N. Lecat-guillet and Y. Ambroise, ]thiazole in Sodium/Iodide Symporter (NIS)-Expressing Cells, ChemMedChem, vol.77, issue.8, pp.1211-1216, 2008.
DOI : 10.1002/cmdc.200800052

N. Lecat-guillet and Y. Ambroise, ]thiazoles as Iodide Efflux Inhibitors in Thyrocytes, ChemMedChem, vol.5, issue.11, pp.1819-1830, 2009.
DOI : 10.1002/cmdc.200900365

M. Anbar, S. Guttmann, and Z. Lewitus, Effect of Monofluorosulphonate, Difluorophosphate and Fluoroborate Ions on the Iodine Uptake of the Thyroid Gland, Nature, vol.38, issue.4674, pp.1517-1518, 1959.
DOI : 10.1038/1831517a0

N. Lecat-guillet, Identification d'inhibiteurs du symporteur iode/sodium par criblage à haut-débit, Biochim. Biophys. Acta, vol.1154, pp.65-82, 1993.

S. Kaminsky, O. Levy, M. Garry, and N. Carrasco, Inhibition of the Na+/I- symporter by harmaline and 3-amino-1-methyl-5H-pyrido(4,3-b)indole acetate in thyroid cells and membrane vesicles, European Journal of Biochemistry, vol.56, issue.1, pp.203-207, 1991.
DOI : 10.1111/j.1432-1033.1991.tb21068.x

T. Kosuge, K. Tsuji, K. Wakabayashi, T. Okamoto, K. Shudo et al., Isolation and structure studies of mutagenic principles in amino acid pyrolysates., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.26, issue.2, pp.611-619, 1978.
DOI : 10.1248/cpb.26.611

N. Lecat-guillet, G. Merer, R. Lopez, T. Pourcher, B. Rousseau et al., Small-Molecule Inhibitors of Sodium Iodide Symporter Function, ChemBioChem, vol.267, issue.6, pp.889-895, 2008.
DOI : 10.1002/cbic.200700682

F. Waltz, L. Pillette, E. Verhaege, and Y. Ambroise, Synthesis and Structure-Activity Relationships of a Class of Sodium Iodide Symporter Function Inhibitors, ChemMedChem, vol.396, issue.10, pp.1775-1777, 2011.
DOI : 10.1002/cmdc.201100258

N. Lecat-guillet and Y. Ambroise, Discovery of Aryltrifluoroborates as Potent Sodium/Iodide Symporter (NIS) Inhibitors, ChemMedChem, vol.68, issue.3, pp.1207-1209, 2008.
DOI : 10.1002/cmdc.200800049

F. Sweet and J. Fissekis, Synthesis of 3,4-dihydro-2(1H)-pyrimidinones and the mechanism of the Biginelli reaction, Journal of the American Chemical Society, vol.95, issue.26, pp.8741-8749, 1973.
DOI : 10.1021/ja00807a040

E. Hu, D. Sidler, and U. Dolling, Unprecedented Catalytic Three Component One-Pot Condensation Reaction:?? An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones, The Journal of Organic Chemistry, vol.63, issue.10, pp.3454-3457, 1998.
DOI : 10.1021/jo970846u

M. Litvi?, I. Ve?enaj, Z. Ladi?i?, M. Lovri?, V. Vinkovi? et al., First application of hexaaquaaluminium(III) tetrafluoroborate as a mild, recyclable, non-hygroscopic acid catalyst in organic synthesis: a simple and efficient protocol for the multigram scale synthesis of 3,4-dihydropyrimidinones by Biginelli reaction, Tetrahedron, vol.66, issue.19, pp.3463-3471, 2010.
DOI : 10.1016/j.tet.2010.03.024

E. Hu, D. Sidler, and U. Dolling, Unprecedented Catalytic Three Component One-Pot Condensation Reaction:?? An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones, The Journal of Organic Chemistry, vol.63, issue.10, pp.3454-3457, 1998.
DOI : 10.1021/jo970846u

