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Imagerie multi-spectrale par résonance des plasmons de surface : développement et applications

Abstract : Biodetection is at the core of the current health concerns, as shown through the variety of applications to HIV screening, food contaminant analysis or water quality monitoring. In this field, plasmonic biosensing is a well-established label-free technique on the market: commercial systems from HORIBA Scientific are currently available for both research and industrial users.Based on the surface plasmon resonance (SPR) phenomenon, plasmonic biodetection uses the high sensitivity of an evanescent wave propagating along a metallic film (forming the biochip) and the surrounding dielectric medium interface. More specifically, the adsorption of biomolecules onto the metal surface induces a strong change in the optical properties of a light beam reflected by the biochip: the main principle of plasmonic transduction consists in measuring these physical changes. Several interrogation techniques have therefore been developed to access such optical information, but they fail in meeting the most demanding user requirements for precise, real-time, high-throughput measurement.Initiated by these issues, the instrumentation work presented in this document has led to the development of a novel SPR interrogation technique, referred to as multi-spectral interrogation. Moreover, the promising results obtained have been pushed forward to propose a multi-spectral illumination system based on LEDs, providing attractive performances compared to existing configurations. The biosensing potential of the developed system, demonstrated through applications to genetic diagnosis and cancer detection, opens the door to a new generation of compact, high-performance, low-cost SPR sensors.
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https://theses.hal.science/tel-01127017
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Submitted on : Friday, March 6, 2015 - 11:29:13 PM
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  • HAL Id : tel-01127017, version 1

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Alexandra Sereda. Imagerie multi-spectrale par résonance des plasmons de surface : développement et applications. Autre [cond-mat.other]. Université Paris Sud - Paris XI, 2014. Français. ⟨NNT : 2014PA112321⟩. ⟨tel-01127017⟩

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