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The skeletal muscle stem cell niche : defining hierarchies based upon the stem cell marker PW1 to identify therapeutic target cells

Abstract : Satellite cells are considered the major source of muscle progenitors, however, other populations with myogenic popential have been discovered. We have identified a new muscle-resident non-satellite cell population, termed PICs, which can differentiate into three different lineages, skeletal muscle, smooth muscle and fat. PICs rescue satellite cells from myostatin inhibition in vitro through follistatin release. When myostatin is inactivated in vivo, PICs number is markedly increased and mice display hypertrophied muscles. While recent studies have demonstrated that muscle regeneration cannot occur without satellite cells, we show that muscle regeneration is restored when mice have been previously treated with a myostatin inhibitor. We postulate that PICs have participated in muscle repair rescue, and thus constitute an interesting population to be targeted for pharmaceutical strategies aimed at improving skeletal muscle mass and function
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Submitted on : Wednesday, June 12, 2013 - 4:35:29 PM
Last modification on : Sunday, June 26, 2022 - 9:44:53 AM

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  • HAL Id : tel-00833422, version 1

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Alice Pannérec. The skeletal muscle stem cell niche : defining hierarchies based upon the stem cell marker PW1 to identify therapeutic target cells. Cellular Biology. Université Pierre et Marie Curie - Paris VI, 2012. English. ⟨NNT : 2012PAO66440⟩. ⟨tel-00833422⟩

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