O. Garra and A. , Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets, Immunity, vol.8, issue.3, pp.275-283, 1998.
DOI : 10.1016/S1074-7613(00)80533-6

W. Ouyang, J. Kolls, and Y. Zheng, The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation, Immunity, vol.28, issue.4, pp.454-467, 2008.
DOI : 10.1016/j.immuni.2008.03.004

T. Korn, E. Bettelli, M. Oukka, and V. Kuchroo, IL-17 and Th17 Cells, Annual Review of Immunology, vol.27, issue.1, pp.485-517, 2009.
DOI : 10.1146/annurev.immunol.021908.132710

E. Volpe, N. Servant, and R. Zollinger, A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human

R. Acosta-rodriguez, E. Rivino, L. Geginat, J. Jarrossay, D. Gattorno et al., Surface phenotype and antigenic specificity of human interleukin 17???producing T helper memory cells, Nature Immunology, vol.179, issue.6, pp.639-646, 2007.
DOI : 10.1038/ni1467

T. Asselah, I. Bieche, A. Sabbagh, P. Bedossa, and R. Moreau, Gene expression and hepatitis C virus infection, Gut, vol.58, issue.6, pp.846-858, 2009.
DOI : 10.1136/gut.2008.166348

R. Axtell, B. De-jong, K. Boniface, L. Van-der-voort, and R. Bhat, T helper type 1 and 17 cells determine efficacy of interferon-?? in multiple sclerosis and experimental encephalomyelitis, Nature Medicine, vol.95, issue.4, pp.406-412
DOI : 10.1038/nm.2110

L. Azzoni, A. Foulkes, E. Papasavvas, A. Mexas, and K. Lynn, Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration, Journal of Infectious Diseases, vol.207, issue.2, pp.213-222
DOI : 10.1093/infdis/jis663

E. Baechler, J. Bauer, C. Slattery, W. Ortmann, and K. Espe, An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity, Mol Med, vol.13, issue.12, pp.59-68, 2007.

E. Baechler, F. Batliwalla, G. Karypis, P. Gaffney, and W. Ortmann, Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus, Proceedings of the National Academy of Sciences, vol.100, issue.5, pp.2610-2615, 2003.
DOI : 10.1073/pnas.0337679100

J. Banchereau and V. Pascual, Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases, Immunity, vol.25, issue.3, pp.383-392, 2006.
DOI : 10.1016/j.immuni.2006.08.010

J. Baumann, D. Unutmaz, M. Miller, S. Breun, and S. Grill, Murine T Cells Potently Restrict Human Immunodeficiency Virus Infection, Journal of Virology, vol.78, issue.22, pp.12537-12547, 2004.
DOI : 10.1128/JVI.78.22.12537-12547.2004

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525105

L. Bennett, A. Palucka, E. Arce, V. Cantrell, and J. Borvak, Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood, The Journal of Experimental Medicine, vol.149, issue.6, pp.711-723, 2003.
DOI : 10.1136/ard.58.5.309

M. Berry, C. Graham, F. Mcnab, Z. Xu, and S. Bloch, An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis, Nature, vol.195, issue.7309, pp.973-977
DOI : 10.1038/nature09247

E. Borden, G. Sen, G. Uze, R. Silverman, and R. Ransohoff, Interferons at age 50: past, current and future impact on biomedicine, Nature Reviews Drug Discovery, vol.56, issue.12, pp.975-990, 2007.
DOI : 10.1038/nrd2422

URL : https://hal.archives-ouvertes.fr/hal-00203077

J. Brenchley, M. Paiardini, K. Knox, A. Asher, and B. Cervasi, Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections, Blood, vol.112, issue.7, pp.2826-2835, 2008.
DOI : 10.1182/blood-2008-05-159301

M. Chawla-sarkar, D. Lindner, Y. Liu, B. Williams, and G. Sen, Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis, Apoptosis, vol.8, issue.3, pp.237-249, 2003.
DOI : 10.1023/A:1023668705040

M. De-veer, M. Holko, M. Frevel, E. Walker, and S. Der, Functional classification of interferon-stimulated genes identified using microarrays, J Leukoc Biol, vol.69, issue.6, pp.912-920, 2001.

T. Decker, M. Muller, and S. Stockinger, The Yin and Yang of type I interferon activity in bacterial infection, Nature Reviews Immunology, vol.264, issue.9, pp.675-687, 2005.
DOI : 10.1016/j.it.2004.08.010

N. Dikopoulos, A. Bertoletti, A. Kroger, H. Hauser, and R. Schirmbeck, Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells, The Journal of Immunology, vol.174, issue.1, pp.99-109, 2005.
DOI : 10.4049/jimmunol.174.1.99

E. Dondi, L. Rogge, G. Lutfalla, G. Uze, and S. Pellegrini, Down-Modulation of Responses to Type I IFN Upon T Cell Activation, The Journal of Immunology, vol.170, issue.2, pp.749-756, 2003.
DOI : 10.4049/jimmunol.170.2.749

E. Esplugues, S. Huber, N. Gagliani, A. Hauser, and T. Town, Control of TH17 cells occurs in the small intestine, Nature, vol.155, issue.7357, pp.514-518
DOI : 10.1038/nature10228

A. Garcia-sastre and C. Biron, Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente, Science, vol.312, issue.5775, pp.879-882, 2006.
DOI : 10.1126/science.1125676

A. Gosselin, P. Monteiro, N. Chomont, F. Diaz-griffero, and E. Said, Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection, The Journal of Immunology, vol.184, issue.3, pp.1604-1616
DOI : 10.4049/jimmunol.0903058

C. Goujon and M. Malim, Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T Cells, Journal of Virology, vol.84, issue.18, pp.9254-9266
DOI : 10.1128/JVI.00854-10

C. Guiducci, R. Coffman, and F. Barrat, Signalling pathways leading to IFN-?? production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications, Journal of Internal Medicine, vol.204, issue.Pt 12, pp.43-57, 2009.
DOI : 10.1111/j.1365-2796.2008.02050.x

J. Huber, H. Ramos, M. Gill, and J. Farrar, Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3, The Journal of Immunology, vol.185, issue.2, pp.813-817
DOI : 10.4049/jimmunol.1000469

S. Indraccolo, U. Pfeffer, S. Minuzzo, G. Esposito, and R. V. , Identification of Genes Selectively Regulated by IFNs in Endothelial Cells, The Journal of Immunology, vol.178, issue.2, pp.1122-1135, 2007.
DOI : 10.4049/jimmunol.178.2.1122

A. Isaacs and J. Lindenmann, Virus Interference. I. The Interferon, Proceedings of the Royal Society B: Biological Sciences, vol.147, issue.927, pp.258-267, 1957.
DOI : 10.1098/rspb.1957.0048

C. Krause and S. Pestka, Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives, Pharmacology & Therapeutics, vol.106, issue.3, pp.299-346, 2005.
DOI : 10.1016/j.pharmthera.2004.12.002

S. Malucchi, F. Gilli, M. Caldano, F. Marnetto, and P. Valentino, Predictive markers for response to interferon therapy in patients with multiple sclerosis, Neurology, vol.70, issue.Issue 13, Part 2, pp.1119-1127, 2008.
DOI : 10.1212/01.wnl.0000304040.29080.7b

N. Manel, B. Hogstad, Y. Wang, D. Levy, and D. Unutmaz, A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells, Nature, vol.78, issue.7312, pp.214-217
DOI : 10.1038/nature09337

P. Marrack, J. Kappler, and T. Mitchell, Type I Interferons Keep Activated T Cells Alive, The Journal of Experimental Medicine, vol.29, issue.3, pp.521-530, 1999.
DOI : 10.1097/00002281-199707000-00011

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192920

J. Merrill, D. Wallace, M. Petri, K. Kirou, and Y. Yao, Safety profile and clinical activity of sifalimumab, a fully human anti-interferon ?? monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study, Annals of the Rheumatic Diseases, vol.70, issue.11, pp.1905-1913
DOI : 10.1136/ard.2010.144485

Y. Miyazaki, S. Miyake, A. Chiba, and O. Lantz, Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis, International Immunology, vol.23, issue.9, pp.529-535
DOI : 10.1093/intimm/dxr047

A. Moschen, S. Geiger, I. Krehan, A. Kaser, and H. Tilg, Interferon-alpha controls IL-17 expression in vitro and in vivo, Immunobiology, vol.213, issue.9-10, pp.9-10, 2008.
DOI : 10.1016/j.imbio.2008.07.022

M. Prchal, A. Pilz, O. Simma, K. Lingnau, and A. Von-gabain, Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity, Vaccine, vol.27, issue.6, pp.17-20, 2009.
DOI : 10.1016/j.vaccine.2009.10.016

M. Prinz, H. Schmidt, A. Mildner, K. Knobeloch, and U. Hanisch, Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System, Immunity, vol.28, issue.5, pp.675-686, 2008.
DOI : 10.1016/j.immuni.2008.03.011

L. Rogge, D. Ambrosio, D. Biffi, M. Penna, G. Minetti et al., The role of Stat4 in species-specific regulation of Th cell development by type I IFNs, J Immunol, vol.161, issue.12, pp.6567-6574, 1998.

