.8359-8362, 1999.
DOI : 10.1074/jbc.274.13.8359

J. D. Strickland and T. R. Parsons, A practical handbook of seawater analysis, Bull. Fish. Res. Bd. Can, 1972.

Y. Sun, G. Ma, X. Ye, Y. Kakuda, and R. Meng, Stability of all-trans-??-carotene under ultrasound treatment in a model system: Effects of different factors, kinetics and newly formed compounds, Ultrasonics Sonochemistry, vol.17, issue.4, pp.654-661, 2009.
DOI : 10.1016/j.ultsonch.2009.12.005

S. Protease and H. , Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death, Molecular Cell, vol.8, issue.3, pp.613-621

Y. Takebayashi, P. Pourquier, D. B. Zimonjic, K. Nakayama, S. Emmert et al., Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair, Nature Medicine, vol.7, issue.8, pp.961-966, 2001.
DOI : 10.1038/91008

R. Talpir, Y. Benayahu, Y. Kashman, L. Pannell, and M. Schleyer, Hemiasterlin and geodiamolide TA; two new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick), Tetrahedron Letters, vol.35, issue.25, pp.4453-4456, 1994.
DOI : 10.1016/S0040-4039(00)73382-X

L. T. Tan, Bioactive natural products from marine cyanobacteria for drug discovery, Phytochemistry, vol.68, issue.7, pp.954-979, 2007.
DOI : 10.1016/j.phytochem.2007.01.012

M. Tsuda, T. Endo, and J. Kobayashi, sp., The Journal of Organic Chemistry, vol.65, issue.5, pp.1349-1352, 2000.
DOI : 10.1021/jo991393r

A. M. Verhagen, P. G. Ekert, M. Pakusch, J. Silke, L. M. Connolly et al., Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins, Cell, vol.102, issue.1, pp.43-53, 2000.
DOI : 10.1016/S0092-8674(00)00009-X

B. Vogelstein, D. Lane, and A. J. Levine, Surfing the p53 network, Nature, vol.408, issue.6810, pp.307-310, 2000.
DOI : 10.1038/35042675

K. Von-schwarzenberg and A. M. Vollmar, Marine compounds as lead structures and chemical tools for cancer therapy. Cancer Letters doi:10, 2010.

N. R. Wall, R. M. Mohammad, and A. M. Katib, Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh, Leukemia Research, vol.23, issue.10, pp.881-888, 1999.
DOI : 10.1016/S0145-2126(99)00108-3

H. Wang, J. Pan, C. Chen, C. Chiu, M. Yang et al., Identification of anti-lung cancer extract from Chlorella vulgaris C-C by antioxidant property using supercritical carbon dioxide extraction, Process Biochemistry, vol.45, issue.12, 2010.
DOI : 10.1016/j.procbio.2010.05.023

J. Wang, X. Xiao, and G. Li, Study of vacuum microwave-assisted extraction of polyphenolic compounds and pigment from Chinese herbs, Journal of Chromatography A, vol.1198, issue.1199, pp.1198-1199, 2008.
DOI : 10.1016/j.chroma.2008.05.045

L. Wang and C. L. Weller, Recent advances in extraction of nutraceuticals from plants, Trends in Food Science & Technology, vol.17, issue.6, pp.300-312, 2006.
DOI : 10.1016/j.tifs.2005.12.004

M. C. Wei, W. Zong, E. H. Cheng, T. Lindsten, V. Panoutsakopoulou et al., Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death, Science, vol.292, issue.5517, pp.727-730, 2001.
DOI : 10.1126/science.1059108

P. A. Wender, C. M. Cribbs, K. F. Koehler, N. A. Sharkey, C. L. Herald et al., Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C., Proceedings of the National Academy of Sciences, vol.85, issue.19, pp.7197-7201, 1988.
DOI : 10.1073/pnas.85.19.7197

A. E. Wright, D. A. Forleo, G. P. Gunawardana, S. P. Gunasekera, F. E. Koehn et al., Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata, The Journal of Organic Chemistry, vol.55, issue.15, pp.4508-4512, 1990.
DOI : 10.1021/jo00302a006

X. Xiao, J. Wang, G. Wang, J. Wang, and G. Li, Evaluation of vacuum microwave-assisted extraction technique for the extraction of antioxidants from plant samples, Journal of Chromatography A, vol.1216, issue.51, pp.1216-8867, 2009.
DOI : 10.1016/j.chroma.2009.10.087

Y. Yamazaki, K. Kohno, H. Yasui, Y. Kiso, M. Akamatsu et al., Tubulin Photoaffinity Labeling with Biotin-Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents, ChemBioChem, vol.6, issue.18, pp.3074-3081, 2008.
DOI : 10.1002/cbic.200800317

G. Yang, J. Schmieg, M. Tsuji, and R. W. Franck, The C-Glycoside Analogue of the Immunostimulant??-Galactosylceramide (KRN7000): Synthesis and Striking Enhancement of Activity, Angewandte Chemie International Edition, vol.43, issue.29, pp.3818-3822, 2004.
DOI : 10.1002/anie.200454215

H. Yang, K. Hoshino, B. Sanchez-gonzalez, H. Kantarjian, and G. Garcia-manero, Antileukemia activity of the combination of 5-aza-2???-deoxycytidine with valproic acid, Leukemia Research, vol.29, issue.7, pp.739-748, 2005.
DOI : 10.1016/j.leukres.2004.11.022

J. Yokota, Tumor progression and metastasis, Carcinogenesis, vol.21, issue.3, pp.497-503, 2000.
DOI : 10.1093/carcin/21.3.497

B. You and V. Trillet-lenoir, Th??rapeutiques anticanc??reuses cibl??es, La Revue de M??decine Interne, vol.27, pp.285-288, 2006.
DOI : 10.1016/j.revmed.2006.09.012

Y. V. Yuan and N. A. Walsh, Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds, Food and Chemical Toxicology, vol.44, issue.7, pp.1144-1150, 2006.
DOI : 10.1016/j.fct.2006.02.002

M. Zewail-foote and L. H. Hurley, Differential Rates of Reversibility of Ecteinascidin 743???DNA Covalent Adducts from Different Sequences Lead to Migration to Favored Bonding Sites, Journal of the American Chemical Society, vol.123, issue.27, pp.6485-6495, 2001.
DOI : 10.1021/ja004023p

M. Zubia, M. S. Fabre, V. Kerjean, K. L. Lann, V. Stiger-pouvreau et al., Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts, Food Chemistry, vol.116, issue.3, pp.693-701, 2009.
DOI : 10.1016/j.foodchem.2009.03.025