B. Jauk, T. Pernat, and C. Kappe, Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926, Molecules, vol.5, issue.3, pp.227-239, 2000.
DOI : 10.3390/50300227

K. Folkers, H. Harwood, and T. Johnson, RESEARCHES ON PYRIMIDINES. CXXX. SYNTHESIS OF 2-KETO-1,2,3,4-TETRAHYDROPYRIMIDINES, Journal of the American Chemical Society, vol.54, issue.9, pp.3751-3758, 1932.
DOI : 10.1021/ja01348a040

D. Bose, L. Fatima, and H. Mereyala, )-ones by a Three-Component Coupling of One-Pot Condensation Reaction:?? Comparison of Ethanol, Water, and Solvent-free Conditions, The Journal of Organic Chemistry, vol.68, issue.2, pp.587-590, 2003.
DOI : 10.1021/jo0205199

Y. Ma, C. Qian, L. Wang, and M. Yang, Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions, The Journal of Organic Chemistry, vol.65, issue.12, pp.3864-3868, 2000.
DOI : 10.1021/jo9919052

B. Ranu, A. Hajra, and S. Dey, A Practical and Green Approach towards Synthesis of Dihydropyrimidinones without Any Solvent or Catalyst, Organic Process Research & Development, vol.6, issue.6, pp.817-818, 2002.
DOI : 10.1021/op0255478

M. Kolosov, V. Orlov, D. Belobodorov, and V. Dotsenko, A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis, Molecular Diversity, vol.27, issue.3, pp.5-25, 2009.
DOI : 10.1007/s11030-008-9094-8

C. Kappe and C. , 4 « Biginelli reaction », in Multicomponent reactions by, pp.3-527, 2005.

L. Pisani, H. Prokopcova, J. Kremsner, and C. Kappe, 5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques, Journal of Combinatorial Chemistry, vol.9, issue.3, pp.415-421, 2007.
DOI : 10.1021/cc0700041

M. Matloobi and C. Kappe, Microwave-Assisted Solution- and Solid-Phase Synthesis of 2-Amino-4-arylpyrimidine Derivatives, Journal of Combinatorial Chemistry, vol.9, issue.2, pp.275-284, 2007.
DOI : 10.1021/cc0601377

B. Desai, D. Dallinger, and C. Kappe, Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters, Tetrahedron, vol.62, issue.19, pp.4651-4664, 2006.
DOI : 10.1016/j.tet.2005.12.061

Y. Wang, H. Yang, Y. J. Miao, Z. Chen, and R. , Highly Enantioselective Biginelli Reaction Promoted by Chiral Bifunctional Primary Amine-Thiourea Catalysts: Asymmetric Synthesis of Dihydropyrimidines, Advanced Synthesis & Catalysis, vol.43, issue.18, pp.3057-3061, 2009.
DOI : 10.1002/adsc.200900597

X. Chen, X. Xu, H. Liu, L. Cun, and L. Gong, Highly Enantioselective Organocatalytic Biginelli Reaction, Journal of the American Chemical Society, vol.128, issue.46, pp.14802-14803, 2006.
DOI : 10.1021/ja065267y

Y. Huang and Y. F. Zhu, Highly Enantioseletive Biginelli Reaction Using a New Chiral Ytterbium Catalyst:?? Asymmetric Synthesis of Dihydropyrimidines, Journal of the American Chemical Society, vol.127, issue.47, pp.16386-16387, 2005.
DOI : 10.1021/ja056092f

A. Dondoni and A. Massi, Decoration of dihydropyrimidine and dihydropyridine scaffolds with sugars via Biginelli and Hantzsch multicomponent reactions: An efficient entry to a collection of artificial nucleosides, Molecular Diversity, vol.6, issue.3/4, pp.261-270, 2003.
DOI : 10.1023/B:MODI.0000006806.91483.a3

R. Milcent, J. Malanda, and G. Barbier, ]pyrimidines, Journal of Heterocyclic Chemistry, vol.FV, issue.1, pp.329-336, 1997.
DOI : 10.1002/jhet.5570340152