J. Schoggins, S. Wilson, M. Panis, M. Murphy, and C. Jones, A diverse range of gene products are effectors of the type I interferon antiviral response, Nature, vol.81, issue.7344, pp.481-485
DOI : 10.1038/nature09907

E. Schutyser, S. Struyf, and J. Van-damme, The CC chemokine CCL20 and its receptor CCR6, Cytokine & Growth Factor Reviews, vol.14, issue.5, pp.409-426, 2003.
DOI : 10.1016/S1359-6101(03)00049-2

P. Serrano-fernandez, S. Moller, R. Goertsches, H. Fiedler, and D. Koczan, Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis, Autoimmunity, vol.24, issue.4, pp.172-178
DOI : 10.1016/j.jneuroim.2004.01.002

A. Theofilopoulos, R. Baccala, B. Beutler, and D. Kono, TYPE I INTERFERONS (??/??) IN IMMUNITY AND AUTOIMMUNITY, Annual Review of Immunology, vol.23, issue.1, pp.307-336, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115843

E. Volpe, N. Servant, R. Zollinger, S. Bogiatzi, and P. Hupe, A critical function for transforming growth factor-??, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses, Nature Immunology, vol.174, issue.6, pp.650-657, 2008.
DOI : 10.1084/jem.20012076

E. Volpe, M. Touzot, N. Servant, M. Marloie-provost, and P. Hupe, Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production, Blood, vol.114, issue.17, pp.3610-3614, 2009.
DOI : 10.1182/blood-2009-05-223768

B. Weinstock-guttman, D. Badgett, K. Patrick, L. Hartrich, and R. Santos, Genomic Effects of IFN-?? in Multiple Sclerosis Patients, The Journal of Immunology, vol.171, issue.5, pp.2694-2702, 2003.
DOI : 10.4049/jimmunol.171.5.2694

M. Wong, J. Ye, M. Alonso, A. Landrigan, and R. Cheung, Regulation of human Th9 differentiation by type I interferons and IL-21, Immunology and Cell Biology, vol.178, issue.6, pp.624-631
DOI : 10.1084/jem.20081886

L. Zhou, M. Chong, and D. Littman, Plasticity of CD4+ T Cell Lineage Differentiation, Immunity, vol.30, issue.5, pp.646-655, 2009.
DOI : 10.1016/j.immuni.2009.05.001

M. Greter, J. Helft, A. Chow, D. Hashimoto, A. Mortha et al., GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells, Immunity, vol.36, issue.6, pp.1031-1046, 2012.
DOI : 10.1016/j.immuni.2012.03.027

M. Guilliams, K. Movahedi, T. Bosschaerts, T. Vandendriessche, M. K. Chuah et al., IL-10 dampens TNF/inducible nitric oxide synthaseproducing dendritic cell-mediated pathogenicity during parasitic infection, 2009.
DOI : 10.4049/jimmunol.182.2.1107

H. Hammad, M. Plantinga, K. Deswarte, P. Pouliot, M. A. Willart et al., Inflammatory dendritic cells???not basophils???are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen, The Journal of Experimental Medicine, vol.21, issue.10, pp.2097-2111, 2010.
DOI : 10.1016/S0092-8674(00)80240-8

A. Hansel, C. Gunther, J. Ingwersen, J. Starke, M. Schmitz et al., Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong Th17/Th1 T-cell responses, Journal of Allergy and Clinical Immunology, vol.127, issue.3, pp.787-794, 2011.
DOI : 10.1016/j.jaci.2010.12.009

W. R. Heath and F. R. Carbone, Dendritic cell subsets in primary and secondary T cell responses at body surfaces, Nature Immunology, vol.180, issue.12, pp.1237-1244, 2009.
DOI : 10.1084/jem.20041961

H. H. Hofstetter, S. M. Ibrahim, D. Koczan, N. Kruse, A. Weishaupt et al., Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis, Cellular Immunology, vol.237, issue.2, pp.123-130, 2005.
DOI : 10.1016/j.cellimm.2005.11.002

Y. Hu, F. Shen, N. K. Crellin, and W. Ouyang, The IL-17 pathway as a major therapeutic target in autoimmune diseases, Annals of the New York Academy of Sciences, vol.62, issue.Suppl 3, pp.60-76, 2011.
DOI : 10.1111/j.1749-6632.2010.05825.x

I. I. Ivanov, B. S. Mckenzie, L. Zhou, C. E. Tadokoro, A. Lepelley et al., The Orphan Nuclear Receptor ROR??t Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells, Cell, vol.126, issue.6, pp.1121-1133, 2006.
DOI : 10.1016/j.cell.2006.07.035

A. B. Kimball, K. B. Gordon, R. G. Langley, A. Menter, E. K. Chartash et al., Safety and Efficacy of ABT-874, a Fully Human Interleukin 12/23 Monoclonal Antibody, in the Treatment of Moderate to Severe Chronic Plaque Psoriasis, Archives of Dermatology, vol.144, issue.2, pp.200-207, 2008.
DOI : 10.1001/archdermatol.2007.63

E. Klechevsky, R. Morita, M. Liu, Y. Cao, S. Coquery et al., Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells, Immunity, vol.29, issue.3, pp.497-510, 2008.
DOI : 10.1016/j.immuni.2008.07.013

M. Kool, T. Soullié, M. Van-nimwegen, M. A. Willart, F. Muskens et al., Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells, The Journal of Experimental Medicine, vol.25, issue.4, pp.869-882, 2008.
DOI : 10.1084/jem.20040035

G. G. Krueger, R. G. Langley, C. Leonardi, N. Yeilding, C. Guzzo et al., A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis, CNTO 1275 Psoriasis Study Group, pp.580-592, 2007.
DOI : 10.1056/NEJMoa062382

B. Leó-n, M. Ló-pez-bravo, and C. Ardavín, Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the Induction of Protective T Helper 1 Responses against Leishmania, Immunity, vol.26, issue.4, pp.519-531, 2007.
DOI : 10.1016/j.immuni.2007.01.017

N. Manel, D. Unutmaz, and D. R. Littman, The differentiation of human TH-17 cells requires transforming growth factor-?? and induction of the nuclear receptor ROR??t, Nature Immunology, vol.171, issue.6, pp.641-649, 2008.
DOI : 10.1084/jem.189.11.1735

M. Merad and M. G. Manz, Dendritic cell homeostasis, Blood, vol.113, issue.15, pp.3418-3427, 2009.
DOI : 10.1182/blood-2008-12-180646

M. M. Meredith, K. Liu, G. Darrasse-jeze, A. O. Kamphorst, H. A. Schreiber et al., Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage, The Journal of Experimental Medicine, vol.19, issue.6, pp.1153-1165, 2012.
DOI : 10.1016/j.immuni.2005.03.005

S. H. Naik, D. Metcalf, A. Van-nieuwenhuijze, I. Wicks, L. Wu et al., Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes, Nature Immunology, vol.99, issue.6, pp.663-671, 2006.
DOI : 10.1038/ni1340

H. Nakano, K. L. Lin, M. Yanagita, C. Charbonneau, D. N. Cook et al., Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses, Nature Immunology, vol.27, issue.4, pp.394-402, 2009.
DOI : 10.1038/ni.1707

M. Nascimbeni, L. Perié, L. Chorro, S. Diocou, L. Kreitmann et al., Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-?? expression, Blood, vol.113, issue.24, pp.6112-6119, 2009.
DOI : 10.1182/blood-2008-07-170803

URL : https://hal.archives-ouvertes.fr/hal-00437706

N. Novak, R. Valenta, B. Bohle, S. Laffer, J. Haberstok et al., Fc??RI engagement of Langerhans cell???like dendritic cells and inflammatory dendritic epidermal cell???like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro???, Journal of Allergy and Clinical Immunology, vol.113, issue.5, pp.949-957, 2004.
DOI : 10.1016/j.jaci.2004.02.005

C. M. Paulos, C. Carpenito, G. Plesa, M. M. Suhoski, A. Varela-rohena et al., The inducible costimulator (ICOS) is critical for the development of human, 2010.

