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Caractérisation de la réponse cérébrale à la douleur et ses modulations

Florence Pomares Borgetto 1 
1 Neuropain
Intégration centrale de la douleur chez l'homme
Abstract : Pain is a complex and multidimensional experience that can be modulated by many factors. In order to better understand the respective role and function of the brain regions involved in the processing and the modulation of pain perception, the first part of this thesis focuses on the evaluation with functional magnetic resonance imaging (fMRI) of changes in the brain response to pain through two modulations of pain perception. The first study examines the effect of a negative emotional context on pain perception in order to dissociate the brain areas responding to pain from that related to the emotional context. The second study focuses on the effect of the manipulation of perceived duration of a painful stimulation on the perception of pain. The use of this illusion allows us to change the perceived intensity of pain and to assess the brain areas involved in this type of modulation at given intensity of thermal stimulation. We succeeded to increase or decrease perceived pain intensity and we observed that emotion involves pregenual part of the anterior cingulate cortex, while the illusion of a shortened duration involves an occipito-parietal attentional network. The second part of this thesis focuses on characterizing the time course of the hemodynamic response recorded with fMRI in two important areas processing pain that are the insula and the cingulate cortex. Painful sensation is characterized by a shortened latency of hemodynamic response compared to a non-painful sensation in the anterior insula and the midcingulate cortex, while it is possible to differentiate painful and non-painful sensation by the amplitude of the hemodynamic response in the posterior insula.
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Submitted on : Friday, February 17, 2012 - 2:11:43 PM
Last modification on : Friday, April 15, 2022 - 1:45:59 PM
Long-term archiving on: : Friday, May 18, 2012 - 2:30:09 AM


  • HAL Id : tel-00671420, version 1


Florence Pomares Borgetto. Caractérisation de la réponse cérébrale à la douleur et ses modulations. Neurosciences. Université Claude Bernard - Lyon I, 2011. Français. ⟨NNT : ⟩. ⟨tel-00671420⟩



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