D. Mhz, CH 2 sucre ), CH arom, p.277395057

1. Hz and . Hz, 1H), Hz Hz 1H 1H 1H, vol.687, issue.8, pp.650685031573-1

D. Mhz, CH 2 sucre+benzyle ) ; 76,4 ; 77,5, CH sucre, vol.721, issue.142, pp.684-1286

1. Hz and J. =. , 87 (s, 2H) (d, J = 9,0 Hz, 1H, H 1' ), Hz 1H 1H 1H 1H Hz, vol.415222841, issue.7d 2, pp.55648382637309-716

D. Mhz, CH 2 sucre+benzyle ), CH sucre, vol.7213, issue.138, pp.685-1284

D. Mhz, CH 2 sucre+benzyle ), CH sucre, vol.748, issue.141, pp.68-75

. Mhz, CH 2 sucre+benzyle ), CH sucre, vol.73, issue.180, pp.684-12881

. Hz, 57 (d, J = 12,5 Hz, 1H), Hz 1H 1H Hz 1H Hz 1H Hz 1H 1H 1H, vol.4165, issue.7, pp.210-44350647084936296

. Mhz, CH 2 sucre+benzyle ), CH sucre, vol.76, issue.181, pp.67-76

1. Hz, 92 (s, 2H), Hz, 1H), pp.62-4857684, 2001.

D. Mhz, CH 2 sucre+benzyle ), CH sucre, vol.74, issue.168, pp.68-72

1. Hz, 93 (s, 2H), pp.7885-691

D. Mhz, CH 2 sucre+benzyle ), CH sucreC arom, vol.72, issue.168, pp.683-12857

1. Hz and 1. Hz, 44 (se, 1H, H 1' ), pp.4036-5920428, 2007.

1. Hz, 40 (se, 1H, H 1' ), 1H, vol.5, issue.6, p.4092

1. Hz, d, J = 9,5 Hz, 1H, H 1', 1H Hz 1H, vol.5, issue.8, pp.4667899509-1

. Mhz, CH 3 acétate, pp.2044-2046

F. =-142°ct and J. =. , t, J = 9,5 Hz, 1H, Hz, 1H Hz 1H 1H, vol.435, issue.7, pp.30-4295563235437, 2000.

1. Hz, 57 (d, J = 3,5 Hz, 1H), Hz 1H Hz, vol.7, issue.7 2, pp.6979-6980

D. Mhz, CH 2 sucre ), CH sucreC arom, vol.8, issue.170, pp.194-169

. Mhz, CH 3 acétate )CH 2 sucre ), CH sucre, vol.20, issue.148, pp.7-7

. Masse-exacte, ES) : calculée pour C 22 H 23 NNaO 11, 1163.

. Mhz, CH 3 acétate )CH 2 sucre ), CH sucre, vol.20, issue.152, pp.4-5

. Mhz, CH 3 acétate )CH 2 sucre ), CH sucreC=O isatine, vol.20, issue.170, p.754

J. =. Hzt, dt, J 1 = 8,0 Hz, J 2 = 1,0 Hz, 1H, 1H 1H Hz 1H 1H, vol.586, issue.7, p.810512193440

1. Hz, 57 (s, 1H, NH), Hz, 1H), vol.7, issue.9, pp.314-315

. Mhz, CH 2 sucre ), CH sucreC arom, vol.20, issue.170, pp.2070-2076

D. Mhz, 19,9CH 3 acétate )CH 2 sucre ), CH sucre, vol.20, issue.145, p.6

. Masse-exacte, ES) : calculée pour C 30 H 27 N 3 NaO 13, 1442.

F. >-300°ct and J. =. , 21 (dd, J 1 = 12,5 Hz, J 2 = 2,5 Hz, 1H), 1H, vol.4, issue.5, p.2728

1. Hz and . Hz, s, 1H, NH), 1H Hz 1H Hz, vol.7, issue.9d 2, pp.3-73652640339

. Mhz, CH 3 acétate )CH 2 sucre ), CH sucre, vol.20, issue.1432, p.207

1. Hz and N. Hz, (s, 1H) Le proton de la fonction acide carboxylique n'est pas visible sur le spectre, 1H 1H 1H, vol.7, issue.8, p.59830818

1. Hz, Les protons de la fonction acide carboxylique et du groupement NH 2 ne sont pas visibles sur le spectre

D. Mhz, 100,0, p.3

. Masse-exacte, ES) calculée pour C 13 H 12 N 3, 1031.

1. Hz and 1. , s, 1H, NH, p.730388

D. Mhz, 106,0, p.30

P. Le and . Se-trouve-sous-la-forme-d, une solution 10X Pour le préparer, il faut le diluer au 1/10 dans de l'eau MilliQ et ajuster son pH à 7,4 par addition de 5 mL de NaOH 1N Solution de résazurine La solution de travail de résazurine est préparée en ajoutant 2 mL de la solution stock (solution de résazurine dans le PBS-D à 1,25 mg/mL) à 98 mL de milieu MEM complet sans rouge de phénol et sans SVF

L. Milieu-de-culture-utilisé-est-le-suivant, MEM (Eagle), GLUTAMAX I, Earle's salt supplémenté en, Sérum de veau foetal (SVF) 10%

K. Sur-pdgfr? and T. Egfr-l-'inhibiteur, ?M ; 0,1% DMSO), additionné de 200 ng de GST-RTK cyt dans un tampon phosphate (20 mM de MOPS ; 10 mM de MgCl 2 ; 10 mM de MnCl 2 ; 1 mM de DTT ; 2,5 mM d'EGTA ; 10 mM de ?-glycérophosphate ; 1 mM de Na 3 VO 4 et 1 mM de NaF) est immobilisé sur plaque. Après 5 minutes d'incubation, 2 ?g de GST-PLC-? et 2 ?Ci ? 33 P-ATP en présence de 2 ?M d'ATP non radioactif sont additionnés, Après 1 heure d'incubation à 37°C, de l'EDTA (100 mM au final) est ajouté pour stopper la réaction. Les puits sont lavés au PBS-tween et les plaques sont lues avec un lecteur micro? Wallac

P. Sur, 40 ?M) est mis à incuber à 30°C dans un mélange contenant 0,1 nM du domaine catalytique de PKA, 0,1 mM de ? 32 P-ATP, 2 mM de Mg(OAc) 2 , 70 ?M d'heptapeptide phosphoaccepteur «kemptide» dans 15 mM d'un milieu Hepes-NaOH (Ph 7,2) contenant 0,13 M de KCl, 0,3 mM d'EGTA, 0,3 mM d'EDTA et 1 mM de phosphate de sodium

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