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Recherche des assemblages moléculaires actifs en biolubrification en vue du diagnostic et de la thérapeutique précoce de pathologies articulaires

Abstract : Osteoarticular diseases account for approximately 10% of all diseases occurring inFrance each year. The difficulties in identifying their causes are also due to a deficiency inunderstanding the lubrication mechanism of healthy synovial joint.In this context, the first objective of the present study was to analyze the discontinuousstructure of synovial fluid samples from healthy animals and to reproduce it using commercialbiomolecular components in order to understand the lubrication mechanism in the healthycase. The second objective of this thesis was to analyze the evolution of the structure andthe lubricating properties of synovial fluid in the early stage of non-inflammatory andinflammatory diseases using pathological human fluid samples. In order to study moreprecisely the evolution of pathological lubrication this work aimed to develop lubricantmodels obtained from cell cultures of human synoviocytes adding the action of pathologicalinflammatory factors (cytokines). All together the results show the importance of the supramolecular structure of thesynovial fluid in obtaining good lubricating properties what may be a key parameter in theearly diagnosis of joint diseases and even more a chance to develop therapeutic fluids basedon nanostructured lubricants
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Constantin Ionut Matei. Recherche des assemblages moléculaires actifs en biolubrification en vue du diagnostic et de la thérapeutique précoce de pathologies articulaires. Autre [cond-mat.other]. Université Claude Bernard - Lyon I, 2012. Français. ⟨NNT : 2012LYO10334⟩. ⟨tel-00932693⟩

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