. Ensoli, Native HIV-1 Tat Protein Targets Monocyte-Derived Dendritic Cells and Enhances Their Maturation, Function, and Antigen-Specific T Cell Responses, The Journal of Immunology, vol.168, pp.197-206, 2002.

. Aldovini, HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages, Nat. Med, vol.9, pp.191-197, 2003.

P. A. Battaglia, F. Longo, C. Ciotta, M. F. Del-grosso, E. Ambrosini et al., Genetic Tests to Reveal Tat Homodimer Formation and Select Tat Homodimer Inhibitor, Biochemical and Biophysical Research Communications, vol.201, issue.2, pp.701-708, 1994.
DOI : 10.1006/bbrc.1994.1757

R. Z. Dintzis, M. H. Middleton, and H. M. Dintzis, Studies on the immunogenicity and tolerogenicity of T-independent antigens, J. Immunol, vol.131, pp.2196-2203, 1983.

M. Malissen, A. Gillet, L. Ardouin, G. Bouvier, J. Trucy et al., Altered T cell development in mice with a targeted mutation of the CD3- epsilon gene, EMBO J, vol.14, pp.4641-4653, 1995.

F. P. Heinzel, M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley, Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets, Journal of Experimental Medicine, vol.169, issue.1, 1989.
DOI : 10.1084/jem.169.1.59

B. Maillère, J. Cotton, G. Mourier, M. Léonetti, S. Leroy et al., Role of thiols in the presentation of a snake toxin to murine T cells, J. Immunol, vol.150, pp.5270-5280, 1993.

M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini et al., Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size, J. Biol. Chem, vol.272, pp.11313-11320, 1997.

M. Rusnati, G. Tulipano, C. Urbinati, E. Tanghetti, R. Giuliani et al., The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists, Journal of Biological Chemistry, vol.273, issue.26, pp.16027-16037, 1998.
DOI : 10.1074/jbc.273.26.16027

M. Léonetti, A. Gadzinski, and E. G. Moine, Cell Surface Heparan Sulfate Proteoglycans Influence MHC Class II-Restricted Antigen Presentation, The Journal of Immunology, vol.185, issue.7, pp.3847-3856, 2010.
DOI : 10.4049/jimmunol.0902724

F. Sallusto, M. Cella, C. Danieli, and A. Lanzavecchia, Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products, Journal of Experimental Medicine, vol.182, issue.2, pp.389-400, 1995.
DOI : 10.1084/jem.182.2.389

A. Lanzavecchia, Mechanisms of antigen uptake for presentation, Current Opinion in Immunology, vol.8, issue.3, pp.348-354, 1996.
DOI : 10.1016/S0952-7915(96)80124-5

C. Watts, CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES, Annual Review of Immunology, vol.15, issue.1, pp.821-850, 1997.
DOI : 10.1146/annurev.immunol.15.1.821

C. Théry and S. Amigorena, The cell biology of antigen presentation in dendritic cells, Current Opinion in Immunology, vol.13, issue.1, pp.45-51, 2001.
DOI : 10.1016/S0952-7915(00)00180-1

F. Sallusto and A. Lanzavecchia, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, Journal of Experimental Medicine, vol.179, issue.4, pp.1109-1118, 1994.
DOI : 10.1084/jem.179.4.1109

P. W. Park, O. Reizes, and M. Bernfield, Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters, Journal of Biological Chemistry, vol.275, issue.39, pp.29923-29926, 2000.
DOI : 10.1074/jbc.R000008200

T. Wadström and A. Ljungh, Glycosaminoglycan-binding microbial proteins in tissue adhesion and invasion: key events in microbial pathogenicity, Journal of Medical Microbiology, vol.48, issue.3, pp.223-233, 1999.
DOI : 10.1099/00222615-48-3-223

F. D. Menozzi, K. Pethe, P. Bifani, F. Soncin, M. J. Brennan et al., Enhanced bacterial virulence through exploitation of host glycosaminoglycans, Molecular Microbiology, vol.43, issue.6, pp.1379-1386, 2002.
DOI : 10.1074/jbc.R000001200

M. Patel, M. Yanagishita, G. Roderiquez, D. C. Bou-habib, T. Oravecz et al., Cell-Surface Heparan Sulfate Proteoglycan Mediates HIV-1 Infection of T-Cell Lines, AIDS Research and Human Retroviruses, vol.9, issue.2, pp.167-174, 1993.
DOI : 10.1089/aid.1993.9.167

G. Roderiquez, T. Oravecz, M. Yanagishita, D. C. Bou-habib, H. Mostowski et al., Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41, J. Virol, vol.69, pp.2233-2239, 1995.

T. Compton, D. M. Nowlin, and N. R. Cooper, Initiation of Human Cytomegalovirus Infection Requires Initial Interaction with Cell Surface Heparan Sulfate, Virology, vol.193, issue.2, pp.834-841, 1993.
DOI : 10.1006/viro.1993.1192

B. A. Butcher, L. A. Sklar, L. C. Seamer, and R. H. Glew, Heparin enhances the interaction of infective Leishmania donovani promastigotes with mouse peritoneal macrophages. A fluorescence flow cytometric analysis, J. Immunol, vol.148, pp.2879-2886, 1992.

D. C. Love, J. D. Esko, and D. M. Mosser, A heparin-binding activity on Leishmania amastigotes which mediates adhesion to cellular proteoglycans, The Journal of Cell Biology, vol.123, issue.3, pp.759-766, 1993.
DOI : 10.1083/jcb.123.3.759

P. E. Gleizes, J. Noaillac-depeyre, F. Amalric, and N. Gas, Basic fibroblast growth factor (FGF-2) internalization through the heparan sulfate proteoglycansmediated pathway: an ultrastructural approach, Eur. J. Cell Biol, vol.66, pp.47-59, 1995.

P. E. Gleizes, J. Noaillac-depeyre, M. A. Dupont, and N. Gas, Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells, Eur. J. Cell Biol, vol.71, pp.144-153, 1996.

D. J. Carey, Syndecans: multifunctional cell-surface co-receptors, Biochemical Journal, vol.327, issue.1, pp.1-16, 1997.
DOI : 10.1042/bj3270001

M. Léonetti, L. Pillet, B. Maillère, H. Lamthanh, P. Frachon et al., Immunization with a peptide having both T cell and conformationally restricted B cell epitopes elicits neutralizing antisera against a snake neurotoxin, J. Immunol, vol.145, pp.4214-4221, 1990.

B. Maillère, J. Cotton, G. Mourier, M. Léonetti, S. Leroy et al., Role of thiols in the presentation of a snake toxin to murine T cells, J. Immunol, vol.150, pp.5270-5280, 1993.

R. Thai, G. Moine, M. Desmadril, D. Servent, J. L. Tarride et al., Antigen Stability Controls Antigen Presentation, Journal of Biological Chemistry, vol.279, issue.48, pp.50257-50266, 2004.
DOI : 10.1074/jbc.M405738200

A. Albini, R. Benelli, M. Presta, M. Rusnati, M. Ziche et al., HIV-tat protein is a heparinbinding angiogenic growth factor, Oncogene, vol.12, pp.289-297, 1996.

M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini et al., Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size, J. Biol. Chem, vol.272, pp.11313-11320, 1997.