S. H. Robbins, T. Walzer, D. Dembé-lé, C. Thibault, A. Defays et al., Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling, Genome Biology, vol.9, issue.1, p.17, 2008.
DOI : 10.1186/gb-2008-9-1-r17

URL : https://hal.archives-ouvertes.fr/hal-00282558

F. Sallusto and A. Lanzavecchia, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, Journal of Experimental Medicine, vol.179, issue.4, pp.1109-1118, 1994.
DOI : 10.1084/jem.179.4.1109

W. J. Sandborn, B. G. Feagan, R. N. Fedorak, E. Scherl, M. R. Fleisher et al., A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease, Gastroenterology, vol.135, issue.4, pp.1130-1141, 2008.
DOI : 10.1053/j.gastro.2008.07.014

A. T. Satpathy, W. Kc, J. C. Albring, B. T. Edelson, N. M. Kretzer et al., expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages, The Journal of Experimental Medicine, vol.161, issue.6, pp.1135-1152, 2012.
DOI : 10.1016/j.immuni.2009.01.010

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371733

K. Schä-kel, R. Kannagi, B. Kniep, Y. Goto, C. Mitsuoka et al., 6-Sulfo LacNAc, a Novel Carbohydrate Modification of PSGL-1, Defines an Inflammatory Type of Human Dendritic Cells, Immunity, vol.17, issue.3, pp.289-301, 2002.
DOI : 10.1016/S1074-7613(02)00393-X

E. Segura, A. L. Albiston, I. P. Wicks, S. Y. Chai, and J. A. Villadangos, Different cross-presentation pathways in steady-state and inflammatory dendritic cells, Proc. Natl. Acad. Sci. USA, pp.20377-20381, 2009.
DOI : 10.1073/pnas.0910295106

E. Volpe, N. Servant, R. Zollinger, S. I. Bogiatzi, P. Hupé et al., A critical function for transforming growth factor-??, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses, Nature Immunology, vol.174, issue.6, pp.650-657, 2008.
DOI : 10.1084/jem.20012076

L. M. Wakim, J. Waithman, N. Van-rooijen, W. R. Heath, and F. R. Carbone, Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues, Science, vol.319, issue.5860, pp.198-202, 2008.
DOI : 10.1126/science.1151869

. Development, cytokine profile and function of human interleukin 17-producing helper T cells, Nat. Immunol, vol.8, pp.950-957

A. Wollenberg, S. Kraft, D. Hanau, and T. Bieber, Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema, Journal of Investigative Dermatology, vol.106, issue.3, pp.446-453, 1996.
DOI : 10.1111/1523-1747.ep12343596

A. Wollenberg, M. Mommaas, T. Oppel, E. M. Schottdorf, S. Gü-nther et al., Expression and Function of the Mannose Receptor CD206 on Epidermal Dendritic Cells in Inflammatory Skin Diseases, Journal of Investigative Dermatology, vol.118, issue.2, pp.327-334, 2002.
DOI : 10.1046/j.0022-202x.2001.01665.x

Y. Xu, Y. Zhan, A. M. Lew, S. H. Naik, and M. H. Kershaw, Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking, The Journal of Immunology, vol.179, issue.11, pp.7577-7584, 2007.
DOI : 10.4049/jimmunol.179.11.7577

L. C. Zaba, J. Fuentes-duculan, N. J. Eungdamrong, M. V. Abello, I. Novitskaya et al., Psoriasis Is Characterized by Accumulation of Immunostimulatory and Th1/Th17 Cell-Polarizing Myeloid Dendritic Cells, Journal of Investigative Dermatology, vol.129, issue.1, pp.79-88, 2009.
DOI : 10.1038/jid.2008.194

L. C. Zaba, J. Fuentes-duculan, N. J. Eungdamrong, L. M. Johnson-huang, K. E. Nograles et al., Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis, Journal of Allergy and Clinical Immunology, vol.125, issue.6, pp.1261-1268, 2010.
DOI : 10.1016/j.jaci.2010.03.018

W. Zheng and R. A. Flavell, The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells, Cell, vol.89, issue.4, pp.587-596, 1997.
DOI : 10.1016/S0092-8674(00)80240-8

W. Zou, R. , and N. P. , TH17 cells in tumour immunity and immunotherapy, Nature Reviews Immunology, vol.8, issue.4, pp.248-256, 2010.
DOI : 10.1038/nri2742

%. %. Donnelly, %. %sheikh, %. %. %kotenko, %. %&%dickensheets, %. A. %the%expanded%family%-of%class%ii%cytokines%that%share%the%ilt10%receptort2%-theofilopoulos et al., % 3% Type% I% interferons% (alpha/beta)% in% immunity% and% autoimmunity% 4.% Pestka,%S.%The%interferons:%50%years%after%their%discovery,%there%is%much%more%to% learn, Immunity Human Inflammatory DCs Induce Th17 Differentiation Immunity ª2013 Elsevier Inc. 13 REFERENCEILT10R2)%chain.%J%Leukoc%Biol% 76 Two% antigenically% distinct% species% of% human% interferon.% Proc% Natl%Acad%Sci%U%S%A%72 Evolution% of% the% Class% 2% cytokines% and% receptors,% and% discovery%of%new%friends%and%relatives.%Pharmacol%Ther%106,%299T346%(2005).% 7.% Diaz,%M.%O.%et%al.%Structure%of%the%human%typeTI%interferon%gene%cluster%determined% from%a%YAC%clone%contig.%Genomics%22 Mitsui,%Y.%&%Senda,%T.%Elucidation%of%the%basic%threeTdimensional%structure%of%type% I% interferons% and% its% functional% and% evolutionary% implications.% J% Interferon% Cytokine%Res%17% 9.% Schlaak,% J.% F.% et% al.% CellTtype% and% donorTspecific% transcriptional% responses% to% interferonTalpha.% Use% of% customized% gene% arrays.% J% Biol% Chem% 277, pp.1-13, 1957.

%. Lafleur and %. D. Interferontkappa, Interferon-??, a Novel Type I Interferon Expressed in Human Keratinocytes, Journal of Biological Chemistry, vol.276, issue.43, pp.39765-71, 2001.
DOI : 10.1074/jbc.M102502200

%. Van%-boxeltdezaire, %. A. Rani, %. M. &%, and %. G. Stark, Complex% modulation% of% cell% typeTspecific% signaling% in% response% to% type% I% interferons, pp.361-72, 2006.

%. Medzhitov and %. R. , Recognition of microorganisms and activation of the immune response, Nature, vol.158, issue.7164, pp.819-845, 2007.
DOI : 10.1038/nature06246

%. Medzhitov, %. R. &%-janeway, and %. C. Jr, Innate Immunity: The Virtues of a Nonclonal System of Recognition, Cell, vol.91, issue.3, pp.295-303, 1997.
DOI : 10.1016/S0092-8674(00)80412-2

%. Trinchieri and %. , %Type%I%interferon:%friend%or%foe?%J%Exp%Med%207
DOI : 10.1084/jem.20101664

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947062

%. Andrejeva and %. , %The%V%proteins%of%paramyxoviruses%bind%the%IFNTinducible%RNA% helicase,% mdaT5,% and% inhibit% its% activation% of% the% IFNTbeta% promoter, Proc% Natl% Acad%Sci%U%S%A%101, pp.17264-17273, 2004.

%. Ishikawa and %. H. &%-barber, % STING% is% an% endoplasmic% reticulum% adaptor% that% facilitates%innate%immune%signalling, pp.674-682, 2008.
DOI : 10.1038/nature07317

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804933

%. Pandey and %. A. , NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis, PLoS Pathogens, vol.204, issue.7, p.1000500, 2009.
DOI : 10.1371/journal.ppat.1000500.s005

%. Kawai and %. T. , % an% adaptor% triggering% RIGTIT% and% Mda5Tmediated% type% I% interferon%induction, pp.981-989, 2005.
DOI : 10.1038/ni1243

%. Cella and %. M. , Plasmacytoid% monocytes% migrate% to% inflamed% lymph% nodes% and% produce%large%amounts%of%type%I%interferon, pp.919-942, 1999.

%. Coccia and %. E. , Viral% infection% and% TollTlike% receptor% agonists% induce% a% differential%expression%of%type%I%and%lambda%interferons%in%human%plasmacytoid% and%monocyteTderived%dendritic%cells, pp.796-805, 2004.

%. Kumagai and %. , Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-?? Production in Plasmacytoid Dendritic Cells, The Journal of Immunology, vol.182, issue.7, pp.3960-3964, 2009.
DOI : 10.4049/jimmunol.0804315

%. Tovey and %. M. , Interferon messenger RNA is produced constitutively in the organs of normal individuals., Proceedings of the National Academy of Sciences, vol.84, issue.14, pp.5038-5080, 1987.
DOI : 10.1073/pnas.84.14.5038

%. Christensen and %. J. , Differential% impact% of% interferon% regulatory% factor% 7% in% initiation% of% the% type% I% interferon% response% in% the% lymphocytic% choriomeningitis% virusTinfected%central%nervous%system%versus%the%periphery.%J%Virol%86, pp.7384-92

%. Bourne and %. N. , Early% production% of% type% I% interferon% during% West% Nile% virus% infection:%role%for%lymphoid%tissues%in%IRF3Tindependent%interferon%production.%J% Virol%81, pp.9100-9108, 2007.

