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Fonctions physiologiques des aldoses réductases dans la glande surrénale

Abstract : The murine AKR1B7 protein belongs to the aldose reductase family. By its tissuerestricted expression and its tissue-specific hormonal regulation, it is a good model for the study of aldose reductase physiological functions. On the one hand, these doctoral work demonstrated ex vivo the role of murine and human aldose reductase prostaglandin F synthase activity in the adrenal gland. We highlighted a new feed-back loop between the cortex and the medulla using prostaglandin F2alpha as paracrine and/or autocrine signal. On the other hand, to achieve adrenal cortex specific inactivation of genes, we have developed the first transgenic mouse line showing specific Cre recombinase expression in this tissue. This line is a very powerful tool to create animal models of adrenal tumors.
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Submitted on : Tuesday, July 17, 2012 - 4:25:05 PM
Last modification on : Tuesday, April 20, 2021 - 11:54:02 AM
Long-term archiving on: : Friday, December 16, 2016 - 12:31:20 AM


  • HAL Id : tel-00718601, version 1



Sarah Lambert-Langlais. Fonctions physiologiques des aldoses réductases dans la glande surrénale. Génétique. Université Blaise Pascal - Clermont-Ferrand II; Université d'Auvergne - Clermont-Ferrand I, 2007. Français. ⟨NNT : 2007CLF21804⟩. ⟨tel-00718601⟩



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