Skip to Main content Skip to Navigation
New interface
Theses

Implication de l’Insulin-like Growth Factor (IGF-I), secrété par le microenvironnement tumoral, dans la survie et la chimiorésistance des cellules cancéreuses

Abstract : The microenvironment, composed of several cellular elements and extracellular matrix, plays an important role in tumor development and metastasis. Thus, the study of these interactions is important for cell targeted therapies fighting against chemoresistant tumor cells. This thesis aims to investigate the role of growth factor IGF-I in the chemoresistance of ovarian cancer cells and myeloid leukemia, present in the microenvironment.As a first step, we demonstrated that drug resistance of ovarian cancer cells gained by host cells (hospicells) is related to the secretion of IGF-I by these cells. We have also demonstrated that IGF-I is involved in the regulation of genes ABC (MDR-1, MRP1, MRP2, and BCRP) via STAT3, Jak2, PI3K et ERK signaling pathways.In myeloid leukemia, we have shown that IGF-I has an effect on cell proliferation. It induces the expression of P-gp protein and chemoresistance of cells sensitive to chemotherapy. We also determined the role of IGF-I in the resistance of leukemic cells in the presence of hospicells. These cells have an in vivo hyperangiogenic activity, related to HIF-1 and VEGF, and inhibit immune responses of T cells by NO production.We determined the crucial role of MMP-9 in resistant cells migration of breast cancer expressing P-gp protein and in the formation of a tubular network, suggesting a link between the expression of P-gp and MMP-9.
Document type :
Theses
Complete list of metadata

https://theses.hal.science/tel-00921852
Contributor : ABES STAR :  Contact
Submitted on : Friday, April 18, 2014 - 11:43:11 AM
Last modification on : Sunday, June 26, 2022 - 5:24:53 AM
Long-term archiving on: : Monday, April 10, 2017 - 3:38:29 PM

File

VA-BENABBOU-Nadia-211212.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00921852, version 1

Citation

Nadia Benabbou. Implication de l’Insulin-like Growth Factor (IGF-I), secrété par le microenvironnement tumoral, dans la survie et la chimiorésistance des cellules cancéreuses. Médecine humaine et pathologie. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA11T100⟩. ⟨tel-00921852⟩

Share

Metrics

Record views

337

Files downloads

1871