%. Malleret and %. B. , Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression, Blood, vol.112, issue.12, pp.4598-608, 2008.
DOI : 10.1182/blood-2008-06-162651

URL : https://hal.archives-ouvertes.fr/hal-00345337

%. Bangert, %. , %. %stary, %. , %. %&%kopp et al., %Immunopathologic%features%of% allergic% contact% dermatitis% in% humans:% participation% of% plasmacytoid% dendritic% cells%in%the%pathogenesis%of%the%disease?%J%Invest%Dermatol%121, pp.1409-1427, 2003.

%. Baumgart and %. D. , Aberrant% plasmacytoid% dendritic% cell% distribution% and% function%in%patients%with%Crohn's%disease%and%ulcerative%colitis.%Clin%Exp%Immunol% 166

%. Cavanagh and %. L. , Rheumatoid% arthritis% synovium% contains% plasmacytoid% dendritic%cells, pp.230-270, 2005.

%. Lande and %. R. , Plasmacytoid% dendritic% cells% in% multiple% sclerosis:% intracerebral% recruitment% and% impaired% maturation% in% response% to% interferonTbeta.% J% Neuropathol%Exp%Neurol%67, pp.388-401, 2008.

%. Demoulins and %. T. , Poly (I:C) induced immune response in lymphoid tissues involves three sequential waves of type I IFN expression, Virology, vol.386, issue.2, pp.225-261, 2009.
DOI : 10.1016/j.virol.2009.01.024

%. Bach, %. %. %aguet, %. %&%schreiber, and %. %d, %The%IFN%gamma%receptor:%a%paradigm%for% cytokine%receptor%signaling, pp.563-91, 1997.

%. Jaitin and %. D. , Inquiring% into% the% differential% action% of% interferons% (IFNs):% an% IFNTalpha2% mutant% with% enhanced% affinity% to% IFNAR1% is% functionally% similar% to% IFNTbeta, pp.1888-97, 2006.

%. Severa and %. , Differential responsiveness to IFN-?? and IFN-?? of human mature DC through modulation of IFNAR expression, Journal of Leukocyte Biology, vol.79, issue.6, pp.1286-94, 2006.
DOI : 10.1189/jlb.1205742

URL : https://hal.archives-ouvertes.fr/pasteur-00161981

%. De%-veer and %. M. , Functional% classification% of% interferonTstimulated% genes% identified%using%microarrays, pp.912-932, 2001.

%. Cao and %. W. , TollTlike% receptorTmediated% induction% of% type% I% interferon% in% plasmacytoid% dendritic% cells% requires% the% rapamycinTsensitive% PI(3)KTmTORT p70S6K%pathway, pp.1157-64, 2008.

%. Kaur and %. S. , Role% of% the% Akt% pathway% in% mRNA% translation% of% interferonT stimulated%genes, pp.4808-4821, 2008.

%. Li and %. , %Free%cholesterolTloaded%macrophages%are%an%abundant%source%of%tumor% necrosis% factorTalpha% and% interleukinT6:% model% of% NFTkappaBT% and% map% kinaseT dependent%inflammation%in%advanced%atherosclerosis, pp.21763-72, 2005.

%. David and %. , Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins, Science, vol.269, issue.5231, pp.1721-1724, 1995.
DOI : 10.1126/science.7569900

%. Romerio, %. F. &%-zella, and %. D. , % MEK% and% ERK% inhibitors% enhance% the% antiTproliferative% effect%of%interferonTalpha2b, pp.1680-1682, 2002.

%. Panaretakis and %. , %Interferon%alpha%induces%nucleusTindependent%apoptosis%by% activating% extracellular% signalTregulated% kinase% 1/2% and% cTJun% NH2Tterminal% kinase% downstream% of% phosphatidylinositol% 3Tkinase% and% mammalian% target% of% rapamycin, pp.41-50, 2008.

%. Pedersen and %. , %M.%et%al.%Interferon%modulation%of%cellular%microRNAs%as%an%antiviral% mechanism, pp.919-941, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01216316

%. Ohno and %. , %The%modulation%of%microRNAs%by%type%I%IFN%through%the%activation% of% signal% transducers% and% activators% of% transcription% 3% in% human% glioma.% Mol% Cancer%Res%7, pp.2022-2052, 2009.

%. Litvak and %. V. , A% FOXO3TIRF7% gene% regulatory% circuit% limits% inflammatory% sequelae%of%antiviral%responses.%Nature%490

%. Larner, %. A. Chaudhuri, %. A. Darnell, and %. J. , % Transcriptional% induction% by% interferon.% New% protein(s)% determine% the% extent% and% length% of% the% induction, pp.453-462, 1986.

%. Levy, %. D. Larner, %. A. Chaudhuri, %. A. Babiss, %. L. Darnell et al., InterferonT stimulated% transcription:% isolation% of% an% inducible% gene% and% identification% of% its% regulatory%region, pp.8929-8962, 1986.

%. Der, %. S. Zhou, %. A. Williams, %. B. &%-silverman, and %. R. , % Identification% of% genes% differentially%regulated%by%interferon%alpha,%beta,%or%gamma%using%oligonucleotide% arrays, pp.15623-15631, 1998.

%. Indraccolo and %. S. , Identification of Genes Selectively Regulated by IFNs in Endothelial Cells, The Journal of Immunology, vol.178, issue.2, pp.1122-1157, 2007.
DOI : 10.4049/jimmunol.178.2.1122

%. Certa, %. %wilhelmtseiler, %. %foser, %. %broger, %. %&%neeb et al., Expression modes of interferon-?? inducible genes in sensitive and resistant human melanoma cells stimulated with regular and pegylated interferon-??, Gene, vol.315, pp.79-86, 2003.
DOI : 10.1016/S0378-1119(03)00722-4

%. Certa, %. U. Seiler, %. M. Padovan, %. E. &%-spagnoli, and %. G. , % High% density% oligonucleotide% array% analysis% of% interferonT% alpha2a% sensitivity% and% transcriptional% response% in% melanoma%cells, pp.107-121, 2001.

%. Muller and %. U. , Functional role of type I and type II interferons in antiviral defense, Science, vol.264, issue.5167, pp.1918-1939, 1994.
DOI : 10.1126/science.8009221

%. Connell and %. R. , Type% I% interferon% production% enhances% susceptibility% to% Listeria%monocytogenes%infection, pp.437-482, 2004.

%. Casrouge and %. A. , Herpes% simplex% virus% encephalitis% in% human% UNCT93B% deficiency, pp.308-320, 2006.

%. Dupuis and %. S. , Impaired% response% to% interferonTalpha/beta% and% lethal% viral% disease%in%human%STAT1%deficiency, pp.388-91, 2003.

%. Brass and %. A. , The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus, Cell, vol.139, issue.7, pp.1243-54, 2009.
DOI : 10.1016/j.cell.2009.12.017

%. Zhao and %. , %et%al.%The%UbcH8%ubiquitin%E2%enzyme%is%also%the%E2%enzyme%for%ISG15,%an% IFNTalpha/betaTinduced% ubiquitinTlike% protein, Proc% Natl% Acad% Sci% U% S% A% 101, pp.7578-82, 2004.
URL : https://hal.archives-ouvertes.fr/in2p3-00755901

%. Lenschow and %. D. , IFNTstimulated% gene% 15% functions% as% a% critical% antiviral% molecule%against%influenza,%herpes,%and%Sindbis%viruses, pp.1371-1377, 2007.

%. Haller, %. O. Arnheiter, %. H. Lindenmann, %. J. &%-gresser, and %. I. , Host gene influences sensitivity to interferon action selectively for influenza virus, Nature, vol.115, issue.5748, pp.660-662, 1980.
DOI : 10.1038/283660a0

%. Balachandran and %. S. , Essential% role% for% the% dsRNATdependent% protein% kinase% PKR%in%innate%immunity%to%viral%infection, pp.129-170, 2000.

%. Boasso, %. %hardy, %. %. %anderson, %. %. %dolan, %. %. %&%shearer et al., %HIVTinduced% type% I% interferon% and% tryptophan% catabolism% drive% T% cell% dysfunction% despite% phenotypic%activation, p.2961, 2008.
DOI : 10.1371/journal.pone.0002961

URL : http://doi.org/10.1371/journal.pone.0002961

%. Nagarajan and %. U. , % Induction% and% function% of% IFNbeta% during% viral% and% bacterial% infection.%Crit%Rev%Immunol%31

%. Mancuso and %. G. , Type I IFN Signaling Is Crucial for Host Resistance against Different Species of Pathogenic Bacteria, The Journal of Immunology, vol.178, issue.5, pp.3126-3159, 2007.
DOI : 10.4049/jimmunol.178.5.3126

%. Ishihara and %. T. , Inhibition% of% chlamydia% trachomatis% growth% by% human% interferonTalpha:%mechanisms%and%synergistic%effect%with%interferonTgamma%and% tumor%necrosis%factorTalpha, pp.179-85, 2005.