J. Vanden-eynde, N. Hecq, O. Kataeva, and K. C. , Microwave-mediated regioselective synthesis of novel pyrimido[1,2-a]pyrimidines under solvent-free conditions, Tetrahedron, vol.57, issue.9, pp.1785-1791, 2001.
DOI : 10.1016/S0040-4020(00)01157-1

B. Nilsson and L. E. Overman, Concise Synthesis of Guanidine-Containing Heterocycles Using the Biginelli Reaction, The Journal of Organic Chemistry, vol.71, issue.20, pp.7706-7714, 2006.
DOI : 10.1021/jo061199m

K. Atwal, G. C. Rovnyak, B. C. O-'reilly, and J. Schwartz, Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines, The Journal of Organic Chemistry, vol.54, issue.25, pp.5898-5907, 1989.
DOI : 10.1021/jo00286a020

T. Mayer, T. Kapoor, S. Haggarty, R. King, S. Schreiber et al., Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen, Science, vol.286, issue.5441, pp.971-974, 1999.
DOI : 10.1126/science.286.5441.971

D. Nagarathnam, S. Miao, B. Lagu, G. Chiu, J. Fang et al., Adrenoceptor-Selective Antagonists. 1. Structure???Activity Relationship in Dihydropyrimidinones, Journal of Medicinal Chemistry, vol.42, issue.23, pp.4764-4777, 1995.
DOI : 10.1021/jm990200p

A. Patil, N. Kumar, W. Kokke, M. Bean, A. Freyer et al., Novel Alkaloids from the Sponge Batzella sp.: Inhibitors of HIV gp120-Human CD4 Binding, The Journal of Organic Chemistry, vol.60, issue.5, pp.1182-1188, 1995.
DOI : 10.1021/jo00110a021

M. Lögers, L. Overman, and G. Welmaker, Mannich Biscyclizations. Total Synthesis of (-)-Ajmalicine, Journal of the American Chemical Society, vol.117, issue.36, p.9139, 1995.
DOI : 10.1021/ja00141a004

B. Maryanoff, H. Zhang, J. Cohen, I. Turchi, and C. Maryanoff, -Acyliminium Ions, Chemical Reviews, vol.104, issue.3, pp.1431-1628, 2004.
DOI : 10.1021/cr0306182

H. Yamada, T. Kawate, M. Matsumizu, A. Nishida, K. Yamaguchi et al., -Hydroxytryptamine with Aldehydes, The Journal of Organic Chemistry, vol.63, issue.18, pp.6348-6354, 1998.
DOI : 10.1021/jo980810h

URL : https://hal.archives-ouvertes.fr/in2p3-00459276

J. Seayad, A. Seayad, and B. List, Catalytic Asymmetric Pictet???Spengler Reaction, Journal of the American Chemical Society, vol.128, issue.4, pp.1086-1087, 2005.
DOI : 10.1021/ja057444l

URL : http://hdl.handle.net/11858/00-001M-0000-0014-A470-9

F. Bou-hamdan and J. Leighton, Highly Enantioselective Pictet-Spengler Reactions with ??-Ketoamide-Derived Ketimines: Access to an Unusual Class of Quaternary ??-Amino Amides, Angewandte Chemie International Edition, vol.9, issue.13, pp.2403-2406, 2009.
DOI : 10.1002/anie.200806110

G. Schmidt, H. Waldmann, H. Henke, and M. Burkard, Asymmetric Control in the Pictet???Spengler Reaction by Means ofN-Protected Amino Acids as Chiral Auxiliary Groups, Chemistry - A European Journal, vol.57, issue.12, pp.1566-1571, 1996.
DOI : 10.1002/chem.19960021215

E. Cox and J. Cook, The Pictet-Spengler condensation: a new direction for an old reaction, Chemical Reviews, vol.95, issue.6, pp.1797-1842, 1995.
DOI : 10.1021/cr00038a004

