G. Femur, . Fid, and . Bm, PMI from 0 to 24 h): Acetone 4.2?13.1 mg% Blood findings (PMI from 0 to 24 h), pp.10-45

M. Femur, G. /. Fid, and G. /. Bm, Amphetamine 0.1 µmol/100 g, Methamphetamine 1 µmol/100 g, Blood, vol.57, 1986.

?. Methamphetamine, . Gc, . Ms, and . Bm, Amphetamine + Methamphetamine 054 µmol/100 g [81] 2000 Blood findings (thermocoagulated blood): Amphetamine + Methamphetamine 1.66 µmol/100 g Bromisovalum Human BM pulverized and homogenized, LLE (ethyl ether) Case report, 1996.

L. Femur, . Ms, and . Bm, Bromisovalum 95.4 µg/g Blood findings: ? Bromisovalum Human BM ground into powder Case report: suspected ingestion of maximum 30 g of bromisovalum, 1997.

G. Femur, . Ms, R. Bm, and . Bm, Colchicine >600 ng/g Blood findings: ? Desipramine Rabbit BM homogenized in saline buffer (ultrasonication), LLE, lipids Experimental report: administration per os in a dose of 10?20 mg/kg daily for 5 days [24] 1990 Femur, tibia removal (hexane/ethanol/water) LC/DAD BM findings: Desipramine 0764 µg/g Blood findings: Desipramine 0.023?0.112 µg/ml BM findings: Morphine 135?1080 ng/mg at death, 102?1108 ng/mg after a 1-week period Buried, 0?592 ng/mg after a 2-week period buried Blood findings: Morphine 106?2350 ng/ml at death Morphine Mice BM homogenized (homogenizer), LLE (chloroforme/ Experimental report: single lethal dose by i.v. injection of 300 mg/kg 6 6-AM ? [54] 2007 isopropanol), BSTFA derivation GC/MS BM findings: Morphine 34?220 ng/mg at death, not detected after a 2-month period of conservation in bone; 6-AM 2.4?24 ng/mg at death, 0.3?6.3 ng/mg after a 2-month period of conservation in bone Blood findings: Morphine 10.8?88 ng/ml at death; 6-AM 6.7?57 ng/ml at death Experimental report: chronic administration of 10 to 20 mg/kg of 6-AM daily for 20 days BM findings: Morphine not detected, 6-AM not detected Blood findings: Morphine not detected, 6-AM not detected Nortriptyline Rabbit BM homogenized in saline solution (ultrasonication), Experimental report: administration per os in a dose of 20 mg/kg daily for 5 days [3] 1993 Femur, tibia LLE (hexane/alcohol), lipids removal (hexane, Bromisovalum in left femur 139 right femur 36.4 µg/g Blood findings: ? Colchicine Human BM homogenized in phosphate buffer (homogenizer) Case report LC/DAD BM findings term of ratio blood/BM Pentobarbital Rabbit BM homogenized (ultrasonication), LLE (toluene) Experimental report: administration per os of a non lethal dosage, pp.745-748, 1985.

G. Femur, . Fid, and . Bm, Pentobarbital 2.29?3.70 mg% Blood findings: Pentobarbital 2.26?3.20 mg% Experimental report: administration per os of a lethal dosage (234?273 mg/kg) BM findings (PMI from 6 to 12 h): 4.3?6.68 mg% Blood findings (PMI 6 h): 4.66?5.69 mg% Triazolam Human Digestion at basic pH under heat, LLE (tert-butyl methyl ether) Case report, 1997.

G. Femur and . Bm, Triazolam for victim 1: 0.36 ng/g, victim 2: 0

. Bm-bone-marrow, CEDIA cloned enzyme donor immunoassay, DAD diode array detector, ECD electron capture detector, ELISA enzyme-linked immunosorbent assay, FID flame ionization detector, FPIA fluorescence polarization immunoassay, GC gas chromatography, i.p. intraperitoneal, i.v. intravenous, LC liquid chromatography, LLE liquid?liquid extraction, MS mass spectrometry, NICI negative ion chemical ionization, PMI postmortem interval, RIA radioimmunoassay, SPE solid phase extraction, TFA trifluoroacetic acid, TMSA trimethylsilylacetamide, ?not available Int J Legal Med Drugs detected Species Sample Pretreatment Reference and year Sampling location Analytical assays References 6 References, CNS Drugs, vol.24, pp.611-620, 2010.