H. C. Chang, F. Samaniego, B. C. Nair, L. Buonaguro, and B. Ensoli, HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region, AIDS, vol.11, issue.12, pp.1421-1431, 1997.
DOI : 10.1097/00002030-199712000-00006

M. Tyagi, M. Rusnati, M. Presta, and M. Giacca, Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans, Journal of Biological Chemistry, vol.276, issue.5, pp.3254-3261, 2001.
DOI : 10.1074/jbc.M006701200

H. V. Patel, A. A. Vyas, K. A. Vyas, Y. S. Liu, C. M. Chiang et al., Heparin and Heparan Sulfate Bind to Snake Cardiotoxin: SULFATED OLIGOSACCHARIDES AS A POTENTIAL TARGET FOR CARDIOTOXIN ACTION, Journal of Biological Chemistry, vol.272, issue.3, pp.1484-1492, 1997.
DOI : 10.1074/jbc.272.3.1484

M. Léonetti, J. Galon, R. Thai, C. Sautès-fridman, G. Moine et al., Presentation of Antigen in Immune Complexes Is Boosted by Soluble Bacterial Immunoglobulin Binding Proteins, The Journal of Experimental Medicine, vol.5, issue.8, pp.1217-1228, 1999.
DOI : 10.1084/jem.173.2.487

J. Kittiworakarn, A. Lecoq, G. Moine, R. Thai, E. Lajeunesse et al., HIV-1 Tat Raises an Adjuvant-free Humoral Immune Response Controlled by Its Core Region and Its Ability to Form Cysteine-mediated Oligomers, Journal of Biological Chemistry, vol.281, issue.6, pp.3105-3115, 2006.
DOI : 10.1074/jbc.M509899200

P. Kessler, F. Kotzyba-hibert, M. Leonetti, F. Bouet, P. Ringler et al., Synthesis of an Acetylcholine Receptor-Specific Toxin Derivative Regioselectively Labeled with an undecagold Cluster, Bioconjugate Chemistry, vol.5, issue.3, pp.199-204, 1994.
DOI : 10.1021/bc00027a004

B. Maillère, G. Mourier, J. Cotton, M. Hervé, S. Leroy et al., Probing immunogenicity of a T cell epitope by l-alanine and d-amino acid scanning, Molecular Immunology, vol.32, issue.14-15, pp.1073-1080, 1995.
DOI : 10.1016/0161-5890(95)00073-9

S. Amigorena, C. Bonnerot, J. R. Drake, D. Choquet, W. Hunziker et al., Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes, Science, vol.256, issue.5065, pp.1808-1812, 1992.
DOI : 10.1126/science.1535455

S. Amigorena, D. Lankar, V. Briken, L. Gapin, M. Viguier et al., Type II and III Receptors for Immunoglobulin G (IgG) Control the Presentation of Different T Cell Epitopes from Single IgG-complexed Antigens, The Journal of Experimental Medicine, vol.152, issue.4, pp.505-515, 1998.
DOI : 10.1084/jem.181.6.2253

A. Regnault, D. Lankar, V. Lacabanne, A. Rodriguez, C. Théry et al., Fc?? Receptor???mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I???restricted Antigen Presentation after Immune Complex Internalization, The Journal of Experimental Medicine, vol.70, issue.2, pp.371-380, 1999.
DOI : 10.1084/jem.184.3.863

J. Miller, J. A. Hatch, S. Simonis, and S. E. Cullen, Identification of the glycosaminoglycan-attachment site of mouse invariant-chain proteoglycan core protein by site-directed mutagenesis., Proc. Natl. Acad. Sci. USA, p.1369, 1988.
DOI : 10.1073/pnas.85.5.1359

M. F. Naujokas, M. Morin, M. S. Anderson, M. Peterson, and J. Miller, The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44, Cell, vol.74, issue.2, pp.257-268, 1993.
DOI : 10.1016/0092-8674(93)90417-O

B. Arunachalam, U. T. Phan, H. J. Geuze, and P. Cresswell, Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT), Proc. Natl. Acad. Sci. USA, pp.745-750, 2000.
DOI : 10.1073/pnas.97.2.745

M. Maric, B. Arunachalam, U. T. Phan, C. Dong, W. S. Garrett et al., Defective Antigen Processing in GILT-Free Mice, Science, vol.294, issue.5545, pp.1361-1365, 2001.
DOI : 10.1126/science.1065500

H. Mitsui, T. Inozume, R. Kitamura, N. Shibagaki, and S. Shimada, Polyarginine-Mediated Protein Delivery to Dendritic Cells Presents Antigen More Efficiently onto MHC Class I and Class II and Elicits Superior Antitumor Immunity, Journal of Investigative Dermatology, vol.126, issue.8, pp.1804-1812, 2006.
DOI : 10.1038/sj.jid.5700335

A. Fittipaldi, A. Ferrari, M. Zoppé, C. Arcangeli, V. Pellegrini et al., Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins, Journal of Biological Chemistry, vol.278, issue.36, pp.34141-34149, 2003.
DOI : 10.1074/jbc.M303045200

S. Futaki, Oligoarginine vectors for intracellular delivery: Design and cellular-uptake mechanisms, Biopolymers, vol.42, issue.3, pp.241-249, 2006.
DOI : 10.1002/bip.20421

J. M. Weaver, C. A. Lazarski, K. A. Richards, F. A. Chaves, S. A. Jenks et al., Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design, The Journal of Immunology, vol.181, issue.5, pp.3039-3048, 2008.
DOI : 10.4049/jimmunol.181.5.3039

L. Delamarre, M. Pack, H. Chang, I. Mellman, and E. S. Trombetta, Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate, Science, vol.307, issue.5715, pp.1630-1634, 2005.
DOI : 10.1126/science.1108003

Y. Wegrowski, A. L. Milard, G. Kotlarz, E. Toulmonde, F. X. Maquart et al., Cell surface proteoglycan expression during maturation of human monocytes-derived dendritic cells and macrophages, Clinical and Experimental Immunology, vol.43, issue.3, pp.485-493, 2006.
DOI : 10.1074/jbc.M106268200

A. Imberty, H. Lortat-jacob, and S. Pérez, Structural view of glycosaminoglycan???protein interactions, Carbohydrate Research, vol.342, issue.3-4, pp.430-439, 2007.
DOI : 10.1016/j.carres.2006.12.019

URL : https://hal.archives-ouvertes.fr/hal-00305588

D. Accapezzato, V. Visco, V. Francavilla, C. Molette, T. Donato et al., T cell responses against soluble antigens in vivo, The Journal of Experimental Medicine, vol.68, issue.6, pp.817-828, 2005.
DOI : 10.1083/jcb.137.1.93

A. L. Ackerman, A. Giodini, and P. Et-cresswell, A Role for the Endoplasmic Reticulum Protein Retrotranslocation Machinery during Crosspresentation by Dendritic Cells, Immunity, vol.25, issue.4, pp.607-617, 2006.
DOI : 10.1016/j.immuni.2006.08.017

A. L. Ackerman, C. Kyritsis, R. Tampé, and P. Et-cresswell, Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells, Nature Immunology, vol.170, issue.1, pp.107-113, 2005.
DOI : 10.1038/ni1147

A. L. Ackerman, C. Kyritsis, R. Tampé, and P. Et-cresswell, Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens, Proceedings of the National Academy of Sciences, vol.100, issue.22, pp.12889-12894, 2003.
DOI : 10.1073/pnas.1735556100

G. Y. Ahmed, H. H. Balkhy, S. Bafaqeer, B. Al-jasir, and A. Et-althaqafi, Acceptance and Adverse Effects of H1N1 Vaccinations Among a Cohort of National Guard Health Care Workers during the 2009 Hajj Season, BMC Research Notes, vol.4, issue.1, p.61, 2011.
DOI : 10.1086/656241

A. Albini, R. Benelli, M. Presta, M. Rusnati, M. Ziche et al., HIV-tat protein is a heparin-binding angiogenic growth factor, Oncogene, vol.12, pp.289-297, 1996.