%. Sotolongo and %. J. , Host% innate% recognition% of% an% intestinal% bacterial% pathogen% induces%TRIFTdependent%protective%immunity.%J%Exp%Med%208

%. Buss and %. C. , Essential% role% of% mitochondrial% antiviral% signaling,% IFN% regulatory% factor% (IRF)3,% and% IRF7% in% Chlamydophila% pneumoniaeTmediated% IFNTbeta% response% and% control% of% bacterial% replication% in% human% endothelial% cells

%. Stockinger, %. S. &%-decker, and %. T. , Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes, Immunobiology, vol.213, issue.9-10, pp.889-97, 2008.
DOI : 10.1016/j.imbio.2008.07.020

%. Manca and %. , %et%al.%Hypervirulent%M.%tuberculosis%W/Beijing%strains%upregulate%type%I% IFNs% and% increase% expression% of% negative% regulators% of% the% JakTStat% pathway, pp.694-701, 2005.

%. Miller, %. J. Ma, %. Y. Crandall, %. H. Wang, %. X. &%-weis et al., Gene expression profiling provides insights into the pathways involved in inflammatory arthritis development: Murine model of Lyme disease, Experimental and Molecular Pathology, vol.85, issue.1, pp.20-27, 2008.
DOI : 10.1016/j.yexmp.2008.03.004

%. Litinskiy and %. M. , DCs% induce% CD40Tindependent% immunoglobulin% class% switching%through%BLyS%and%APRIL, pp.822-831, 2002.
DOI : 10.1038/ni829

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621779

%. Lin, %. Q. Dong, %. C. &%-cooper, and %. M. , Impairment of ???T and B Cell Development by Treatment with a Type I Interferon, The Journal of Experimental Medicine, vol.154, issue.1, pp.79-87, 1998.
DOI : 10.1084/jem.185.3.517

%. Chawlatsarkar and %. , %Apoptosis%and%interferons:%role%of%interferonTstimulated% genes%as%mediators%of%apoptosis, pp.237-286, 2003.

%. Lepelletier and %. , %TollTlike%receptor%control%of%glucocorticoidTinduced%apoptosis% in%human%plasmacytoid%predendritic%cells%(pDCs).%Blood%116,%3389T97

%. Bocci and %. V. , % Is% interferon% produced% in% physiologic% conditions?% Med% Hypotheses% 6, pp.735-780, 1980.

%. Balachandran, %. %&%beg, and %. %a, %Defining%emerging%roles%for%NFTkappaB%in%antivirus% responses:%revisiting%the%interferonTbeta%enhanceosome%paradigm.%PLoS%Pathog%7,% e1002165

%. Senger and %. K. , Gene Repression by Coactivator Repulsion, Molecular Cell, vol.6, issue.4, pp.931-938, 2000.
DOI : 10.1016/S1097-2765(05)00081-X

%. Mitani and %. Y. , Cross% talk% of% the% interferonTalpha/beta% signalling% complex% with% gp130%for%effective%interleukinT6%signalling, pp.631-671, 2001.

%. Lee, %. %. %smith, %. %gimeno, %. %gertner, %. %&%levy et al., %STAT1%affects%lymphocyte% survival% and% proliferation% partially% independent% of% its% role% downstream% of% IFNT gamma, pp.1286-92, 2000.

%. Swann and %. , %B.%et%al.%Type%I%IFN%contributes%to%NK%cell%homeostasis,%activation,%and% antitumor%function, pp.7540-7549, 2007.

%. Hwang and %. S. , A% null% mutation% in% the% gene% encoding% a% type% I% interferon% receptor% component% eliminates% antiproliferative% and% antiviral% responses% to% interferons%alpha%and%beta%and%alters%macrophage%responses.%Proc%Natl%Acad%Sci% U%S%A%92, pp.11284-11292, 1995.

%. Takayanagi and %. H. , RANKL% maintains% bone% homeostasis% through% cTFosT dependent%induction%of%interferonTbeta, pp.744-753, 2002.

%. Colamonici, %. %. %domanski, %. %platanias, %. %. %&%diaz, and %. %o, %Correlation%between% interferon% (IFN)% alpha% resistance% and% deletion% of% the% IFN% alpha/beta% genes% in% acute% leukemia% cell% lines% suggests% selection% against% the% IFN% system, % Blood%, vol.80, pp.744-753, 1992.

%. Landolfo and %. S. , Chronic% myeloid% leukemia% cells% resistant% to% interferonTalpha% lack%STAT1%expression, pp.7-14, 2000.

%. Paquette and %. R. , InterferonTalpha% and% granulocyteTmacrophage% colonyT stimulating%factor%differentiate%peripheral%blood%monocytes%into%potent%antigenT presenting%cells, pp.358-67, 1998.

%. Dalod and %. M. , Dendritic% cell% responses% to% early% murine% cytomegalovirus% infection:% subset% functional% specialization% and% differential% regulation% by% interferon%alpha/beta, pp.885-98, 2003.

%. Trinchieri, %. %santoli, %. %dee, %. %. %&%knowles, and %. %b, %AntiTviral%activity%induced%by% culturing% lymphocytes% with% tumorTderived% or% virusTtransformed% cells.% Identification% of% the% antiTviral% activity% as% interferon% and% characterization% of% the% human%effector%lymphocyte%subpopulation, pp.1299-1313, 1978.

%. Nguyen and %. , %B.%et%al.%Coordinated%and%distinct%roles%for%IFNTalpha%beta,%ILT12,%and% ILT15%regulation%of%NK%cell%responses%to%viral%infection, pp.4279-87, 2002.
URL : https://hal.archives-ouvertes.fr/in2p3-00945236

%. Kadowaki, %. N. &%-liu, and %. Y. , % Natural% type% I% interferonTproducing% cells% as% a% link% between%innate%and%adaptive%immunity, pp.1126-1158, 2002.

%. Le%bon and %. , Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo, Immunity, vol.14, issue.4, pp.461-70, 2001.
DOI : 10.1016/S1074-7613(01)00126-1

%. Jego and %. G. , Plasmacytoid Dendritic Cells Induce Plasma Cell Differentiation through Type I Interferon and Interleukin 6, Immunity, vol.19, issue.2, pp.225-259, 2003.
DOI : 10.1016/S1074-7613(03)00208-5

%. Poeck and %. , %et%al.%Plasmacytoid%dendritic%cells,%antigen,%and%CpGTC%license%human%B% cells% for% plasma% cell% differentiation% and% immunoglobulin% production% in% the% absence%of%TTcell%help, pp.3058-64, 2004.

%. Rogge and %. L. , The% role% of% Stat4% in% speciesTspecific% regulation% of% Th% cell% development%by%type%I%IFNs, pp.6567-74, 1998.

%. Schandene and %. L. , Interferon% alpha% prevents% spontaneous% apoptosis% of% clonal% Th2%cells%associated%with%chronic%hypereosinophilia, pp.4285-92, 2000.

%. Mosmann, %. %. %cherwinski, %. %bond, %. %. %giedlin, %. %. %&%coffman et al., %Two% types% of% murine% helper% T% cell% clone.% I.% Definition% according% to% profiles% of% lymphokine%activities%and%secreted%proteins, pp.2348-57, 1986.

%. Sakaguchi and %. S. , % Regulatory% T% cells:% key% controllers% of% immunologic% selfTtolerance, pp.455-463, 2000.

%. Park and %. H. , A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nature Immunology, vol.103, issue.11, pp.1133-1174, 2005.
DOI : 10.1038/35051100

%. Ivanov and %. Ii%, The% orphan% nuclear% receptor% RORgammat% directs% the% differentiation%program%of%proinflammatory%ILT17+%T%helper%cells, pp.1121-1154, 2006.

%. Zhu, %. %&%paul, and %. %e, CD4 T cells: fates, functions, and faults, Blood, vol.112, issue.5, pp.1557-69, 2008.
DOI : 10.1182/blood-2008-05-078154

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518872

%. Guo and %. L. , ILT1% family% members% and% STAT% activators% induce% cytokine% production% by% Th2, Th17,% and% Th1% cells.% Proc% Natl% Acad% Sci% U% S% A% 106, pp.13463-13471, 2009.

%. Tran, %. %. %ramsey, %. %&%shevach, and %. , Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-?? dependent but does not confer a regulatory phenotype, Blood, vol.110, issue.8, pp.2983-90, 2007.
DOI : 10.1182/blood-2007-06-094656

%. Veldhoen, %. M. Hocking, %. R. Flavell, %. R. &%-stockinger, and %. B. , % Signals% mediated% by% transforming% growth% factorTbeta% initiate% autoimmune% encephalomyelitis,% but% chronic% inflammation% is% needed% to% sustain% disease, pp.1151-1157, 2006.