P. Roszkowski, S. Czarnocki, J. Maurin, A. Siwicka, A. Sawadzka et al., Variety of natural products derived from tryptophan and stereoselective synthesis of tetrahydro-??-carboline derivatives of pharmacological importance, International Congress Series, vol.1304, pp.46-59, 2007.
DOI : 10.1016/j.ics.2007.07.003

T. Herraiz, J. Galisteo, and J. , Tetrahydro-??-carboline Alkaloids Occur in Fruits and Fruit Juices. Activity as Antioxidants and Radical Scavengers, Journal of Agricultural and Food Chemistry, vol.51, issue.24, pp.7156-7161, 2003.
DOI : 10.1021/jf030324h

F. Waltz and «. , Etude du transport de l'iode par chémogénomique, p.142, 2011.

M. Harding, A. Galat, D. Uehling, and S. Schreiber, A receptor for the immuno-suppressant FK506 is a cis???trans peptidyl-prolyl isomerase, Nature, vol.341, issue.6244, pp.758-760, 1989.
DOI : 10.1038/341758a0

S. Bach, M. Knockaert, J. Reinhardt, O. Lozach, S. Schmitt et al., Roscovitine Targets, Protein Kinases and Pyridoxal Kinase, Journal of Biological Chemistry, vol.280, issue.35, pp.31208-31219, 2005.
DOI : 10.1074/jbc.M500806200

URL : https://hal.archives-ouvertes.fr/hal-00018751

S. Sato, Y. Kwon, S. Kamisuki, N. Srivastava, Q. Mao et al., Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules:?? Isolation of a New Target of Indomethacin, Journal of the American Chemical Society, vol.129, issue.4, pp.873-880, 2007.
DOI : 10.1021/ja0655643

L. Burdine and T. Kodadek, Target Identification in Chemical Genetics, Chemistry & Biology, vol.11, issue.5, pp.593-597, 2004.
DOI : 10.1016/j.chembiol.2004.05.001

M. Reddy, K. Bachhawat-sikder, and T. Kodadek, Transformation of Low-Affinity Lead Compounds into High-Affinity Protein Capture Agents, Chemistry & Biology, vol.11, issue.8, pp.1127-1137, 2004.
DOI : 10.1016/j.chembiol.2004.05.013

Y. Hatanaka and Y. Sadakane, Photoaffinity Labeling in Drug Discovery and Developments: Chemical Gateway for Entering Proteomic Frontier, Current Topics in Medicinal Chemistry, vol.2, issue.3, pp.271-288, 2002.
DOI : 10.2174/1568026023394182

E. Verhaege and «. , Etude des mécanismes d'accumulation de l'iode chez l'algue brune Laminaria Digitata et chez les mammifères, p.151, 2007.

F. Kotzyba-hibert, I. Kapfer, and M. Goeldner, Recent Trends in Photoaffinity Labeling, Angewandte Chemie International Edition in English, vol.34, issue.12, pp.1296-1312, 1995.
DOI : 10.1002/anie.199512961

N. Lecat-guillet, G. Merer, R. Lopez, T. Pourcher, B. Rousseau et al., Small-Molecule Inhibitors of Sodium Iodide Symporter Function, ChemBioChem, vol.267, issue.6, pp.889-895, 2008.
DOI : 10.1002/cbic.200700682

L. Pisani, H. Prokopcova, J. Kremsner, and C. Kappe, 5-Aroyl-3,4-dihydropyrimidin-2-one Library Generation via Automated Sequential and Parallel Microwave-assisted Synthesis Techniques, Journal of Combinatorial Chemistry, vol.9, issue.3, pp.415-421, 2007.
DOI : 10.1021/cc0700041

B. Ranu, A. Hajra, and J. U. , Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction, The Journal of Organic Chemistry, vol.65, issue.19, pp.6270-6272, 2000.
DOI : 10.1021/jo000711f

E. Hu, D. Sidler, and U. Dolling, Unprecedented Catalytic Three Component One-Pot Condensation Reaction:?? An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones, The Journal of Organic Chemistry, vol.63, issue.10, pp.3454-3457, 1998.
DOI : 10.1021/jo970846u