K. P. Marshall, Z. Georgievskava, I. Georgievsky, . Res, and . Social, Social reactions to Valium and Prozac: A cultural lag perspective of drug diffusion and adoption, Research in Social and Administrative Pharmacy, vol.5, issue.2, pp.94-107, 2009.
DOI : 10.1016/j.sapharm.2008.06.005

S. A. Hollingworth and D. J. Siskind, Anxiolytic, hypnotic and sedative medication use in Australia, Pharmacoepidemiology and Drug Safety, vol.8, issue.24, pp.280-288, 2010.
DOI : 10.1002/pds.1899

R. Mandrioli, L. Mercolini, and M. A. Raggi, Metabolism of Benzodiazepine and Non-Benzodiazepine Anxiolytic-Hypnotic Drugs: an Analytical Point of View, Current Drug Metabolism, vol.11, issue.9, pp.815-829, 2010.
DOI : 10.2174/138920010794328887

B. Jonasson and T. Saldeen, Citalopram in fatal poisoning cases, Forensic Science International, vol.126, issue.1, pp.1-6, 2002.
DOI : 10.1016/S0379-0738(01)00632-6

G. Skopp, Preanalytic aspects in postmortem toxicology, Forensic Science International, vol.142, issue.2-3, pp.75-100, 2004.
DOI : 10.1016/j.forsciint.2004.02.012

N. Unceta, M. A. Goicolea, and R. J. Barrio, Analytical procedures for the determination of the selective serotonin reuptake inhibitor antidepressant citalopram and its metabolites, Biomedical Chromatography, vol.22, issue.1-2, pp.238-257, 2011.
DOI : 10.1002/bmc.1542

X. Liu, K. Van-natta, H. Yeo, O. Vilenski, P. E. Weller et al., Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid, Drug Metabolism and Disposition, vol.37, issue.4, pp.787-793, 2009.
DOI : 10.1124/dmd.108.024125

N. S. Wang and B. Lemmer, Determination of citalopram in plasma and brain tissue of the rat by high-performance liquid chromatography with ultraviolet detection, Journal of Chromatography B: Biomedical Sciences and Applications, vol.488, issue.2, pp.492-497, 1989.
DOI : 10.1016/S0378-4347(00)82975-8

]. K. Fu, R. J. Konrad, R. W. Hardy, R. M. Brissie, and C. A. Robinson, An Unusual Multiple Drug Intoxication Case Involving Citalopram, Journal of Analytical Toxicology, vol.24, issue.7, pp.648-650, 2000.
DOI : 10.1093/jat/24.7.648

]. D. Luchini, G. Morabito, and F. Centini, Case Report of a Fatal Intoxication by Citalopram, The American Journal of Forensic Medicine and Pathology, vol.26, issue.4, pp.352-354, 2005.
DOI : 10.1097/01.paf.0000188276.33030.dd

]. L. Mercolini, R. Mandrioli, C. Iannello, F. Matrisciano, F. Nicoletti et al., Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE, Talanta, vol.80, issue.1, pp.279-285, 2009.
DOI : 10.1016/j.talanta.2009.06.074

]. K. Heinig and F. Bucheli, Application of column-switching liquid chromatography-tandem mass spectrometry for the determination of pharmaceutical compounds in tissue samples, Journal of Chromatography B, vol.769, issue.1, pp.9-26, 2002.
DOI : 10.1016/S1570-0232(01)00600-6

]. K. Kudo, T. Nagata, K. Kimura, T. Imamura, and M. Noda, Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry, Journal of Chromatography B: Biomedical Sciences and Applications, vol.431, pp.353-359, 1988.
DOI : 10.1016/S0378-4347(00)83103-5

X. X. Zhang, K. Kudo, T. Imamura, N. Jitsufuchi, and T. Nagata, Sensitive determination of bromazepam in human tissues using capillary gas chromatography-mass spectrometry, Journal of Chromatography B: Biomedical Sciences and Applications, vol.677, issue.1, pp.111-116, 1996.
DOI : 10.1016/0378-4347(95)00427-0

]. F. Moriya and Y. Hashimoto, Tissue distribution of nitrazepam and 7-aminonitrazepam in a case of nitrazepam intoxication, Forensic Science International, vol.131, issue.2-3, pp.108-112, 2003.
DOI : 10.1016/S0379-0738(02)00421-8

A. J. Jenkins, B. Levine, J. L. Locke, and J. E. Smialek, A Fatality Due To Alprazolam Intoxication, Journal of Analytical Toxicology, vol.21, issue.3, pp.218-220, 1997.
DOI : 10.1093/jat/21.3.218

]. F. Moriya and Y. Hashimoto, A case of fatal triazolam overdose, Legal Medicine, vol.5, issue.1, pp.91-95, 2003.
DOI : 10.1016/S1344-6223(02)00074-3

]. K. Kudo, T. Nagata, T. Imamura, S. Kage, and Y. Hida, Forensic analysis of triazolam in human tissues using capillary gas chromatography, International Journal of Legal Medicine, vol.22, issue.2, pp.67-69, 1991.
DOI : 10.1007/BF01626033

]. B. Levine, A. Grieshaber, J. Pestaner, K. A. Moore, and J. E. Smialek, Distribution of Triazolam and ??-Hydroxytriazolam in a Fatal Intoxication Case, Journal of Analytical Toxicology, vol.26, issue.1, pp.52-54, 2002.
DOI : 10.1093/jat/26.1.52

]. S. Bjorkman, A. Fyge, and Z. Qi, Determination of the Steady State Tissue Distribution of Midazolam in the Rat, Journal of Pharmaceutical Sciences, vol.85, issue.8, pp.887-889, 1996.
DOI : 10.1021/js960113+

]. F. Musshoff, S. Padosch, S. Steinborn, and B. Madea, Fatal blood and tissue concentrations of more than 200 drugs, Forensic Science International, vol.142, issue.2-3, pp.161-210, 2004.
DOI : 10.1016/j.forsciint.2004.02.017

G. Mckay and K. J. , [33] Bioanalytical method validation, gtfch.org/cms/images/stories/Updated_TIAFT_list_202005.pdf, 2011.