%. Volpe and %. , %et%al.%A%critical%function%for%transforming%growth%factorTbeta,%interleukin% 23% and% proinflammatory% cytokines% in% driving% and% modulating% human% T(H)T17% responses, pp.650-657, 2008.
URL : https://hal.archives-ouvertes.fr/in2p3-00008702

%. Manel, %. %unutmaz, %. %&%littman, and %. %r, %The%differentiation%of%human%T(H)T17%cells% requires% transforming% growth% factorTbeta% and% induction% of% the% nuclear% receptor% RORgammat, pp.641-650, 2008.

%. Veldhoen, %. M. Hirota, %. K. Christensen, %. J. Garra, %. A. &%-stockinger et al., Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells, The Journal of Experimental Medicine, vol.126, issue.1, pp.43-52, 2009.
DOI : 10.1046/j.1523-1747.2000.00876.x

%. Ikeda and %. U. , % 1alpha,25TDihydroxyvitamin% D3% and% allTtrans% retinoic% acid% synergistically% inhibit% the% differentiation% and% expansion% of% Th17% cells

%. Thierfelder and %. W. , Requirement% for% Stat4% in% interleukinT12Tmediated% responses%of%natural%killer%and%T%cells, pp.171-175, 1996.

%. Afkarian and %. M. , TTbet% is% a% STAT1Tinduced% regulator% of% ILT12R% expression% in% naive%CD4+%T%cells, pp.549-57, 2002.

%. Nurieva and %. R. , Essential% autocrine% regulation% by% ILT21% in% the% generation% of% inflammatory%T%cells, pp.480-483, 2007.

%. Chen and %. Z. , Selective% regulatory% function% of% Socs3% in% the% formation% of% ILT17T secreting%T%cells, pp.8137-8179, 2006.

%. Yang and %. X. , T% helper% 17% lineage% differentiation% is% programmed% by% orphan% nuclear%receptors%ROR%alpha%and%ROR%gamma, pp.29-39, 2008.

%. Chi and %. H. , Regulation and function of mTOR signalling in T cell fate decisions, Nature Reviews Immunology, vol.177
DOI : 10.1038/nri3198

%. Valmori and %. D. , RapamycinTmediated% enrichment% of% T% cells% with% regulatory% activity%in%stimulated%CD4+%T%cell%cultures%is%not%due%to%the%selective%expansion%of% naturally%occurring%regulatory%T%cells%but%to%the%induction%of%regulatory%functions% in%conventional%CD4+%T%cells, pp.944-953, 2006.

%. Delgoffe and %. G. , The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment, Immunity, vol.30, issue.6, pp.832-876, 2009.
DOI : 10.1016/j.immuni.2009.04.014

%. Szabo and %. S. , Distinct% effects% of% TTbet% in% TH1% lineage% commitment% and% IFNT gamma%production%in%CD4%and%CD8%T%cells, pp.338-380, 2002.

%. Yamashita and %. M. , Identification% of% a% conserved% GATA3% response% element% upstream%proximal%from%the%interleukinT13%gene%locus, pp.42399-408, 2002.

%. Agarwal, %. S. Avni, %. O. &%-rao, and %. A. , % CellTtypeTrestricted% binding% of% the% transcription% factor%NFAT%to%a%distal%ILT4%enhancer%in%vivo, pp.643-52, 2000.

%. Mullen and %. A. , Hlx% is% induced% by% and% genetically% interacts% with% TTbet% to% promote%heritable%T(H)1%gene%induction, pp.652-660, 2002.

%. Zhu and %. J. , DownTregulation% of% GfiT1% expression% by% TGFTbeta% is% important% for% differentiation%of%Th17%and%CD103+%inducible%regulatory%T%cells, pp.329-370, 2009.

%. Koch and %. M. , The% transcription% factor% TTbet% controls% regulatory% T% cell% homeostasis%and%function%during%type%1%inflammation, pp.595-602, 2009.

%. Zhou and %. L. , TGFTbetaTinduced% Foxp3% inhibits% T(H)17% cell% differentiation% by% antagonizing%RORgammat%function, pp.236-276, 2008.

%. Veldhoen and %. M. , Transforming% growth% factorTbeta% 'reprograms'% the% differentiation% of% T% helper% 2% cells% and% promotes% an% interleukin% 9Tproducing% subset, pp.1341-1347, 2008.

%. Hayashi and %. N. , T% helper% 1% cells% stimulated% with% ovalbumin% and% ILT18% induce% airway% hyperresponsiveness% and% lung% fibrosis% by% IFNTgamma% and% ILT13% production, pp.14765-70, 2007.

%. Steinman, %. R. &%-cohn, and %. Z. , IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE: I. MORPHOLOGY, QUANTITATION, TISSUE DISTRIBUTION, Journal of Experimental Medicine, vol.137, issue.5, pp.1142-62, 1973.
DOI : 10.1084/jem.137.5.1142

%. Dzionek, %. A. Bdcat2, and %. Bdcat3, BDCA-2, BDCA-3, and BDCA-4: Three Markers for Distinct Subsets of Dendritic Cells in Human Peripheral Blood, The Journal of Immunology, vol.165, issue.11, pp.6037-6083, 2000.
DOI : 10.4049/jimmunol.165.11.6037

%. Liu and %. Y. , Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity, Cell, vol.106, issue.3, pp.259-62, 2001.
DOI : 10.1016/S0092-8674(01)00456-1

%. Leon, %. %lopeztbravo, %. %&%ardavin, and %. , %MonocyteTderived%dendritic%cells%formed% at% the% infection% site% control% the% induction% of% protective% T% helper% 1% responses% against%Leishmania, pp.519-550, 2007.

%. Talpaz and %. M. , % InterferonTalfaTbased% treatment% of% chronic% myeloid% leukemia% and% implications%of%signal%transduction%inhibition, pp.22-29, 2001.

%. Talpaz and %. M. , Phase% 1% study% of% polyethylene% glycol% formulation% of% interferon% alphaT2B% (Schering% 54031)% in% Philadelphia% chromosomeTpositive% chronic% myelogenous%leukemia, pp.1708-1721, 2001.

%. Kurzrock, %. R. Talpaz, %. M. &%-gutterman, and %. J. , Hairy cell leukaemia: review of treatment, British Journal of Haematology, vol.73, issue.s1, pp.17-20, 1991.
DOI : 10.1002/ajh.2830290102

%. Ferrantini, %. M. Capone, %. I. &%-belardelli, and %. F. , % InterferonTalpha% and% cancer:% mechanisms%of%action%and%new%perspectives%of%clinical%use, pp.884-93, 2007.

%. Borden and %. E. , Interferons at age 50: past, current and future impact on biomedicine, Nature Reviews Drug Discovery, vol.56, issue.12, pp.975-90, 2007.
DOI : 10.1038/nrd2422

URL : https://hal.archives-ouvertes.fr/hal-00203077

%. Mccarty, %. M. Bielenberg, %. D. Donawho, %. C. Bucana, %. C. &%-fidler et al., Evidence% for% the% causal% role% of% endogenous% interferonTalpha/beta% in% the% regulation% of% angiogenesis,% tumorigenicity,% and% metastasis% of% cutaneous% neoplasms, Clin% Exp% Metastasis%19, pp.609-624, 2002.

%. Greenberg and %. H. , Effect of Human Leukocyte Interferon on Hepatitis B Virus Infection in Patients with Chronic Active Hepatitis, New England Journal of Medicine, vol.295, issue.10, pp.517-539, 1976.
DOI : 10.1056/NEJM197609022951001

%. Hoofnagle and %. , %H.%et%al.%Randomized,%controlled%trial%of%recombinant%human%alphaT interferon% in% patients% with% chronic% hepatitis% B.% Gastroenterology% 95, pp.1318-1343, 1988.

%. Banchereau, %. J. &%-pascual, and %. V. , Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases, Immunity, vol.25, issue.3, pp.383-92, 2006.
DOI : 10.1016/j.immuni.2006.08.010

%. Tada, %. Y. Ho, %. A. Matsuyama, %. T. &%-mak, and %. T. , % Reduced% incidence% and% severity% of% antigenTinduced% autoimmune% diseases% in% mice% lacking% interferon% regulatory% factorT1, pp.231-239, 1997.

%. Nakazawa and %. T. , Complete% suppression% of% insulitis% and% diabetes% in% NOD% mice% lacking%interferon%regulatory%factorT1, pp.119-144, 2001.

%. Hida and %. S. , CD8(+)% T% cellTmediated% skin% disease% in% mice% lacking% IRFT2,% the% transcriptional%attenuator%of%interferonTalpha/beta%signaling.%Immunity%13, pp.643-55, 2000.