A. Albini, R. Soldi, D. Giunciuglio, E. Giraudo, R. Benelli et al., The angiogenesis induced by HIV???1 Tat protein is mediated by the Flk???1/KDR receptor on vascular endothelial cells, Nature Medicine, vol.96, issue.12, pp.1371-1375, 1996.
DOI : 10.1056/NEJM199505043321801

A. Albini, R. Benelli, D. Giunciuglio, T. Cai, G. Mariani et al., Identification of a Novel Domain of HIV Tat Involved in Monocyte Chemotaxis, Journal of Biological Chemistry, vol.273, issue.26, pp.15895-15900, 1998.
DOI : 10.1074/jbc.273.26.15895

S. Amigorena, C. Bonnerot, J. R. Drake, D. Choquet, W. Hunziker et al., Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes, Science, vol.256, issue.5065, pp.1808-1812, 1992.
DOI : 10.1126/science.1535455

S. Amigorena and A. Et-savina, Intracellular mechanisms of antigen cross presentation in dendritic cells, Current Opinion in Immunology, vol.22, issue.1, pp.109-117, 2010.
DOI : 10.1016/j.coi.2010.01.022

K. M. Ansel, D. U. Lee, and A. Et-rao, An epigenetic view of helper T cell differentiation, Nature Immunology, vol.4, issue.7, pp.616-623, 2003.
DOI : 10.1038/ni0703-616

R. J. Apple, P. L. Domen, A. Muckerheide, and J. G. Et-michael, Cationization of protein antigens. IV. Increased antigen uptake by antigen-presenting cells, J. Immunol, vol.140, pp.3290-3295, 1988.

M. F. Bachmann and G. T. Et-jennings, Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns, Nature Reviews Immunology, vol.54, issue.11, pp.787-796, 2010.
DOI : 10.1038/nri2868

D. S. Bangari and S. K. Et-mittal, Development of nonhuman adenoviruses as vaccine vectors, Vaccine, vol.24, issue.7, pp.849-862, 2006.
DOI : 10.1016/j.vaccine.2005.08.101

R. B. Batchu, A. M. Moreno, S. M. Szmania, G. Bennett, G. C. Spagnoli et al., Protein Transduction of Dendritic Cells for NY-ESO-1-Based Immunotherapy of Myeloma, Cancer Research, vol.65, issue.21, pp.10041-10049, 2005.
DOI : 10.1158/0008-5472.CAN-05-1383

S. R. Bennett, F. R. Carbone, F. Karamalis, J. F. Miller, and W. R. Et-heath, T Cell Help, The Journal of Experimental Medicine, vol.152, issue.1, pp.65-70, 1997.
DOI : 10.1084/jem.169.3.603

P. Berche, Une histoire des microbes, 2007.

N. L. Bernasconi, E. Traggiai, and A. Et-lanzavecchia, Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells, Science, vol.298, issue.5601, pp.2199-2202, 2002.
DOI : 10.1126/science.1076071

H. Beuneu, Z. Garcia, and P. Et-bousso, Cutting Edge: Cognate CD4 Help Promotes Recruitment of Antigen-Specific CD8 T Cells around Dendritic Cells, The Journal of Immunology, vol.177, issue.3, pp.1406-1410, 2006.
DOI : 10.4049/jimmunol.177.3.1406

J. R. Bishop, M. Schuksz, and J. D. Et-esko, Heparan sulphate proteoglycans fine-tune mammalian physiology, Nature, vol.81, issue.7139, pp.1030-1037, 2007.
DOI : 10.1038/nature05817

L. H. Boise, A. J. Minn, P. J. Noel, C. H. June, M. A. Accavitti et al., CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL, Immunity, vol.3, issue.1, pp.87-98, 1995.
DOI : 10.1016/1074-7613(95)90161-2

L. C. Bonifaz, D. P. Bonnyay, A. Charalambous, D. I. Darguste, S. Fujii et al., In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination, The Journal of Experimental Medicine, vol.100, issue.6, pp.815-824, 2004.
DOI : 10.1084/jem.20021215

P. Bousso and E. Et-robey, Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes, Nature Immunology, vol.4, issue.6, pp.579-585, 2003.
DOI : 10.1038/ni928

L. Bozzacco, C. Trumpfheller, F. P. Siegal, S. Mehandru, M. Markowitz et al., DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes, Proc. Natl. Acad. Sci. U.S.A, pp.1289-1294, 2007.
DOI : 10.1073/pnas.0610383104

L. Buonaguro, G. Barillari, H. K. Chang, C. A. Bohan, V. Kao et al., Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines, J. Virol, vol.66, pp.7159-7167, 1992.

S. Burgdorf, A. Kautz, V. Böhnert, P. A. Knolle, and C. Et-kurts, Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation, Science, vol.316, issue.5824, pp.612-616, 2007.
DOI : 10.1126/science.1137971

K. Cahill, Cell-penetrating peptides, electroporation and drug delivery, IET Systems Biology, vol.4, issue.6, pp.367-378, 2010.
DOI : 10.1049/iet-syb.2010.0007

D. J. Campbell, C. H. Kim, and E. C. Et-butcher, Separable effector T cell populations specialized for B cell help or tissue inflammation, Nature Immunology, vol.141, issue.9, pp.876-881, 2001.
DOI : 10.1038/ni0901-876

G. R. Campbell and E. P. Et-loret, What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Retrovirology 6, p.50, 2009.

G. Carayanniotis and B. H. Et-barber, Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC, Nature, vol.327, issue.6117, pp.59-61, 1987.
DOI : 10.1038/327059a0

F. R. Carbone and M. J. Et-bevan, Class I-restricted processing and presentation of exogenous cell- associated antigen in vivo, Journal of Experimental Medicine, vol.171, issue.2, pp.377-387, 1990.
DOI : 10.1084/jem.171.2.377

A. Casadevall, E. Dadachova, and L. Et-pirofski, Passive antibody therapy for infectious diseases, Nature Reviews Microbiology, vol.25, issue.9, pp.695-703, 2004.
DOI : 10.1056/NEJM199311183292102

S. Celli, Z. Garcia, H. Beuneu, and P. Et-bousso, Decoding the dynamics of T cell???dendritic cell interactions in vivo, Immunological Reviews, vol.173, issue.1, pp.182-187, 2008.
DOI : 10.1038/ni742

S. Cemerski and A. Shaw, Immune synapses in T-cell activation, Current Opinion in Immunology, vol.18, issue.3, pp.298-304, 2006.
DOI : 10.1016/j.coi.2006.03.011

H. C. Chang, F. Samaniego, B. C. Nair, L. Buonaguro, and B. Et-ensoli, HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region, AIDS, vol.11, issue.12, pp.1421-1431, 1997.
DOI : 10.1097/00002030-199712000-00006

