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Multi-modal characterisation of superparamagnetic iron oxide nanoparticles used as contrast agents in MRI of an ischemic stroke mouse model Activities: MRI of ischemic stroke mouse model, histology on ex-vivo mouse brain tissue, MR and TEM characterization of contrast agents; X-Ray imaging using synchrotron radiation University Diploma Animal experiments, level 1: Training course on animal models for biological and medical research and technologies for animal care and housing Option: Microstructure Imaging Coursework focusing on different microscopy techniques (confocal microscopy, scanning and transmission electron microscopy) for imaging micro and nanostructures; biological tissue preparation techniques for TEM visualization Internship work on: characterization by TEM of mouse spleen samples obtained at different time points after the administration of an iron oxide based MR contrast agent. The purpose was to monitor iron particles agglomeration and biotransformation in the spleen, 2003. ,
France Work on characterization by TEM of mouse aortic arch samples obtained at different time points after the administration of an iron oxide based MR contrast agent. The purpose was 2-folded: 1) to determine the nature of the atherosclerosis plaque and 2) to characterize iron particles inside inflammatory cells present in atherosclerosis lesions. Supervisor: PhD. Marie Genevieve Blanchin Diploma degree Atherosclerosis plaque characterization by MRI and TEM " SKILLS MRI high field, small animal imaging, quantitative image analysis, contrast agents, biomarker Transmission and Scanning Electron Microscopy Immunohistochemical analysis, 2012. ,