J. Segura, R. Ventura, and C. Jurado, Derivatization procedures for gas chromatographic???mass spectrometric determination of xenobiotics in biological samples, with special attention to drugs of abuse and doping agents, Journal of Chromatography B: Biomedical Sciences and Applications, vol.713, issue.1, pp.61-90, 1998.
DOI : 10.1016/S0378-4347(98)00089-9

]. C. Pistos, I. Panderi, and J. Atta-politou, Liquid chromatography???positive ion electrospray mass spectrometry method for the quantification of citalopram in human plasma, Journal of Chromatography B, vol.810, issue.2, pp.235-244, 2004.
DOI : 10.1016/S1570-0232(04)00605-1

J. Wang, X. Shen, J. Fenyk-melody, J. V. Pivnichny, and X. Tong, Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid, Rapid Communications in Mass Spectrometry, vol.14, issue.6, pp.519-525, 2003.
DOI : 10.1002/rcm.942

F. Mitewa and . Sci, [Epub ahead of print]. [41] A. El Mahjoub, C. Staub, Int. J. Pharm. Biomed. Anal, vol.23, pp.1057-1063, 2000.

F. T. Peters, Stability of analytes in biosamples???an important issue in clinical and forensic toxicology?, Analytical and Bioanalytical Chemistry, vol.28, issue.7, pp.1505-1519, 2007.
DOI : 10.1007/s00216-007-1267-2

]. T. Takatori, S. Tomii, K. Terazawa, M. Nagao, M. Kanamori et al., A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue, International Journal of Legal Medicine, vol.74, issue.4, pp.185-188, 1991.
DOI : 10.1007/BF01369803

J. H. Watterson and J. E. Botman, Detection of Acute Diazepam Exposure in Bone and Marrow: Influence of Tissue Type and the Dose-Death Interval on Sensitivity of Detection by ELISA with Liquid Chromatography Tandem Mass Spectrometry Confirmation, Journal of Forensic Sciences, vol.10, issue.2, pp.708-714, 2009.
DOI : 10.1111/j.1556-4029.2009.00998.x

L. M. Mcintyre, C. V. King, M. Boratto, and O. H. Drummer, Post-Mortem Drug Analyses in Bone and Bone Marrow, Therapeutic Drug Monitoring, vol.22, issue.1, pp.79-83, 2000.
DOI : 10.1097/00007691-200002000-00017

]. N. Cartiser, F. Bevalot, L. Fanton, Y. Gaillard, and J. Guitton, State-of-the-art of bone marrow analysis in forensic toxicology: a review, International Journal of Legal Medicine, vol.54, issue.2, 2010.
DOI : 10.1007/s00414-010-0525-6

J. Watterson, Challenges in forensic toxicology of skeletonised human remains, The Analyst, vol.123, issue.9, pp.961-965, 2006.
DOI : 10.1039/b609130j

C. L. Winek and T. Jones, Blood Versus bone marrow ethanol concentrations in rabbits and humans, Forensic Science International, vol.16, issue.2, pp.101-109, 1980.
DOI : 10.1016/0379-0738(80)90162-0

L. M. Mcintyre, C. V. King, M. Boratto, and O. H. Drummer, Post-Mortem Drug Analyses in Bone and Bone Marrow, Therapeutic Drug Monitoring, vol.22, issue.1, pp.79-83, 2000.
DOI : 10.1097/00007691-200002000-00017

H. Maeda, S. Oritani, K. Nagai, T. Tanaka, and N. Tanaka, Detection of Bromisovalum from the Bone Marrow of Skeletonized Human Remains: A Case Report with a Comparison between Gas Chromatography/Mass Spectrometry (GC/MS) and High-Performance Liquid Chromatography/Mass Spectrometry (LC/MS), Medicine, Science and the Law, vol.22, issue.3, pp.37-248, 1997.
DOI : 10.1177/002580249703700310

G. Thelander, A. K. Jonsson, M. Personne, G. S. Forsberg, K. M. Lundqvist et al., Caffeine fatalities ??? Do sales restrictions prevent intentional intoxications?, Clinical Toxicology, vol.51, issue.4, pp.354-358
DOI : 10.1002/j.1552-4604.1997.tb04356.x

C. J. Reissig, E. C. Strain, and R. R. Griffiths, Caffeinated energy drinks???A growing problem, Drug and Alcohol Dependence, vol.99, issue.1-3, pp.1-10, 2009.
DOI : 10.1016/j.drugalcdep.2008.08.001