Y. Chiu, C. K. Ho, N. Saha, B. Schwer, S. Shuman et al., Tat Stimulates Cotranscriptional Capping of HIV mRNA, Molecular Cell, vol.10, issue.3, pp.585-597, 2002.
DOI : 10.1016/S1097-2765(02)00630-5

S. L. Chudasama, B. Espinasse, F. Hwang, R. Qi, M. Joglekar et al., Heparin modifies the immunogenicity of positively charged proteins, Blood, vol.116, issue.26, pp.2010-2016, 2010.
DOI : 10.1182/blood-2010-06-292938

R. L. Coffman, A. Sher, and R. A. Et-seder, Vaccine Adjuvants: Putting Innate Immunity to Work, Immunity, vol.33, issue.4, pp.492-503, 2010.
DOI : 10.1016/j.immuni.2010.10.002

J. G. Cyster, CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS, Annual Review of Immunology, vol.23, issue.1, pp.127-159, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115628

D. H. Dandekar, K. N. Ganesh, and D. Et-mitra, HIV-1 Tat directly binds to NF??B enhancer sequence: role in viral and cellular gene expression, Nucleic Acids Research, vol.32, issue.4, pp.1270-1278, 2004.
DOI : 10.1093/nar/gkh289

J. Dannull, Z. Su, D. Rizzieri, B. K. Yang, D. Coleman et al., Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells, Journal of Clinical Investigation, vol.115, issue.12, pp.3623-3633, 2005.
DOI : 10.1172/JCI25947

S. Davey, State of the world's vaccines and immunization (World Health Organization, 2009.

A. I. Dayton, J. G. Sodroski, C. A. Rosen, W. C. Goh, and W. A. Et-haseltine, The trans-activator gene of the human T cell lymphotropic virus type III is required for replication, Cell, vol.44, issue.6, pp.941-947, 1986.
DOI : 10.1016/0092-8674(86)90017-6

D. Groot, A. S. Mcmurry, J. Et-moise, and L. , Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates, Current Opinion in Pharmacology, vol.8, pp.620-626, 2008.

E. K. Deenick, J. Hasbold, and P. D. Et-hodgkin, Decision criteria for resolving isotype switching conflicts by B cells, European Journal of Immunology, vol.171, issue.10, pp.2949-2955, 2005.
DOI : 10.1002/eji.200425719

L. Delamarre, R. Couture, I. Mellman, and E. S. Et-trombetta, Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis, The Journal of Experimental Medicine, vol.234, issue.9, pp.2049-2055, 2006.
DOI : 10.1016/0006-3002(59)90407-X

L. Delamarre, M. Pack, H. Chang, I. Mellman, and E. S. Et-trombetta, Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate, Science, vol.307, issue.5715, pp.1630-1634, 2005.
DOI : 10.1126/science.1108003

Y. Delneste, G. Magistrelli, J. Gauchat, J. Haeuw, J. Aubry et al., Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation, Immunity, vol.17, issue.3, pp.353-362, 2002.
DOI : 10.1016/S1074-7613(02)00388-6

R. Z. Dintzis, M. H. Middleton, and H. M. Et-dintzis, Studies on the immunogenicity and tolerogenicity of T-independent antigens, J. Immunol, vol.131, pp.2196-2203, 1983.

J. G. Dohlman, D. J. Pillion, L. A. Rokeach, and M. P. Et-ramprasad, Identification of macrophage cell-surface binding sites for cationized bovine serum albumin, Biochemical and Biophysical Research Communications, vol.181, issue.2, pp.787-796, 1991.
DOI : 10.1016/0006-291X(91)91259-F

B. Ensoli, L. Buonaguro, G. Barillari, V. Fiorelli, R. Gendelman et al., Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation, J. Virol, vol.67, pp.277-287, 1993.

B. Ensoli, R. Gendelman, P. Markham, V. Fiorelli, S. Colombini et al., Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma, Nature, vol.371, issue.6499, pp.674-680, 1994.
DOI : 10.1038/371674a0

E. Fanales-belasio, S. Moretti, F. Nappi, G. Barillari, F. Micheletti et al., Native HIV-1 Tat Protein Targets Monocyte-Derived Dendritic Cells and Enhances Their Maturation, Function, and Antigen-Specific T Cell Responses, The Journal of Immunology, vol.168, issue.1, pp.197-206, 2002.
DOI : 10.4049/jimmunol.168.1.197

F. Fenner, Smallpox and its eradication (World Health Organization, 1988.

O. J. Finn, Cancer vaccines: between the idea and the reality, Nature Reviews Immunology, vol.3, issue.8, pp.630-641, 2003.
DOI : 10.1038/nri1150

A. C. Fluckiger, Z. Li, R. M. Kato, M. I. Wahl, H. D. Ochs et al., Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation, The EMBO Journal, vol.17, issue.7, 1973.
DOI : 10.1093/emboj/17.7.1973

A. D. Frankel and C. O. Et-pabo, Cellular uptake of the tat protein from human immunodeficiency virus, Cell, vol.55, issue.6, pp.1189-1193, 1988.
DOI : 10.1016/0092-8674(88)90263-2

H. A. Gans, Y. Maldonado, L. L. Yasukawa, J. Beeler, S. Audet et al., IL-12, IFN-gamma, and T cell proliferation to measles in immunized infants, J. Immunol, vol.162, pp.5569-5575, 1999.

R. Gavioli, S. Cellini, A. Castaldello, R. Voltan, E. Gallerani et al., The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS, Vaccine, vol.26, issue.5, pp.727-737, 2008.
DOI : 10.1016/j.vaccine.2007.11.040

R. N. Germain, Vaccines and the Future of Human Immunology, Immunity, vol.33, issue.4, pp.441-450, 2010.
DOI : 10.1016/j.immuni.2010.09.014

S. Gillis and K. A. Et-smith, Long term culture of tumour-specific cytotoxic T cells, Nature, vol.118, issue.5616, pp.154-156, 1977.
DOI : 10.1016/0042-6822(70)90362-4

M. P. Girard, S. K. Osmanov, and M. P. Et-kieny, A review of vaccine research and development: The human immunodeficiency virus (HIV)???, Vaccine, vol.24, issue.19, pp.4062-4081, 2006.
DOI : 10.1016/j.vaccine.2006.02.031

N. Guérin, Histoire de??la??vaccination: de??l'empirisme aux??vaccins recombinants, La Revue de M??decine Interne, vol.28, issue.1, pp.3-8, 2007.
DOI : 10.1016/j.revmed.2006.09.024

D. Hawiger, K. Inaba, Y. Dorsett, M. Guo, K. Mahnke et al., Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo, The Journal of Experimental Medicine, vol.159, issue.6, pp.769-779, 2001.
DOI : 10.1034/j.1600-065X.2000.917309.x

H. D. Herce, A. E. Garcia, J. Litt, R. S. Kane, P. Martin et al., Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides, Biophysical Journal, vol.97, issue.7, pp.910-1736, 2009.
DOI : 10.1016/j.bpj.2009.05.066

M. Houde, S. Bertholet, E. Gagnon, S. Brunet, G. Goyette et al., Phagosomes are competent organelles for antigen cross-presentation, Nature, vol.425, issue.6956, pp.402-406, 2003.
DOI : 10.1038/nature01912