B. Desai, D. Dallinger, and C. Kappe, Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters, Tetrahedron, vol.62, issue.19, p.4651, 2006.
DOI : 10.1016/j.tet.2005.12.061

Y. Ma, C. Qian, L. Wang, and M. Yang, Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions, The Journal of Organic Chemistry, vol.65, issue.12, pp.3864-3868, 2000.
DOI : 10.1021/jo9919052

K. Kai, A. Tani, and H. Hayashi, Facile preparation of deuterium-labeled N-acylhomoserine lactones as internal standards for isotope dilution mass spectrometry, Bioorganic & Medicinal Chemistry, vol.18, issue.11, pp.3776-3782, 2010.
DOI : 10.1016/j.bmc.2010.04.055

G. Dai, O. Levy, L. Amzel, N. Carrasco, and C. , Chapter 15 The mediator of thyroidal iodide accumulation: The sodium/iodide symporter, Handbook of Biological Physics, 1996.
DOI : 10.1016/S1383-8121(96)80056-X

F. Waltz, L. Pillette, and Y. Ambroise, A nonradioactive iodide uptake assay for sodium iodide symporter function, Analytical Biochemistry, vol.396, issue.1, pp.91-95, 2010.
DOI : 10.1016/j.ab.2009.08.038

N. Lecat-guillet, G. Merer, R. Lopez, T. Pourcher, B. Rousseau et al., A 96-Well Automated Radioiodide Uptake Assay for Sodium/Iodide Symporter Inhibitors, ASSAY and Drug Development Technologies, vol.5, issue.4, pp.535-540, 2007.
DOI : 10.1089/adt.2007.068

E. Sandell and I. Kolthoff, CHRONOMETRIC CATALYTIC METHOD FOR THE DETERMINATION OF MICRO QUANTITIES OF IODINE, Journal of the American Chemical Society, vol.56, issue.6, pp.1426-1426, 1934.
DOI : 10.1021/ja01321a510

M. Lima, L. Barreiro, and E. , Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design, Current Medicinal Chemistry, vol.12, issue.1, pp.23-49, 2005.
DOI : 10.2174/0929867053363540

W. Krenn, P. Verdino, G. Uray, K. Faber, and C. Kappe, Determination of absolute configuration in 4-aryl-3,4-dihydro-2(1H)-pyrimidones by high performance liquid chromatography and CD spectroscopy, Chirality, vol.15, issue.8, pp.659-662, 1999.
DOI : 10.1002/(SICI)1520-636X(1999)11:8<659::AID-CHIR8>3.0.CO;2-V

C. Kappe, Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog, Accounts of Chemical Research, vol.33, issue.12, pp.879-888, 2000.
DOI : 10.1021/ar000048h

G. Uray, P. Verdino, F. Belaj, C. Kappe, and W. Fabian, )-pyrimidones:?? A Combined Theoretical and Experimental Investigation, The Journal of Organic Chemistry, vol.66, issue.20, pp.6685-6694, 2001.
DOI : 10.1021/jo010491l

C. Lipinski, F. Lombardo, B. Dominy, and P. Feeney, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Advanced Drug Delivery Reviews, vol.23, issue.1-3, pp.3-25, 1997.
DOI : 10.1016/S0169-409X(96)00423-1

W. Walters, M. Murcko, and A. , Prediction of ???drug-likeness???, Advanced Drug Delivery Reviews, vol.54, issue.3, pp.255-271, 2002.
DOI : 10.1016/S0169-409X(02)00003-0

D. Veber, S. Johnson, H. Cheng, B. Smith, K. Ward et al., Molecular Properties That Influence the Oral Bioavailability of Drug Candidates, Journal of Medicinal Chemistry, vol.45, issue.12, pp.2615-2623, 2002.
DOI : 10.1021/jm020017n

A. Ghose, V. Viswanadham, and J. Wendoloski, A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases, Journal of Combinatorial Chemistry, vol.1, issue.1, pp.55-68, 1999.
DOI : 10.1021/cc9800071