V. P. Shah, K. K. Midha, J. W. Findlay, H. M. Hill, J. D. Hulse et al., Bioanalytical method validation?a revisit with a decade of progress, Pharmaceutical Research, vol.17, issue.12, pp.1551-1557, 2000.
DOI : 10.1023/A:1007669411738

D. Carli, M. Honorat, S. Cohen, M. Megherbi, B. Vignal et al., Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS, Journal of Chromatography B, vol.877, issue.27, pp.2937-2944, 2009.
DOI : 10.1016/j.jchromb.2009.07.004

R. J. Flanagan, G. Connally, and J. M. Evans, Analytical Toxicology, Toxicological Reviews, vol.17, issue.1, pp.63-71, 2005.
DOI : 10.2165/00139709-200524010-00005

G. Skopp, Preanalytic aspects in postmortem toxicology, Forensic Science International, vol.142, issue.2-3, pp.75-100, 2004.
DOI : 10.1016/j.forsciint.2004.02.012

M. Dalpe-scott, M. Degouffe, D. Garbutt, and M. Drost, A comparison of drug con-centrations in postmortem cardiac and peripheral blood in 320 cases, Can. Soc. For. Sci. J, pp.28-113, 1995.

J. S. Blebea, M. Houseni, D. A. Torigian, C. Fan, A. Mavi et al., Structural and Functional Imaging of Normal Bone Marrow and Evaluation of Its Age-Related Changes, Seminars in Nuclear Medicine, vol.37, issue.3, pp.37-185, 2007.
DOI : 10.1053/j.semnuclmed.2007.01.002

S. C. Kim, B. R. Krynyckyi, J. Machac, and C. K. Kim, Patterns of Red Marrow in the Adult Femur, Clinical Nuclear Medicine, vol.31, issue.12, pp.31-739, 2006.
DOI : 10.1097/01.rlu.0000246647.71244.3d

H. E. Daldrup-link, T. Henning, and T. M. Link, MR imaging of therapy-induced changes of bone marrow, European Radiology, vol.27, issue.3, pp.743-761, 2007.
DOI : 10.1007/s00330-006-0404-1

S. Hwang and D. M. Panicek, Magnetic resonance imaging of bone marrow in oncology, Part 2, Skeletal Radiology, vol.20, issue.11, pp.1017-1027, 2007.
DOI : 10.1007/s00256-007-0308-4

S. Hwang and D. M. Panicek, Magnetic resonance imaging of bone marrow in oncology, Part 1, Skeletal Radiology, vol.23, issue.10, pp.913-920, 2007.
DOI : 10.1007/s00256-007-0309-3

B. R. Rosen, D. M. Fleming, D. C. Kushner, K. S. Zaner, R. B. Buxton et al., Hematologic bone marrow disorders: quantitative chemical shift MR imaging., Radiology, vol.169, issue.3, pp.799-804, 1988.
DOI : 10.1148/radiology.169.3.3187003

C. L. Winek and D. Susa, Blood versus bone marrow methanol concentrations in rabbits, Forensic Science International, vol.19, issue.2, pp.165-175, 1982.
DOI : 10.1016/0379-0738(82)90042-1

C. L. Winek and F. M. Esposito, Comparative study of ethanol levels in blood versus bone marrow, vitreous humor, bile and urine, Forensic Science International, vol.17, issue.1, pp.27-36, 1981.
DOI : 10.1016/0379-0738(81)90185-7

C. L. Winek and J. K. Janssen, Blood versus bone marrow isopropanol concentrations in rabbits, Forensic Science International, vol.20, issue.1, pp.11-20, 1982.
DOI : 10.1016/0379-0738(82)90100-1

F. Bé-valot, L. Dujourdy, L. Fanton, N. Cartiser, L. Magné et al., Statistic interpretation of meprobamate concentrations in bone marrow, vitreous and bile, Proceedings of the International Meeting of the International Association of Forensic Toxicologists, p.431, 2008.

R. Akcan, A. Hilal, N. Daglioglu, N. Cekin, and M. K. Gulmen, Determination of pesticides in postmortem blood and bone marrow of pesticide treated rabbits, Forensic Science International, vol.189, issue.1-3, pp.189-82, 2009.
DOI : 10.1016/j.forsciint.2009.04.017

C. L. Winek, M. Pluskota, and W. W. Wahba, Plasma versus bone marrow flurazepam concentration in rabbits, Forensic Science International, vol.19, issue.2, pp.155-163, 1982.
DOI : 10.1016/0379-0738(82)90041-X

T. Takatori, S. Tomii, K. Terazawa, M. Nagao, M. Kanamori et al., A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue, International Journal of Legal Medicine, vol.74, issue.4, pp.185-188, 1991.
DOI : 10.1007/BF01369803

C. L. Winek, S. E. Westwood, and W. W. Wahba, Plasma versus bone marrow desipramine: A comparative study, Forensic Science International, vol.48, issue.1, pp.48-49, 1990.
DOI : 10.1016/0379-0738(90)90271-Y