A. M. Intlekofer, N. Takemoto, E. J. Wherry, S. A. Longworth, J. T. Northrup et al., Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin, Nature Immunology, vol.174, issue.12, pp.1236-1244, 2005.
DOI : 10.1038/ni1268

E. Izmailova, F. M. Bertley, Q. Huang, N. Makori, C. J. Miller et al., HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages, Nature Medicine, vol.9, issue.2, pp.191-197, 2003.
DOI : 10.1038/nm822

A. Jäger and V. K. Et-kuchroo, Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation, Scandinavian Journal of Immunology, vol.59, issue.Suppl., pp.173-184, 2010.
DOI : 10.1111/j.1365-3083.2010.02432.x

C. Janeway, Immunobiology: the immune system in health and disease, 2005.

R. M. Johnson, S. D. Harrison, and D. Et-maclean, Therapeutic Applications of Cell-Penetrating Peptides, Methods Mol. Biol, vol.683, pp.535-551, 2011.
DOI : 10.1007/978-1-60761-919-2_38

M. K. Johri, R. Mishra, C. Chhatbar, S. K. Unni, and S. K. Et-singh, Tits and bits of HIV Tat protein, Expert Opinion on Biological Therapy, vol.128, issue.3, pp.269-283, 2011.
DOI : 10.1073/pnas.87.9.3479

E. A. Joura, S. Leodolter, M. Hernandez-avila, C. M. Wheeler, G. Perez et al., Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials, The Lancet, vol.369, issue.9574, pp.1693-1702, 2007.
DOI : 10.1016/S0140-6736(07)60777-6

S. Jung, D. Unutmaz, P. Wong, G. Sano, K. De-los-santos et al., In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens, Immunity, vol.17, issue.2, pp.211-220, 2002.
DOI : 10.1016/S1074-7613(02)00365-5

S. Kanazawa, T. Okamoto, and B. M. Et-peterlin, Tat Competes with CIITA for the Binding to P-TEFb and Blocks the Expression of MHC Class II Genes in HIV Infection, Immunity, vol.12, issue.1, pp.61-70, 2000.
DOI : 10.1016/S1074-7613(00)80159-4

S. H. Kaufmann, Envisioning future strategies for vaccination against tuberculosis, Nature Reviews Immunology, vol.115, issue.9, pp.699-704, 2006.
DOI : 10.1038/nri1920

D. T. Kim, D. J. Mitchell, D. G. Brockstedt, L. Fong, G. P. Nolan et al., Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide, J. B. J. Immunol, vol.159, pp.1666-1668, 1997.

J. Kittiworakarn, A. Lecoq, G. Moine, R. Thai, E. Lajeunesse et al., HIV-1 Tat Raises an Adjuvant-free Humoral Immune Response Controlled by Its Core Region and Its Ability to Form Cysteine-mediated Oligomers, Journal of Biological Chemistry, vol.281, issue.6, pp.3105-3115, 2006.
DOI : 10.1074/jbc.M509899200

K. Kretschmer, I. Apostolou, D. Hawiger, K. Khazaie, M. C. Nussenzweig et al., Inducing and expanding regulatory T cell populations by foreign antigen, Nature Immunology, vol.5, issue.12, pp.1219-1227, 2005.
DOI : 10.1038/ni1265

J. Kreuger, D. Spillmann, J. Li, and U. Lindahl, Interactions between heparan sulfate and proteins: the concept of specificity, The Journal of Cell Biology, vol.99, issue.3, pp.323-327, 2006.
DOI : 10.1172/JCI200113662

A. Lanzavecchia, Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes, Annual Review of Immunology, vol.8, issue.1, pp.773-793, 1990.
DOI : 10.1146/annurev.iy.08.040190.004013

A. Lanzavecchia and F. Et-sallusto, Human B cell memory, Current Opinion in Immunology, vol.21, issue.3, pp.298-304, 2009.
DOI : 10.1016/j.coi.2009.05.019

A. Lanzavecchia and F. Et-sallusto, Toll-like receptors and innate immunity in B-cell activation and antibody responses, Current Opinion in Immunology, vol.19, issue.3, pp.268-274, 2007.
DOI : 10.1016/j.coi.2007.04.002

C. Leclerc, L???apport des nouvelles technologies en vaccinologie, m??decine/sciences, vol.23, issue.4, pp.386-390, 2007.
DOI : 10.1051/medsci/2007234386

A. Lecoq, G. Moine, L. Bellanger, P. Drevet, R. Thai et al., Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy, Vaccine, vol.26, issue.21, pp.2615-2626, 2008.
DOI : 10.1016/j.vaccine.2008.02.057

M. Léonetti, A. Gadzinski, and G. Et-moine, Cell Surface Heparan Sulfate Proteoglycans Influence MHC Class II-Restricted Antigen Presentation, The Journal of Immunology, vol.185, issue.7, pp.3847-3856, 2010.
DOI : 10.4049/jimmunol.0902724

M. M. Levine, G. Dougan, and M. F. Et-good, New Generation Vaccines (Informa Healthcare), 2009.

S. Li, E. Locke, J. Bruder, D. Clarke, D. L. Doolan et al., Viral vectors for malaria vaccine development, Vaccine, vol.25, issue.14, pp.2567-2574, 2007.
DOI : 10.1016/j.vaccine.2006.07.035

S. Loureiro, J. Ren, P. Phapugrangkul, C. A. Colaco, C. R. Bailey et al., Adjuvant free immunisation with Hemagglutinin-Fc fusion proteins as an approach to influenza vaccines, J Virol, 2010.

A. H. Lucas and D. C. Et-reason, Polysaccharide vaccines as probes of antibody repertoires in man, Immunological Reviews, vol.150, issue.1, pp.89-104, 1999.
DOI : 10.1016/0022-2836(87)90412-8

M. Lundberg, S. Wikström, and M. Et-johansson, Cell surface adherence and endocytosis 165, 2003.

I. C. Maclennan, Germinal Centers, Annual Review of Immunology, vol.12, issue.1, pp.117-139, 1994.
DOI : 10.1146/annurev.iy.12.040194.001001

I. C. Maclennan, K. Toellner, A. F. Cunningham, K. Serre, D. M. Sze et al., Extrafollicular antibody responses, Immunological Reviews, vol.246, issue.1, pp.8-18, 2003.
DOI : 10.1016/S0952-7915(98)80162-3

B. Maillère, J. Cotton, G. Mourier, M. Léonetti, S. Leroy et al., Role of thiols in the presentation of a snake toxin to murine T cells, J. Immunol, vol.150, pp.5270-5280, 1993.

B. Maillère, G. Mourier, J. Cotton, M. Hervé, S. Leroy et al., Probing immunogenicity of a T cell epitope by l-alanine and d-amino acid scanning, Molecular Immunology, vol.32, issue.14-15, pp.1073-1080, 1995.
DOI : 10.1016/0161-5890(95)00073-9

R. A. Maldonado, D. J. Irvine, R. Schreiber, and L. H. Et-glimcher, A role for the immunological synapse in lineage commitment of CD4 lymphocytes, Nature, vol.166, issue.7008, pp.527-532, 2004.
DOI : 10.1016/S0166-2236(02)02215-4

M. Mamani-matsuda, A. Cosma, S. Weller, A. Faili, C. Staib et al., The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells, Blood, vol.111, issue.9, pp.4653-4659, 2008.
DOI : 10.1182/blood-2007-11-123844

URL : https://hal.archives-ouvertes.fr/inserm-00311504

N. Manjunath, P. Shankar, J. Wan, W. Weninger, M. A. Crowley et al., Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes, Journal of Clinical Investigation, vol.108, issue.6, pp.871-878, 2001.
DOI : 10.1172/JCI13296

W. A. Marasco and J. Et-sui, The growth and potential of human antiviral monoclonal antibody therapeutics, Nature Biotechnology, vol.49, issue.12, pp.1421-1434, 2007.
DOI : 10.1016/S0022-1759(99)00223-9

M. Maruyama, K. P. Lam, and K. Et-rajewsky, Memory B-cell persistence is independent of persisting immunizing antigen, Nature, vol.407, pp.636-642, 2000.