%. Touzot and %. M. , Polyarthritis% and% anemia% in% a% hemodialysis% patient:% systemic% lupus%erythematosus%following%treatment%with%interferon%alpha.%Clin%Nephrol%73,% 318T20

%. Bennett and %. L. , Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood, The Journal of Experimental Medicine, vol.149, issue.6, pp.711-734, 2003.
DOI : 10.1136/ard.58.5.309

%. Emamian and %. E. , Peripheral blood gene expression profiling in Sj??gren's syndrome, Genes and Immunity, vol.14, issue.4, pp.285-96, 2009.
DOI : 10.1073/pnas.252784499

%. Reynier and %. F. , Importance% of% correlation% between% gene% expression% levels:% application%to%the%type%I%interferon%signature%in%rheumatoid%arthritis.%PLoS%One%6,% e24828

%. Niewold and %. , %B.%et%al.%IRF5%haplotypes%demonstrate%diverse%serological%associations% which% predict% serum% interferon% alpha% activity% and% explain% the% majority% of% the% genetic%association%with%systemic%lupus%erythematosus.%Ann%Rheum%Dis%71

%. Korman and %. B. , Variant form of STAT4 is associated with primary Sj??gren's syndrome, Genes and Immunity, vol.56, issue.3, pp.267-70, 2008.
DOI : 10.1038/gene.2008.1

%. Fiehn and %. C. , Improved clinical outcome of lupus nephritis during the past decade: importance of early diagnosis and treatment, Annals of the Rheumatic Diseases, vol.62, issue.5, pp.435-444, 2003.
DOI : 10.1136/ard.62.5.435

%. Yao and %. Y. , Neutralization% of% interferonTalpha/betaTinducible% genes% and% downstream% effect% in% a% phase% I% trial% of% an% antiTinterferonTalpha% monoclonal% antibody%in%systemic%lupus%erythematosus, pp.1785-96, 2009.

%. Ronnblom, %. %&%pascual, and %. , The innate immune system in SLE: type I interferons and dendritic cells, Lupus, vol.9, issue.5, pp.394-403, 2008.
DOI : 10.1177/0961203308090020

%. Guiducci and %. C. , TLR% recognition% of% self% nucleic% acids% hampers% glucocorticoid% activity%in%lupus.%Nature%465

%. Lande and %. , %Neutrophils%activate%plasmacytoid%dendritic%cells%by%releasing%selfT DNATpeptide% complexes% in% systemic% lupus% erythematosus.% Sci% Transl% Med% 3,% 73ra19

%. Ganguly and %. D. , SelfTRNATantimicrobial% peptide% complexes% activate% human% dendritic%cells%through%TLR7%and%TLR8, pp.1983-94, 2009.

%. Lande and %. R. , Plasmacytoid% dendritic% cells% sense% selfTDNA% coupled% with% antimicrobial%peptide, pp.564-573, 2007.

%. Triantafyllopoulou and %. , Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages, Proc% Natl%Acad%Sci%U%S%A%107
DOI : 10.1073/pnas.0914902107

%. Le%bon and %. , Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN, The Journal of Immunology, vol.176, issue.4, pp.2074-2082, 2006.
DOI : 10.4049/jimmunol.176.4.2074

%. Joo and %. H. , Serum% from% patients% with% SLE% instructs% monocytes% to% promote% IgG% and%IgA%plasmablast%differentiation.%J%Exp%Med%209

%. Altaraji, %. A. &%-kidd, and %. D. Neurotbehcet, s% disease:% epidemiology,% clinical% characteristics,%and%management, pp.192-204, 2009.

%. Pena%-rossi and %. C. , Interferon% betaT1a% for% the% maintenance% of% remission% in% patients% with% Crohn's% disease:% results% of% a% phase% II% doseTfinding% study, BMC% Gastroenterol%9, p.22, 2009.

%. Bezbradica, %. J. &%-medzhitov, and %. R. , Integration% of% cytokine% and% heterologous% receptor%signaling%pathways, pp.333-342, 2009.

%. Shea, %. J. Gadina, %. M. &%-schreiber, and %. R. , % Cytokine% signaling% in% 2002:% new% surprises%in%the%Jak/Stat%pathway, pp.121-152, 2002.

%. Tassiulas and %. I. , Amplification of IFN-??-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors, Nature Immunology, vol.172, issue.11, pp.1181-1190, 2004.
DOI : 10.1038/ng1117

%. Ikushima, %. %&%miyazono, and %. , %Cellular%contextTdependent%"colors"%of%transforming% growth%factorTbeta%signaling.%Cancer%Sci%101

%. Ehata and %. , %Transforming%growth%factorTbeta%promotes%survival%of%mammary% carcinoma% cells% through% induction% of% antiapoptotic% transcription% factor% DEC1, pp.9694-703, 2007.

%. Sancheztelsner and %. T. , Synergistic% cooperation% between% hypoxia% and% transforming% growth% factorTbeta% pathways% on% human% vascular% endothelial% growth%factor%gene%expression, pp.38527-38562, 2001.

%. Budagian and %. V. , A% promiscuous% liaison% between% ILT15% receptor% and% Axl% receptor%tyrosine%kinase%in%cell%death%control, pp.4260-70, 2005.

%. Bulanova and %. E. , Mast% cells% express% novel% functional% ILT15% receptor% alpha% isoforms, pp.5045-55, 2003.

%. Veckman and %. V. , Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis, Journal of Leukocyte Biology, vol.74, issue.3, pp.395-402, 2003.
DOI : 10.1189/jlb.0402212

%. Malucchi and %. S. , Predictive markers for response to interferon therapy in patients with multiple sclerosis, Neurology, vol.70, issue.Issue 13, Part 2, pp.1119-1146, 2008.
DOI : 10.1212/01.wnl.0000304040.29080.7b

%. Baechler and %. , %C.%et%al.%InterferonTinducible%gene%expression%signature%in%peripheral% blood% cells% of% patients% with% severe% lupus, Proc% Natl% Acad% Sci% U% S% A% 100, pp.2610-2615, 2003.

%. Baechler and %. E. , An% interferon% signature% in% the% peripheral% blood% of% dermatomyositis%patients%is%associated%with%disease%activity, pp.59-68, 2007.

P. <. Mcdermott and M. , 01. àP < .001 A proposed classification of the immunological diseases, J ALLERGY CLIN IMMUNOL PLoS Med, vol.3, p.297, 2006.

T. Sakane, M. Takeno, N. Suzuki, and G. Inaba, Beh??et's Disease, New England Journal of Medicine, vol.341, issue.17, pp.1284-91, 1999.
DOI : 10.1056/NEJM199910213411707

D. Saadoun, B. Wechsler, K. Desseaux, L. T. Huong, D. Amoura et al., Mortality in Beh??et's disease, Arthritis & Rheumatism, vol.43, issue.9, pp.2806-2818, 2010.
DOI : 10.1002/art.27568

S. Ohno, M. Ohguchi, S. Hirose, H. Matsuda, A. Wakisaka et al., Close Association of HLA-Bw51 With Behcet's Disease, Archives of Ophthalmology, vol.100, issue.9, pp.1455-1463, 1982.
DOI : 10.1001/archopht.1982.01030040433013

E. Remmers, F. Cosan, Y. Kirino, M. Ombrello, N. Abaci et al., Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh??et's disease, Nature Genetics, vol.335, issue.8, pp.698-702, 2010.
DOI : 10.1086/519795

N. Mizuki, A. Meguro, M. Ota, S. Ohno, T. Shiota et al., Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh??et's disease susceptibility loci, Nature Genetics, vol.335, issue.8, pp.703-709, 2010.
DOI : 10.1093/bioinformatics/bth457

S. Hirohata, Histopathology of central nervous system lesions in Beh??et's disease, Journal of the Neurological Sciences, vol.267, issue.1-2, pp.41-48, 2008.
DOI : 10.1016/j.jns.2007.09.041

A. Brustle, S. Heink, M. Huber, C. Rosenplanter, C. Stadelmann et al., The development of inflammatory TH-17 cells requires interferon-regulatory factor 4, Nature Immunology, vol.163, issue.9, pp.958-66, 2007.
DOI : 10.1016/j.jneuroim.2006.06.026

Q. Chen, Y. W. Gupta, S. Biswas, P. Smith, P. Bhagat et al., IRF-4-Binding Protein Inhibits Interleukin-17 and Interleukin-21 Production by Controlling the Activity of IRF-4 Transcription Factor, Immunity, vol.29, issue.6, pp.899-911, 2008.
DOI : 10.1016/j.immuni.2008.10.011

J. Deng, B. Younge, R. Olshen, J. Goronzy, and C. Weyand, Th17 and Th1 T-Cell Responses in Giant Cell Arteritis, Circulation, vol.121, issue.7, pp.906-921, 2010.
DOI : 10.1161/CIRCULATIONAHA.109.872903

F. Caprioli, M. Sarra, R. Caruso, C. Stolfi, D. Fina et al., Autocrine Regulation of IL-21 Production in Human T Lymphocytes, The Journal of Immunology, vol.180, issue.3, pp.1800-1807, 2008.
DOI : 10.4049/jimmunol.180.3.1800