C. L. Winek, E. M. Morris, and W. W. Wahba, The Use of Bone Marrow in the Study of Postmortem Redistribution of Nortriptyline, Journal of Analytical Toxicology, vol.17, issue.2, pp.93-98, 1993.
DOI : 10.1093/jat/17.2.93

H. Schloegl, T. Rost, W. Schmidt, F. M. Wurst, and W. Weinmann, Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death, Forensic Science International, vol.156, issue.2-3, pp.156-213, 2006.
DOI : 10.1016/j.forsciint.2005.03.024

H. Maeda, B. L. Zhu, T. Ishikawa, S. Oritani, T. Michiue et al., Evaluation of post-mortem ethanol concentrations in pericardial fluid and bone marrow aspirate, Forensic Science International, vol.161, issue.2-3, pp.161-141, 2006.
DOI : 10.1016/j.forsciint.2006.01.016

R. 1. Frank, W. Llewellyn, and B. , A Time Course Study on STR Profiles Derived from Human Bone, Muscle and Bone Marrow, Journal of Forensic Sciences, vol.44, issue.4, pp.778-82, 1999.
DOI : 10.1520/JFS14551J

K. Gruspier and M. Pollanen, Limbs found in water: investigation using anthropological analysis and the diatom test, Forensic Science International, vol.112, issue.1, pp.1-9, 2000.
DOI : 10.1016/S0379-0738(99)00231-5

M. Pollanen, The Diagnostic Value of the Diatom Test for Drowning, II. Validity: Analysis of Diatoms in Bone Marrow and Drowning Medium, Journal of Forensic Sciences, vol.42, issue.2, 1997.
DOI : 10.1520/JFS14112J

M. Pollanen, C. Cheung, and D. Chiasson, The Diagnostic Value of the Diatom Test for Drowning, I. Utility: A Retrospective Analysis of 771 Cases of Drowning in Ontario, Canada, Journal of Forensic Sciences, vol.42, issue.2, pp.281-286, 1997.
DOI : 10.1520/JFS14111J

P. Roll, A. Beham, and C. Beham-schmid, Post-mortem histopathological investigations of the bone marrow in forensic medicine: An important issue for both the forensic and clinical pathologist, Forensic Science International, vol.186, issue.1-3, 2009.
DOI : 10.1016/j.forsciint.2008.12.005

K. Sakai, A. Takatsu, A. Shigeta, S. Abe, M. Ikegami et al., Sudden death due to undiagnosed acute promyelocytic leukemia: a case report, International Journal of Legal Medicine, vol.83, issue.Suppl 2, 2007.
DOI : 10.1007/s00414-006-0106-x

A. Umezawa, T. Yamada, Y. Ogawa, S. Kuramochi, and Y. Watanabe, Postmortem diagnosis of acute megakaryocytic leukemia. Usefulness of immunohistochemistry and tissue hemogram, Acta Pathol Jpn, vol.40, issue.9, pp.693-701, 1990.

L. Mcintyre, C. King, M. Boratto, and O. Drummer, Post-Mortem Drug Analyses in Bone and Bone Marrow, Therapeutic Drug Monitoring, vol.22, issue.1, pp.79-83, 2000.
DOI : 10.1097/00007691-200002000-00017

M. Rochdi, A. Sabouraud, F. Baud, C. Bismuth, and J. Scherrmann, Toxicokinetics of Colchicine in Humans: Analysis of Tissue, Plasma and Urine Data in Ten Cases, Human & Experimental Toxicology, vol.11, issue.6, pp.510-516, 1992.
DOI : 10.1177/096032719201100612

N. Raikos, H. Tsoukali, and S. Njau, Determination of opiates in postmortem bone and bone marrow, Forensic Science International, vol.123, issue.2-3, pp.140-141, 2001.
DOI : 10.1016/S0379-0738(01)00529-1

T. Bal, R. Hewitt, A. Hiscutt, and J. B. , Analysis of bone marrow and decomposed body tissue for the presence of paracetamol and dextropropoxyphene, Journal of the Forensic Science Society, vol.29, issue.3, pp.219-242, 1989.
DOI : 10.1016/S0015-7368(89)73251-5

K. Kudo, H. Sugie, N. Syoui, K. Kurihara, N. Jitsufuchi et al., Detection of triazolam in skeletal remains buried for 4 years, International Journal of Legal Medicine, vol.110, issue.5, pp.281-284, 1997.
DOI : 10.1007/s004140050086

H. Maeda, S. Oritani, K. Nagai, T. Tanaka, and N. Tanaka, Detection of Bromisovalum from the Bone Marrow of Skeletonized Human Remains: A Case Report with a Comparison between Gas Chromatography/Mass Spectrometry (GC/MS) and High-Performance Liquid Chromatography/Mass Spectrometry (LC/MS), Medicine, Science and the Law, vol.22, issue.3, pp.248-53, 1997.
DOI : 10.1177/002580249703700310

T. Noguchi, G. Nakamura, and E. Griesemer, Drug Analyses of Skeletonizing Remains, Journal of Forensic Sciences, vol.23, issue.3, pp.490-492, 1978.
DOI : 10.1520/JFS10695J

