Skip to Main content Skip to Navigation
New interface
Theses

Modulation de l’apport en acides gras polyinsaturés n-3 : intérêt chez le sujet sain et au cours de l’insuffisance rénale chronique

Abstract : Omega 3 fatty acids play an important modulatory role in metabolic and inflammatory responses, the progression of atherosclerosis and gene expression. Recent studies suggest their beneficial impact on adipocyte morphology and function. Chronic kidney disease (CKD) patients have an increased cardiovascular morbi-mortality and suffer from a cluster of metabolic disorders. On the basis of previous studies there are reasons to suggest that omega 3 supplementation may offer a host of benefits to CKD patients. Unfortunatly, published studies on the effect of such supplementation are characterized by supra physiological omega 3 doses, that may be difficult to implement for extended periods in one hand and in the other hand the metabolic effect of different doses of omega 3 hasn’t been studied in detail. Simple dietary modifications can help achieve the recommended n-6/n-3 ratio in healthy subjects. In CKD patients supplementation with n-3 shows a differential dose response effect. Further studies are required to test the faisability and metabolic impact of dietary modifications in order to decrease n-6/n-3 ratio and to assess the long term effect of omega supplementation in CKD patients. Finally the molecular pathways implicated in this differential dose response should be assessed in animal models
Document type :
Theses
Complete list of metadata

Cited literature [154 references]  Display  Hide  Download

https://theses.hal.science/tel-00903384
Contributor : ABES STAR :  Contact
Submitted on : Tuesday, November 12, 2013 - 10:12:07 AM
Last modification on : Tuesday, October 18, 2022 - 4:20:26 AM
Long-term archiving on: : Thursday, February 13, 2014 - 4:22:35 AM

File

TH2010_Guebre-Egziabher_Fitsum...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00903384, version 1
  • PRODINRA : 330159

Citation

Fitsum Guebre-Egziabher. Modulation de l’apport en acides gras polyinsaturés n-3 : intérêt chez le sujet sain et au cours de l’insuffisance rénale chronique. Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2010. Français. ⟨NNT : 2010LYO10126⟩. ⟨tel-00903384⟩

Share

Metrics

Record views

498

Files downloads

577