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!Les!protéines!Elmo!régulent!la!fonction!des!protéines!Dock!(Downstream!of!Crk),!qui!sont!des! Facteurs! d'Echange! de! Guanine! (GEF)! atypiques! pour! les! GTPases! Rac1! et! Cdc42 ,
! Toutefois,! la! présence! de! cette! région! conduit! à! ,
!form!a!conserved!regulatory!family! that!plays!a!central!role!in!a!number!of!processes!that!depend!on!actin!cytoskeleton!remodeling,!such!as! phagocytosis! and! cell! migration.! Elmo! proteins! regulate! the! function! of! Dock! proteins! (Downstream! of! CrK),!a!new!family!of!atypical!guanine!exchange!factors!(GEF)!for!Rac1!and!Cdc42!GTPases.!The!regulation! of!this!mechanism!is!based!on!the!interaction!between!the!200!CPterminal!residues!of!Elmo!and!the!180!NP terminal! residues! of! Dock.! However,! the! precise! role! of! the! different! domains! and! motifs! identified! in! these!regions!is!still!not!well!defined.!Indeed,!functional,!structural!and!biochemical!data! ,
! interaction! between! Elmo1! and! the! SH3! domain! of! Dock1! using! surface! plasmon! resonance.! Our! data! demonstrate! the! ability! of! the! SH3! domain! of! Dock1! to! interact! with! Elmo1! independently! of! the! CP terminal!polyproline!containing!region.!However,!the!presence!of!this!region!induces!a!significant!increase! in! the! halfPlife! of! the! Elmo1the!first!lowPresolution!model!of!Elmo1!in!which!we!can!locate!N!and!CP terminal! regions.! Surprisingly,! this! study! suggests! a! conformational! change! of! the! NPterminal! region, Dock1! complex.! In! parallel ,