T. Kojima, I. Okamoto, T. Miyazaki, F. Chikasue, M. Yashiki et al., Detection of methamphetamine and amphetamine in a skeletonized body buried for 5 years, Forensic Science International, vol.31, issue.2, pp.93-102, 1986.
DOI : 10.1016/0379-0738(86)90193-3

C. Winek and F. Esposito, Comparative study of ethanol levels in blood versus bone marrow, vitreous humor, bile and urine, Forensic Science International, vol.17, issue.1, pp.27-36, 1981.
DOI : 10.1016/0379-0738(81)90185-7

C. Winek and T. Jones, Blood Versus bone marrow ethanol concentrations in rabbits and humans, Forensic Science International, vol.16, issue.2, pp.101-110, 1980.
DOI : 10.1016/0379-0738(80)90162-0

H. Maeda, B. Zhu, T. Ishikawa, S. Oritani, T. Michiue et al., Evaluation of postmortem ethanol concentrations in pericardial fluid and bone marrow aspirate, Forensic Sci Int, vol.161, pp.2-3141, 2006.

H. Schloegl, T. Rost, W. Schmidt, F. Wurst, and W. Weinmann, Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death, Forensic Science International, vol.156, issue.2-3, pp.2-3213, 2006.
DOI : 10.1016/j.forsciint.2005.03.024

F. Bévalot, L. Dujourdy, L. Fanton, N. Cartiser, L. Magné et al., Statistic interpretation of meprobamate concentrations in bone marrow, vitreous and bile. Proceedings of International Meeting of The International Association of Forensic Toxicologists, 2008.

C. Winek and D. Susa, Blood versus bone marrow methanol concentrations in rabbits, Forensic Science International, vol.19, issue.2, pp.165-75, 1982.
DOI : 10.1016/0379-0738(82)90042-1

C. Winek and J. Janssen, Blood versus bone marrow isopropanol concentrations in rabbits, Forensic Science International, vol.20, issue.1, pp.11-20, 1982.
DOI : 10.1016/0379-0738(82)90100-1

C. Winek, A. Costantino, W. Wahba, and W. Collom, Blood versus bone marrow pentobarbital concentrations, Forensic Science International, vol.27, issue.1, pp.15-24, 1985.
DOI : 10.1016/0379-0738(85)90100-8

C. Winek, M. Pluskota, and W. Wahba, Plasma versus bone marrow flurazepam concentration in rabbits, Forensic Science International, vol.19, issue.2, pp.155-63, 1982.
DOI : 10.1016/0379-0738(82)90041-X

C. Winek, E. Morris, and W. Wahba, The Use of Bone Marrow in the Study of Postmortem Redistribution of Nortriptyline, Journal of Analytical Toxicology, vol.17, issue.2, pp.93-101, 1993.
DOI : 10.1093/jat/17.2.93

C. Winek, S. Westwood, and W. Wahba, Plasma versus bone marrow desipramine: A comparative study, Forensic Science International, vol.48, issue.1, pp.49-57, 1990.
DOI : 10.1016/0379-0738(90)90271-Y

C. Winek, W. Cibulas, J. Wahba, and W. , A comparative study of ethchlorvynol levels in blood versus bone marrow, Forensic Science International, vol.17, issue.3, pp.197-202, 1981.
DOI : 10.1016/0379-0738(81)90167-5

S. Cengiz, O. Ulukan, I. Ates, and H. Tugcu, Determination of morphine in postmortem rabbit bone marrow and comparison with blood morphine concentrations, Forensic Science International, vol.156, issue.2-3, pp.91-95, 2006.
DOI : 10.1016/j.forsciint.2004.12.017

V. Shah, K. Midha, J. Findlay, H. Hill, J. Hulse et al., Bioanalytical method validation--a revisit with a decade of progress, Pharm Res, 2000.

C. Vinson, Modèles pharmacocinétiques basés sur la physiologie et analyse d'incertitude: Application de l'analyse de sensibilité et l'analyse de Monte Carlo à l'étude de la variabilité pharmacocinétique de molécules en développement, 1 -Institut des Sciences Pharmaceutiques et Biologiques, 2004.

M. Rowland, L. Balant, and C. Peck, Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science, Annual Review of Pharmacology and Toxicology, vol.51, issue.1, pp.56-67, 2002.
DOI : 10.1146/annurev-pharmtox-010510-100540

Z. Desta, X. Zhao, J. Shin, and D. Flockhart, Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism, Clinical Pharmacokinetics, vol.32, issue.4, pp.913-58, 2002.
DOI : 10.2165/00003088-200241120-00002

D. Murdoch and S. Keam, Escitalopram, Drugs, vol.30, issue.6, pp.2379-404, 2005.
DOI : 10.2165/00003495-200565160-00013

N. Rao, The Clinical Pharmacokinetics of Escitalopram, Clinical Pharmacokinetics, vol.305, issue.1, pp.281-90, 2007.
DOI : 10.2165/00003088-200746040-00002