J. Delfino, S. Schreiber, and F. Richards, Design, synthesis, and properties of a photoactivatable membrane-spanning phospholipidic probe, Journal of the American Chemical Society, vol.115, issue.9, pp.3458-3474, 1993.
DOI : 10.1021/ja00062a009

T. Greene, Protective Groups in Organic Synthesis, 1999.
DOI : 10.1002/0471220574

P. Deslongchamps, Y. Dory, and S. Li, The Relative Rate of Hydrolysis of a Series of Acyclic and Six-Membered Cyclic Acetals, Ketals, Orthoesters, and Orthocarbonates, Tetrahedron, vol.56, issue.22, pp.3533-3537, 2000.
DOI : 10.1016/S0040-4020(00)00270-2

C. Kouklowski, Products Class 8 : 1,3-dioxanes, 1,3-dioxepanes and larger-ring O/O acetals, Science of Synthesis, vol.29, 2007.

V. Cirkva, S. Boehm, and P. Oldrich, Radical addition reactions of fluorinated species. Part 8. Regioselectivity of radical additions to perfluoroalkylethylenes and quantum chemical calculations. Highly selective two-step synthesis of 4-(perfluoroalkyl)butane-1,2-diols, Journal of Fluorine Chemistry, vol.102, issue.1-2, pp.159-168, 2000.
DOI : 10.1016/S0022-1139(99)00237-7

B. Khanetskyy, D. Dallinger, and C. Kappe, Combining Biginelli Multicomponent and Click Chemistry:?? Generation of 6-(1,2,3-Triazol-1-yl)-Dihydropyrimidone Libraries, Journal of Combinatorial Chemistry, vol.6, issue.6, pp.884-892, 2004.
DOI : 10.1021/cc0498938

R. Sulake, C. Chen, H. Lin, and A. Lua, Synthesis of deuterium labeled ketamine metabolite dehydronorketamine-d4, Bioorganic & Medicinal Chemistry Letters, vol.21, issue.19, pp.5719-5721, 2011.
DOI : 10.1016/j.bmcl.2011.08.021

F. Waltz and «. , Etude du transport de l'iode par chémogénomique, 2011.

N. Lecat-guillet, G. Merer, R. Lopez, T. Pourcher, B. Rousseau et al., Small-Molecule Inhibitors of Sodium Iodide Symporter Function, ChemBioChem, vol.267, issue.6, pp.889-895, 2008.
DOI : 10.1002/cbic.200700682

E. Verhaeghe, Etude des mécanismes d'accumulation de l'iode chez l'algue brune Laminaria Digitata et chez les mammifères, 2007.

F. Waltz, Etude du transport de l'iode par chémogénomique, 2011.

T. Yamashita, N. Kawai, H. Tokuyama, T. Fukuyama, and J. , Stereocontrolled Total Synthesis of (???)-Eudistomin C, Journal of the American Chemical Society, vol.127, issue.43, pp.15038-15039, 2005.
DOI : 10.1021/ja055832h

N. Tamayo, Y. Bo, V. Gore, V. Ma, N. Nishimura et al., Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists, Journal of Medicinal Chemistry, vol.55, issue.4, pp.1593-1611, 2012.
DOI : 10.1021/jm2013634

M. Jayaraman, B. Fox, M. Hollingshead, G. Kohlhagen, Y. Pommier et al., ]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model, Journal of Medicinal Chemistry, vol.45, issue.1, pp.242-249, 2002.
DOI : 10.1021/jm000498f

R. Patil, S. Patil, X. Wang, F. Ma, W. Orr et al., Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents, Medicinal Chemistry Research, vol.46, issue.9, pp.131-137, 2011.
DOI : 10.1007/s00044-010-9356-8

B. Maryanoff, H. Zhang, J. Cohen, I. Turchi, and C. Maryanoff, -Acyliminium Ions, Chemical Reviews, vol.104, issue.3, pp.1431-1628, 2004.
DOI : 10.1021/cr0306182