K. Mayol, S. Munier, A. Beck, B. Verrier, and C. Et-guillon, Design and characterization of an HIV-1 Tat mutant: Inactivation of viral and cellular functions but not antigenicity, Vaccine, vol.25, issue.32, pp.6047-6060, 2007.
DOI : 10.1016/j.vaccine.2007.05.048

I. B. Mazo, M. Honczarenko, H. Leung, L. L. Cavanagh, R. Bonasio et al., Bone Marrow Is a Major Reservoir and Site of Recruitment for Central Memory CD8+ T Cells, Immunity, vol.22, issue.2, pp.259-270, 2005.
DOI : 10.1016/j.immuni.2005.01.008

A. S. Mckee, M. W. Munks, and P. Et-marrack, How Do Adjuvants Work? Important Considerations for New Generation Adjuvants, Immunity, vol.27, issue.5, pp.687-690, 2007.
DOI : 10.1016/j.immuni.2007.11.003

M. J. Miller, S. H. Wei, I. Parker, and M. D. Et-cahalan, Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node, Science, vol.296, issue.5574, pp.1869-1873, 2002.
DOI : 10.1126/science.1070051

M. Wols, H. A. Underhill, G. H. Kansas, G. S. Et-witte, and P. L. , The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity, The Journal of Immunology, vol.169, issue.8, pp.4213-4221, 2002.
DOI : 10.4049/jimmunol.169.8.4213

H. Mitsui, T. Inozume, R. Kitamura, N. Shibagaki, and S. Et-shimada, Polyargininemediated protein delivery to dendritic cells presents antigen more efficiently onto MHC class 166, 2006.

B. Molon, G. Gri, M. Bettella, C. Gómez-moutón, A. Lanzavecchia et al., T cell costimulation by chemokine receptors, Nature Immunology, vol.173, issue.5, pp.465-471, 2005.
DOI : 10.1084/jem.182.2.389

J. J. Mond, Q. Vos, A. Lees, and C. M. Et-snapper, T cell independent antigens, Current Opinion in Immunology, vol.7, issue.3, pp.349-354, 1995.
DOI : 10.1016/0952-7915(95)80109-X

M. W. Moore, F. R. Carbone, and M. J. Et-bevan, Introduction of soluble protein into the class I pathway of antigen processing and presentation, Cell, vol.54, issue.6, pp.777-785, 1988.
DOI : 10.1016/S0092-8674(88)91043-4

J. R. Mora and U. H. Et-von-andrian, T-cell homing specificity and plasticity: new concepts and future challenges, Trends in Immunology, vol.27, issue.5, pp.235-243, 2006.
DOI : 10.1016/j.it.2006.03.007

J. R. Mora, M. R. Bono, N. Manjunath, W. Weninger, L. L. Cavanagh et al., Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells, Nature, vol.424, issue.6944, pp.88-93, 2003.
DOI : 10.1038/nature01726

J. R. Mora, G. Cheng, D. Picarella, M. Briskin, N. Buchanan et al., Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues, The Journal of Experimental Medicine, vol.14, issue.2, pp.303-316, 2005.
DOI : 10.1084/jem.189.1.37

M. Moser and O. Et-leo, Key concepts in immunology, Vaccine, vol.28, pp.2-13, 2010.
DOI : 10.1016/j.vaccine.2010.07.022

A. M. Moulin, L'aventure de la vaccination (Fayard), 1996.

V. R. Moulton and D. L. Et-farber, Committed to memory: lineage choices for activated T cells, Trends in Immunology, vol.27, issue.6, pp.261-267, 2006.
DOI : 10.1016/j.it.2006.04.006

A. Muckerheide, R. J. Apple, A. J. Pesce, and J. G. Et-michael, Cationization of protein antigens. I. Alteration of immunogenic properties, J. Immunol, vol.138, pp.833-837, 1987.

L. Muniz, S. Egloff, B. Ughy, B. E. Jády, and T. Et-kiss, Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat, PLoS Pathogens, vol.66, issue.10, 2010.
DOI : 10.1371/journal.ppat.1001152.s001

URL : https://hal.archives-ouvertes.fr/hal-00611875

S. E. Mutsaers and J. M. Et-papadimitriou, Surface charge of macrophages and their interaction with charged particles, J. Leukoc. Biol, vol.44, pp.17-26, 1988.

S. Nagata and P. Et-golstein, The Fas death factor, Science, vol.267, issue.5203, pp.1449-1456, 1995.
DOI : 10.1126/science.7533326

J. Neijssen, C. Herberts, J. W. Drijfhout, E. Reits, L. Janssen et al., Cross-presentation by intercellular peptide transfer through gap junctions, Nature, vol.64, issue.7029, pp.83-88, 2005.
DOI : 10.1073/pnas.0308345101

K. Palucka, J. Banchereau, and I. Et-mellman, Designing Vaccines Based on Biology of Human Dendritic Cell Subsets, Immunity, vol.33, issue.4, pp.464-478, 2010.
DOI : 10.1016/j.immuni.2010.10.007

K. A. Pape, D. M. Catron, A. A. Itano, and M. K. Et-jenkins, The Humoral Immune Response Is Initiated in Lymph Nodes by B Cells that Acquire Soluble Antigen Directly in the Follicles, Immunity, vol.26, issue.4, pp.491-502, 2007.
DOI : 10.1016/j.immuni.2007.02.011

E. Paramithiotis and M. D. Et-cooper, Memory B lymphocytes migrate to bone marrow in humans, Proceedings of the National Academy of Sciences, vol.94, issue.1, pp.208-212, 1997.
DOI : 10.1073/pnas.94.1.208

P. W. Park, O. Reizes, and M. Et-bernfield, Cell Surface Heparan Sulfate Proteoglycans: Selective Regulators of Ligand-Receptor Encounters, Journal of Biological Chemistry, vol.275, issue.39, pp.29923-29926, 2000.
DOI : 10.1074/jbc.R000008200

W. E. Paul, Fundamental immunology, 2008.

T. Plénat, S. Deshayes, S. Boichot, P. E. Milhiet, R. B. Cole et al., Interaction of Primary Amphipathic Cell-Penetrating Peptides with Phospholipid-Supported Monolayers, Langmuir, vol.20, issue.21, pp.9255-9261, 2004.
DOI : 10.1021/la048622b

S. A. Plotkin, Vaccines: past, present and future, Nature Medicine, vol.28, issue.4s, 2005.
DOI : 10.1023/A:1013607400040

R. G. Ptak, W. Fu, B. E. Sanders-beer, J. E. Dickerson, J. W. Pinney et al., Cataloguing the HIV Type 1 Human Protein Interaction Network, AIDS Research and Human Retroviruses, vol.24, issue.12, pp.1497-1502, 2008.
DOI : 10.1089/aid.2008.0113