J. Riss, J. Cloyd, J. Gates, and S. Collins, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics, Acta Neurologica Scandinavica, vol.241, issue.2, 2008.
DOI : 10.1111/j.1600-0404.2008.01004.x

E. Tanaka, Clinically significant pharmacokinetic drug interactions with benzodiazepines, Journal of Clinical Pharmacy and Therapeutics, vol.13, issue.5, pp.347-55, 1999.
DOI : 10.1016/S0140-6736(80)90364-5

J. Kwon and K. Armbrust, Aqueous Solubility, n-Octanol???Water Partition Coefficient, and Sorption of Five Selective Serotonin Reuptake Inhibitors to Sediments and Soils, Bulletin of Environmental Contamination and Toxicology, vol.56, issue.2;18, pp.128-163, 2008.
DOI : 10.1007/s00128-008-9401-1

A. Moffat, Clarke's Isolation and identification of drugs in pharmaceuticals, body fluids, and post-mortem material, 1986.

R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 44. D'argenio DZ, Schumitzky A. Adapt II User's Guide, 2002.

. Pharmacokinetic, Pharmacodynamic Systems Analysis Software. Los Angeles: Biomedical Simulations Resource, 1997.

D. Levitt, The pharmacokinetics of the interstitial space in humans, BMC Clinical Pharmacology, vol.51, issue.1, p.3, 2003.
DOI : 10.1161/01.RES.51.3.305

B. Davies and T. Morris, Physiological parameters in laboratory animals and humans, Pharmaceutical Research, vol.10, issue.7, pp.1093-1098, 1993.
DOI : 10.1023/A:1018943613122

R. Brown, M. Delp, S. Lindstedt, L. Rhomberg, and R. Beliles, Physiological Parameter Values for Physiologically Based Pharmacokinetic Models, Toxicology and Industrial Health, vol.191, issue.1, 1997.
DOI : 10.1177/074823379701300401

L. Sweeney, C. Kirman, S. Gannon, K. Thrall, M. Gargas et al., Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans, Inhalation Toxicology, vol.57, issue.3, pp.552-82, 2009.
DOI : 10.1006/taap.2002.9432

G. West, J. Brown, and B. Enquist, The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms, Science, vol.284, issue.5420, pp.1677-1686, 1999.
DOI : 10.1126/science.284.5420.1677

G. West, J. Brown, and B. Enquist, A General Model for the Origin of Allometric Scaling Laws in Biology, Science, vol.276, issue.5309, pp.122-128, 1997.
DOI : 10.1126/science.276.5309.122

H. Clewell and B. Jarnot, Incorporation of Pharmacokinetics in Noncancer Risk Assessment: Example with Chloropentafluorobenzene, Risk Analysis, vol.7, issue.105, pp.265-76, 1994.
DOI : 10.1016/0378-4274(93)90123-F

K. Bezchlibnyk-butler, I. Aleksic, and S. Kennedy, Citalopram--a review of pharmacological and clinical effects, J Psychiatry Neurosci, vol.25, issue.3, pp.241-54, 2000.

M. Jack and W. Colburn, Pharmacokinetic Model for Diazepam and its Major Metabolite Desmethyldiazepam Following Diazepam Administration, Journal of Pharmaceutical Sciences, vol.72, issue.11, 1983.
DOI : 10.1002/jps.2600721120

S. Kaplan, M. Jack, K. Alexander, and R. Weinfeld, Pharmacokinetic Profile of Diazepam in Man following Single Intravenous and Oral and Chronic Oral Administrations, Journal of Pharmaceutical Sciences, vol.62, issue.11, pp.1789-96, 1973.
DOI : 10.1002/jps.2600621111

M. Mandelli, G. Tognoni, and S. Garattini, Clinical Pharmacokinetics of Diazepam, Clinical Pharmacokinetics, vol.3, issue.1, pp.72-91, 1978.
DOI : 10.2165/00003088-197803010-00005

P. Kragh-sorensen, K. Overo, O. Petersen, K. Jensen, and W. Parnas, The Kinetics of Citalopram: Single and Multiple Dose Studies in Man, Acta Pharmacologica et Toxicologica, vol.21, issue.Suppl. 1, 1981.
DOI : 10.1111/j.1600-0773.1981.tb01587.x

P. Joffe, F. Larsen, V. Pedersen, H. Ring-larsen, T. Aaes-jorgensen et al., Single-dose pharmacokinetics of citalopram in patients with moderate renal insufficiency or hepatic cirrhosis compared with healthy subjects, European Journal of Clinical Pharmacology, vol.54, issue.3, pp.237-279, 1998.
DOI : 10.1007/s002280050452

F. Boer, Drug handling by the lungs, British Journal of Anaesthesia, vol.91, issue.1, pp.50-60, 2003.
DOI : 10.1093/bja/aeg117

F. Kugelberg, M. Kingback, B. Carlsson, and H. Druid, Early-Phase Postmortem Redistribution of the Enantiomers of Citalopram and Its Demethylated Metabolites in Rats, Journal of Analytical Toxicology, vol.29, issue.4
DOI : 10.1093/jat/29.4.223