R. Caruso, E. Botti, M. Sarra, M. Esposito, C. Stolfi et al., Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis, Nature Medicine, vol.180, issue.9, pp.1013-1018, 2009.
DOI : 10.1038/nm.1995

K. Ozaki, R. Spolski, R. Ettinger, H. Kim, G. Wang et al., Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6, The Journal of Immunology, vol.173, issue.9, pp.5361-71, 2004.
DOI : 10.4049/jimmunol.173.9.5361

M. Anderson and J. Bluestone, THE NOD MOUSE: A Model of Immune Dysregulation, Annual Review of Immunology, vol.23, issue.1, pp.447-85, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115643

R. Nurieva, X. Yang, G. Martinez, Y. Zhang, A. Panopoulos et al., Essential autocrine regulation by IL-21 in the generation of inflammatory T cells, Nature, vol.158, issue.7152, pp.480-483, 2007.
DOI : 10.1038/nature05969

C. Bucher, L. Koch, C. Vogtenhuber, E. Goren, M. Munger et al., IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation, Blood, vol.114, issue.26, pp.5375-84, 2009.
DOI : 10.1182/blood-2009-05-221135

J. Link, M. Soderstrom, T. Olsson, B. Hojeberg, A. Ljungdahl et al., Increased transforming growth factor-??, interleukin-4, and interferon-?? in multiple sclerosis, Annals of Neurology, vol.1032, issue.3, pp.379-86, 1994.
DOI : 10.1002/ana.410360309

D. Matusevicius, P. Kivisakk, B. He, N. Kostulas, V. Ozenci et al., Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis, Multiple Sclerosis Journal, vol.2, issue.2, pp.101-105, 1999.
DOI : 10.1177/135245859900500206

R. Ransohoff, P. Kivisakk, and G. Kidd, Three or more routes for leukocyte migration into the central nervous system, Nature Reviews Immunology, vol.3, issue.7, pp.569-81, 2003.
DOI : 10.1038/nri1130

B. Engelhardt, K. Wolburg-buchholz, and H. Wolburg, Involvement of the choroid plexus in central nervous system inflammation, Microscopy Research and Technique, vol.21, issue.1, pp.112-141, 2001.
DOI : 10.1002/1097-0029(20010101)52:1<112::AID-JEMT13>3.0.CO;2-5

A. Reboldi, C. Coisne, D. Baumjohann, F. Benvenuto, D. Bottinelli et al., C-C chemokine receptor 6???regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE, Nature Immunology, vol.181, issue.5, pp.514-537, 2009.
DOI : 10.1002/glia.1101

A. Al-araji and D. Kidd, Neuro-Beh??et's disease: epidemiology, clinical characteristics, and management, The Lancet Neurology, vol.8, issue.2, pp.192-204, 2009.
DOI : 10.1016/S1474-4422(09)70015-8

P. Sfikakis, Behcet's disease: a new target for anti-tumour necrosis factor treatment, Annals of the Rheumatic Diseases, vol.61, issue.Supplement 2, pp.51-53, 2002.
DOI : 10.1136/ard.61.suppl_2.ii51

J. Lee, P. Wang, M. Kattah, S. Youssef, L. Steinman et al., Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells, The Journal of Immunology, vol.181, issue.9, pp.6536-6581, 2008.
DOI : 10.4049/jimmunol.181.9.6536

A. Isaacs and J. Lindenmann, Virus Interference. I. The Interferon, Proceedings of the Royal Society B: Biological Sciences, vol.147, issue.927, pp.258-267, 1957.
DOI : 10.1098/rspb.1957.0048

E. Borden, G. Sen, G. Uze, R. Silverman, R. Ransohoff et al., Interferons at age 50: past, current and future impact on biomedicine, Nature Reviews Drug Discovery, vol.56, issue.12, pp.975-990, 2007.
DOI : 10.1038/nrd2422

URL : https://hal.archives-ouvertes.fr/hal-00203077

T. Asselah and P. Marcellin, New direct-acting antivirals' combination for the treatment of chronic hepatitis C, Liver International, vol.376, pp.68-77, 2011.
DOI : 10.1111/j.1478-3231.2010.02411.x

G. Trinchieri, Type I interferon: friend or foe?, The Journal of Experimental Medicine, vol.5, issue.10, pp.2053-2063, 2010.
DOI : 10.1002/hep.21970

A. Theofilopoulos, R. Baccala, B. Beutler, and D. Kono, TYPE I INTERFERONS (??/??) IN IMMUNITY AND AUTOIMMUNITY, Annual Review of Immunology, vol.23, issue.1, pp.307-336, 2005.
DOI : 10.1146/annurev.immunol.23.021704.115843

M. De-veer, M. Holko, M. Frevel, E. Walker, S. Der et al., Functional classification of interferon-stimulated genes identified using microarrays, J Leukoc Biol, vol.69, pp.912-920, 2001.

J. Schoggins, S. Wilson, M. Panis, M. Murphy, C. Jones et al., A diverse range of gene products are effectors of the type I interferon antiviral response, Nature, vol.81, issue.7344, pp.481-485, 2011.
DOI : 10.1038/nature09907

K. Helbig, D. Lau, L. Semendric, and H. Harley, Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector, Hepatology, vol.101, issue.3, pp.702-710, 2005.
DOI : 10.1002/hep.20844

L. Brodsky, A. Wahed, . Lij, J. Tavis, T. Tsukahara et al., A Novel Unsupervised Method to Identify Genes Important in the Anti-viral Response: Application to Interferon/Ribavirin in Hepatitis C Patients, PLoS ONE, vol.26, issue.7, p.584, 2007.
DOI : 10.1371/journal.pone.0000584.s001

T. Asselah, I. Bièche, S. Narguet, A. Sabbagh, I. Laurendeau et al., Gene expression and hepatitis C virus infection, Gut, vol.58, issue.6, pp.846-858, 2008.
DOI : 10.1136/gut.2008.166348

M. Sarasin-filipowicz, E. Oakeley, F. Duong, V. Christen, L. Terracciano et al., Interferon signaling and treatment outcome in chronic hepatitis C, Proceedings of the National Academy of Sciences, vol.105, issue.19, pp.7034-7039, 2008.
DOI : 10.1073/pnas.0707882105

T. Asselah, I. Bieche, and S. Narguet, Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C, Gut, vol.57, issue.4, pp.516-524, 2008.
DOI : 10.1136/gut.2007.128611

E. Foy, K. Li, C. Wang, R. Sumpter-jr, M. Ikeda et al., Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease, Science, vol.300, issue.5622, pp.1145-1148, 2003.
DOI : 10.1126/science.1082604

R. 1. Burke, D. Isaacs, A. Walker, and J. , The nucleic acid content of influenza virus, Biochimica et Biophysica Acta, vol.26, issue.3, pp.576-584, 1957.
DOI : 10.1016/0006-3002(57)90105-1

A. Isaacs and J. Lindenmann, Virus Interference. I. The Interferon, Proceedings of the Royal Society B: Biological Sciences, vol.147, issue.927, pp.258-267, 1957.
DOI : 10.1098/rspb.1957.0048

A. Isaacs, J. Lindenmann, and R. Valentine, Virus Interference. II. Some Properties of Interferon, Proceedings of the Royal Society B: Biological Sciences, vol.147, issue.927, pp.268-273, 1957.
DOI : 10.1098/rspb.1957.0049

J. Lindenmann, D. Burke, and A. Isaacs, Studies on the production, mode of action and properties of interferon, Br J Exp Pathol, vol.38, pp.551-562, 1957.

D. Burke and A. Isaacs, Further studies on interferon, Br J Exp Pathol, vol.39, pp.78-84, 1958.

A. Isaacs and D. Burke, Mode of Action of Interferon, Nature, vol.5, issue.4642, pp.1073-1074, 1958.
DOI : 10.1038/1821073a0

A. Isaacs, D. Burke, and L. Fadeeva, Effect of interferon on the growth of viruses on the chick chorion, Br J Exp Pathol, vol.39, pp.447-451, 1958.

D. Burke and A. Isaacs, Some factors affecting the production of interferon, Br J Exp Pathol, vol.39, pp.452-458, 1958.

A. Isaacs and D. Burke, Interferon: a possible check to virus infections. The New Scientist, 1958.

D. Burke, The purification of interferon, Biochemical Journal, vol.78, issue.3, pp.556-564, 1961.
DOI : 10.1042/bj0780556

*. Vassili, !for!these!three!exceptional!years!of!discussion,!integration,!science,!bullshit!and! greek!music

. Amigorena, !for!accepting!me!as!PhD!student,! for!their! help!and!scientifically!enriching! exchanges

*. Theeli, . Cristina, . Rafa, and . Sophia, !past,!present!and!future

*. The, Cytometry!Platform!for!all!sorts,!the!discussion,!their!help,!and!their!cookies

*. Fadi and . David, Laplaud!for!the!new!collaboration