V. Ramakrishna, J. F. Treml, L. Vitale, J. E. Connolly, T. O-'neill et al., Mannose Receptor Targeting of Tumor Antigen pmel17 to Human Dendritic Cells Directs Anti-Melanoma T Cell Responses via Multiple HLA Molecules, The Journal of Immunology, vol.172, issue.5, pp.2845-2852, 2004.
DOI : 10.4049/jimmunol.172.5.2845

T. M. Rana and K. Et-jeang, Biochemical and Functional Interactions between HIV-1, 1999.

R. Rappuoli, Reverse vaccinology, Current Opinion in Microbiology, vol.3, issue.5, pp.445-450, 2000.
DOI : 10.1016/S1369-5274(00)00119-3

R. Rappuoli, Bridging the knowledge gaps in vaccine design, Nature Biotechnology, vol.37, issue.12, pp.1361-1366, 2007.
DOI : 10.1038/nrmicro1688

F. Rayne, S. Debaisieux, A. Bonhoure, and B. Et-beaumelle, HIV-1 Tat is unconventionally secreted through the plasma membrane, Cell Biology International, vol.21, issue.4, pp.409-413, 2010.
DOI : 10.1091/mbc.E03-12-0921

URL : https://hal.archives-ouvertes.fr/hal-00509057

A. Regnault, D. Lankar, V. Lacabanne, A. Rodriguez, C. Théry et al., Fc?? Receptor???mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I???restricted Antigen Presentation after Immune Complex Internalization, The Journal of Experimental Medicine, vol.70, issue.2, pp.371-380, 1999.
DOI : 10.1084/jem.184.3.863

S. Rerks-ngarm, P. Pitisuttithum, S. Nitayaphan, J. Kaewkungwal, J. Chiu et al., Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand, New England Journal of Medicine, vol.361, issue.23, pp.2209-2220, 2009.
DOI : 10.1056/NEJMoa0908492

S. Riedel, Edward Jenner and the history of smallpox and vaccination, Proc, vol.18, pp.21-25, 2005.

S. Riedel, Edward Jenner and the history of smallpox and vaccination, Proc, vol.18, pp.21-25, 2005.

D. M. Roberts, A. Nanda, M. J. Havenga, P. Abbink, D. M. Lynch et al., Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity, Nature, vol.79, issue.7090, pp.239-243, 2006.
DOI : 10.1038/nature04721

M. Rusnati, G. Tulipano, C. Urbinati, E. Tanghetti, R. Giuliani et al., The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists, Journal of Biological Chemistry, vol.273, issue.26, pp.16027-16037, 1998.
DOI : 10.1074/jbc.273.26.16027

M. Rusnati, D. Coltrini, P. Oreste, G. Zoppetti, A. Albini et al., Interaction of HIV-1 Tat Protein with Heparin, Journal of Biological Chemistry, vol.272, pp.11313-11320, 1997.

F. Sallusto, D. Lenig, R. Förster, M. Lipp, and A. Et-lanzavecchia, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, vol.9, issue.6754, pp.708-712, 1999.
DOI : 10.1038/44385

A. Savina, C. Jancic, S. Hugues, P. Guermonprez, P. Vargas et al., NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells, Cell, vol.126, issue.1, pp.205-218, 2006.
DOI : 10.1016/j.cell.2006.05.035

K. W. Schjetne, A. B. Fredriksen, and B. Et-bogen, Delivery of Antigen to CD40 Induces Protective Immune Responses against Tumors, The Journal of Immunology, vol.178, issue.7, pp.4169-4176, 2007.
DOI : 10.4049/jimmunol.178.7.4169

M. Schutze-redelmeier, H. Gournier, F. Garcia-pons, M. Moussa, A. Joliot et al., Introduction of exogenous antigens into the MHC class I processing and presentation pathway by Drosophila antennapedia homeodomain primes cytotoxic T cells in vivo, The Journal of Immunology, vol.157, pp.650-655, 1996.

A. Shahinian, K. Pfeffer, K. Lee, T. Kundig, K. Kishihara et al., Differential T cell costimulatory requirements in CD28-deficient mice, Science, vol.261, issue.5121, pp.609-612, 1993.
DOI : 10.1126/science.7688139

L. Shen and K. L. Et-rock, Cellular protein is the source of cross-priming antigen in vivo, Proceedings of the National Academy of Sciences, vol.101, issue.9, pp.3035-3040, 2004.
DOI : 10.1073/pnas.0308345101

L. Shen, L. J. Sigal, M. Boes, and K. L. Et-rock, Important Role of Cathepsin S in Generating Peptides for TAP-Independent MHC Class I Crosspresentation In Vivo, Immunity, vol.21, issue.2, pp.155-165, 2004.
DOI : 10.1016/j.immuni.2004.07.004

N. Shibagaki and M. C. Et-udey, Dendritic Cells Transduced with Protein Antigens 169, 2002.

F. P. Siegal, N. Kadowaki, M. Shodell, P. A. Fitzgerald-bocarsly, K. Shah et al., The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood, Science, vol.284, issue.5421, pp.1835-1837, 1999.
DOI : 10.1126/science.284.5421.1835

D. P. Snider and D. M. Et-segal, Efficiency of antigen presentation after antigen targeting to surface IgD, IgM, MHC, Fc gamma RII, and B220 molecules on murine splenic B cells, J. Immunol, vol.143, pp.59-65, 1989.

R. Steinbrook, One Step Forward, Two Steps Back ??? Will There Ever Be an AIDS Vaccine?, New England Journal of Medicine, vol.357, issue.26, pp.2653-2655, 2007.
DOI : 10.1056/NEJMp0708117

K. Strebel, Virus???host interactions, AIDS, vol.17, issue.Supplement 4, pp.25-34, 2003.
DOI : 10.1097/00002030-200317004-00003

B. M. Sullivan, A. Juedes, S. J. Szabo, M. Von-herrath, and L. H. Et-glimcher, Antigen-driven effector CD8 T cell function regulated by T-bet, Proceedings of the National Academy of Sciences, vol.100, issue.26, pp.15818-15823, 2003.
DOI : 10.1073/pnas.2636938100

P. J. Tacken, I. J. De-vries, K. Gijzen, B. Joosten, D. Wu et al., Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody, Blood, vol.106, issue.4, pp.1278-1285, 2005.
DOI : 10.1182/blood-2005-01-0318

P. J. Tacken, B. Joosten, A. Reddy, D. Wu, A. Eek et al., No Advantage of Cell-Penetrating Peptides over Receptor-Specific Antibodies in Targeting Antigen to Human Dendritic Cells for Cross-Presentation, The Journal of Immunology, vol.180, issue.11, pp.7687-7696, 2008.
DOI : 10.4049/jimmunol.180.11.7687

P. J. Tacken, I. J. De-vries, R. Torensma, and C. G. Et-figdor, Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting, Nature Reviews Immunology, vol.14, issue.10, pp.790-802, 2007.
DOI : 10.1038/nri2173

T. H. Tahirov, N. D. Babayeva, K. Varzavand, J. J. Cooper, S. C. Sedore et al., Crystal structure of HIV-1 Tat complexed with human P-TEFb, Nature, vol.448, issue.7299, pp.747-751, 2010.
DOI : 10.1038/nature09131

W. Timens, A. Boes, T. Rozeboom-uiterwijk, and S. Et-poppema, Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response, J. Immunol, vol.143, pp.3200-3206, 1989.