E. Horak and A. Jenkins, Postmortem Tissue Distribution of Olanzapine and Citalopram in a Drug Intoxication, Journal of Forensic Sciences, vol.50, issue.3, pp.679-81, 2005.
DOI : 10.1520/JFS2004067

D. Luchini, G. Morabito, and F. Centini, Case Report of a Fatal Intoxication by Citalopram, The American Journal of Forensic Medicine and Pathology, vol.26, issue.4, pp.352-356, 2005.
DOI : 10.1097/01.paf.0000188276.33030.dd

B. Levine, X. Zhang, J. Smialek, G. Kunsman, and M. Frontz, Citalopram Distribution in Postmortem Cases, Journal of Analytical Toxicology, vol.25, issue.7, pp.641-645, 2001.
DOI : 10.1093/jat/25.7.641

N. Anastos, I. Mcintyre, M. Lynch, and O. Drummer, Postmortem Concentrations of Citalopram, Journal of Forensic Sciences, vol.47, issue.4, pp.882-886, 2002.
DOI : 10.1520/JFS15458J

K. Fu, R. Konrad, R. Hardy, R. Brissie, and C. Robinson, An Unusual Multiple Drug Intoxication Case Involving Citalopram, Journal of Analytical Toxicology, vol.24, issue.7, pp.648-50, 2000.
DOI : 10.1093/jat/24.7.648

N. Cartiser, F. Bevalot, L. Fanton, Y. Gaillard, and J. Guitton, State-of-the-art of bone marrow analysis in forensic toxicology: a review, International Journal of Legal Medicine, vol.54, issue.2, 2009.
DOI : 10.1007/s00414-010-0525-6

J. Crifasi, M. Bruder, C. Long, and K. Janssen, Performance Evaluation of Thermal Desorption System (TDS) for Detection of Basic Drugs in Forensic Samples by GC-MS, Journal of Analytical Toxicology, vol.30, issue.8, pp.581-92, 2006.
DOI : 10.1093/jat/30.8.581

X. Liu, K. Van-natta, H. Yeo, O. Vilenski, P. Weller et al., Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid, Drug Metabolism and Disposition, vol.37, issue.4, 2009.
DOI : 10.1124/dmd.108.024125

N. Unceta, A. Ugarte, A. Sanchez, A. Gomez-caballero, M. Goicolea et al., Development of a stir bar sorptive extraction based HPLC-FLD method for the quantification of serotonin reuptake inhibitors in plasma

N. Wang and B. Lemmer, Determination of citalopram in plasma and brain tissue of the rat by high-performance liquid chromatography with ultraviolet detection, Journal of Chromatography B: Biomedical Sciences and Applications, vol.488, issue.2, pp.492-499, 1989.
DOI : 10.1016/S0378-4347(00)82975-8

S. Wille, D. Letter, E. Piette, M. Van-overschelde, L. et al., Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography???mass spectrometry, International Journal of Legal Medicine, vol.56, issue.6, 2009.
DOI : 10.1007/s00414-008-0287-6

K. Kudo, T. Nagata, K. Kimura, T. Imamura, and M. Noda, Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry, Journal of Chromatography B: Biomedical Sciences and Applications, vol.431, issue.2, pp.353-362, 1988.
DOI : 10.1016/S0378-4347(00)83103-5

H. Shiota, M. Nakashima, H. Terazono, H. Sasaki, K. Nishida et al., Postmortem changes in tissue concentrations of triazolam and diazepam in rats, Legal Medicine, vol.6, issue.4, pp.224-256, 2004.
DOI : 10.1016/j.legalmed.2004.05.006

A. Jenkins, B. Levine, J. Locke, and J. Smialek, A Fatality Due To Alprazolam Intoxication, Journal of Analytical Toxicology, vol.21, issue.3
DOI : 10.1093/jat/21.3.218

F. Moriya and Y. Hashimoto, Tissue distribution of nitrazepam and 7-aminonitrazepam in a case of nitrazepam intoxication, Forensic Science International, vol.131, issue.2-3, pp.108-120, 2003.
DOI : 10.1016/S0379-0738(02)00421-8

F. Moriya and Y. Hashimoto, A case of fatal triazolam overdose, Legal Medicine, vol.5, 2003.
DOI : 10.1016/S1344-6223(02)00074-3

T. Takatori, S. Tomii, K. Terazawa, M. Nagao, M. Kanamori et al., A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue, International Journal of Legal Medicine, vol.74, issue.4, pp.185-193, 1991.
DOI : 10.1007/BF01369803

X. Zhang, K. Kudo, T. Imamura, N. Jitsufuchi, and T. Nagata, Sensitive determination of bromazepam in human tissues using capillary gas chromatography-mass spectrometry, Journal of Chromatography B: Biomedical Sciences and Applications, vol.677, issue.1, pp.111-117, 1996.
DOI : 10.1016/0378-4347(95)00427-0