A. A. Tobian, C. V. Harding, and D. H. Et-canaday, Mycobacterium tuberculosis Heat Shock Fusion Protein Enhances Class I MHC Cross-Processing and -Presentation by B Lymphocytes, The Journal of Immunology, vol.174, issue.9, pp.5209-5214, 2005.
DOI : 10.4049/jimmunol.174.9.5209

N. Touret, P. Paroutis, M. Terebiznik, R. E. Harrison, S. Trombetta et al., Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation, Cell, vol.123, issue.1, pp.157-170, 2005.
DOI : 10.1016/j.cell.2005.08.018

URL : https://hal.archives-ouvertes.fr/hal-00079556

E. Tritto, F. Mosca, and E. Et-de-gregorio, Mechanism of action of licensed vaccine adjuvants, Vaccine, vol.27, issue.25-26, pp.3331-3334, 2009.
DOI : 10.1016/j.vaccine.2009.01.084

M. Tyagi, M. Rusnati, M. Presta, and M. Et-giacca, Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans, Journal of Biological Chemistry, vol.276, issue.5, pp.3254-3261, 2001.
DOI : 10.1074/jbc.M006701200

H. Ueno, E. Klechevsky, R. Morita, C. Aspord, T. Cao et al., Dendritic cell subsets in health and disease, Immunological Reviews, vol.5, issue.1, pp.118-142, 2007.
DOI : 10.1182/blood-2005-01-0318

H. Ueno, E. Klechevsky, N. Schmitt, L. Ni, A. Flamar et al., Targeting human dendritic cell subsets for improved vaccines, Seminars in Immunology, vol.23, issue.1, pp.21-27, 2011.
DOI : 10.1016/j.smim.2011.01.004

J. Valladeau and S. Et-saeland, Cutaneous dendritic cells, Seminars in Immunology, vol.17, issue.4, pp.273-283, 2005.
DOI : 10.1016/j.smim.2005.05.009

L. H. Vandenberghe, L. Wang, S. Somanathan, Y. Zhi, J. Figueredo et al., Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid, Nature Medicine, vol.335, issue.8, pp.967-971, 2006.
DOI : 10.1038/nm1445

P. Veschambre, A. Roisin, and P. Et-jalinot, Biochemical and functional interaction of the human immunodeficiency virus type 1 Tat transactivator with the general transcription factor TFIIB., Journal of General Virology, vol.78, issue.9, pp.2235-2245, 1997.
DOI : 10.1099/0022-1317-78-9-2235

B. Vingert, O. Adotevi, D. Patin, S. Jung, P. Shrikant et al., The Shiga toxin B-subunit targets antigenin vivo to dendritic cells and elicits anti-tumor immunity, European Journal of Immunology, vol.145, issue.5, pp.1124-1135, 2006.
DOI : 10.1002/eji.200535443

C. G. Vinuesa, S. G. Tangye, B. Moser, and . Et-mackay, Follicular B helper T cells in antibody responses and autoimmunity, Nature Reviews Immunology, vol.84, issue.11, pp.853-865, 2005.
DOI : 10.1002/eji.200425442

J. M. Vyas, A. G. Van-der-veen, and H. L. Et-ploegh, The known unknowns of antigen processing and presentation, Nature Reviews Immunology, vol.27, issue.8, pp.607-618, 2008.
DOI : 10.1038/nri2368

H. Wang, M. N. Griffiths, D. R. Burton, and P. Et-ghazal, Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization, Proceedings of the National Academy of Sciences, vol.97, issue.2, pp.847-852, 2000.
DOI : 10.1073/pnas.97.2.847

N. M. Wassef and S. F. Et-plaeger, Cytokines as adjuvants for HIV DNA vaccines, Clinical and Applied Immunology Reviews, vol.2, issue.4-5, pp.229-240
DOI : 10.1016/S1529-1049(02)00048-X

W. C. Weldon, B. Wang, M. P. Martin, D. G. Koutsonanos, I. Skountzou et al., Enhanced Immunogenicity of Stabilized Trimeric Soluble Influenza Hemagglutinin, PLoS ONE, vol.283, issue.4, 2010.
DOI : 10.1371/journal.pone.0012466.g006

A. D. Wells, H. Gudmundsdottir, and L. A. Et-turka, Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response., Journal of Clinical Investigation, vol.100, issue.12, pp.3173-3183, 1997.
DOI : 10.1172/JCI119873

M. O. Westendorp, R. Frank, C. Ochsenbauer, K. Stricker, J. Dhein et al., Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120, Nature, vol.375, issue.6531, pp.497-500, 1995.
DOI : 10.1038/375497a0

E. J. Wherry, V. Teichgräber, T. C. Becker, D. Masopust, S. M. Kaech et al., Lineage relationship and protective immunity of memory CD8 T cell subsets, Nature Immunology, vol.4, issue.3, pp.225-234, 2003.
DOI : 10.1038/ni889

H. C. Whittle, N. Maine, J. Pilkington, M. Mendy, M. Fortuin et al., Long-term efficacy of continuing hepatitis B vaccination in infancy in two Gambian villages, The Lancet, vol.345, issue.8957, pp.1089-1092, 1995.
DOI : 10.1016/S0140-6736(95)90822-6

C. B. Wilson and E. K. Et-marcuse, Vaccine safety???vaccine benefits:science and the public's perception, Nature Reviews Immunology, vol.19, issue.2, pp.160-165, 2001.
DOI : 10.1038/35100585

L. Yang, H. Yang, K. Rideout, T. Cho, K. Joo et al., Engineered lentivector targeting of dendritic cells for in vivo immunization, Nature Biotechnology, vol.281, issue.3, pp.326-334, 2008.
DOI : 10.1038/nbt1390

A. Zandvoort and W. Et-timens, The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens, Clinical and Experimental Immunology, vol.26, issue.1, pp.4-11, 2002.
DOI : 10.1093/intimm/9.1.27

C. Zaph, J. Uzonna, S. M. Beverley, and P. Et-scott, Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites, Nature Medicine, vol.139, issue.10, pp.1104-1110, 2004.
DOI : 10.1016/0022-1759(94)90236-4

W. Zeng, E. M. Eriksson, A. Lew, and D. C. Et-jackson, Lipidation of intact proteins produces highly immunogenic vaccine candidates, Molecular Immunology, vol.48, issue.4
DOI : 10.1016/j.molimm.2010.10.003

J. Zhao, R. Voltan, B. Peng, A. Davis-warren, V. S. Kalyanaraman et al., Enhanced cellular immunity to SIV Gag following co-administration of adenoviruses encoding wild-type or mutant HIV Tat and SIV Gag, Virology, vol.342, issue.1, pp.1-12, 2005.
DOI : 10.1016/j.virol.2005.07.016

J. Zhou, K. R. Lottenbach, S. J. Barenkamp, and D. C. Et-reason, Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 6B, Infection and Immunity, vol.72, issue.6, pp.3505-3514, 2004.
DOI : 10.1128/IAI.72.6.3505-3514.2004

M. R. Zocchi, A. Poggi, and A. Et-rubartelli, The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells, AIDS, vol.11, issue.10, pp.1227-1235, 1997.
DOI : 10.1097/00002030-199710000-00005