C. Blanpain and E. Fuchs, Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration, Science, vol.344, p.1242281, 2014.

C. Blanpain and B. D. Simons, Unravelling stem cell dynamics by lineage tracing, 2013.

, Nat Rev Mol Cell Biol, vol.14, pp.489-502

C. M. Blaumueller, H. Qi, P. Zagouras, A. , S. Bonnet et al., Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat Med, vol.90, pp.730-737, 1997.

S. J. Bray, Notch signalling: a simple pathway becomes complex, Nat Rev Mol Cell Biol, vol.7, pp.678-689, 2006.

S. J. Bray, Notch signalling in context, Nat Rev Mol Cell Biol, vol.17, pp.722-735, 2016.

K. Bruckner, L. Perez, H. Clausen, and S. Cohen, Glycosyltransferase activity of Fringe modulates Notch-Delta interactions, Nature, vol.406, pp.411-415, 2000.

R. A. Cavallo, R. T. Cox, M. M. Moline, J. Roose, G. A. Polevoy et al.,

A. Bejsovec, Drosophila Tcf and Groucho interact to repress Wingless signalling activity, Nature, vol.395, pp.604-608, 1998.

E. J. Formeister, A. L. Sionas, D. K. Lorance, C. L. Barkley, G. H. Lee et al., Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium, Am J Physiol Gastrointest Liver Physiol, vol.296, pp.1108-1118, 2009.

A. Foudi, K. Hochedlinger, D. Van-buren, J. W. Schindler, R. Jaenisch et al.,

H. Hock, Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells, 2009.

, Nat Biotechnol, vol.27, pp.84-90

X. Franch-marro, F. Wendler, J. Griffith, M. M. Maurice, and J. P. Vincent, In vivo role of lipid adducts on Wingless, J Cell Sci, vol.121, pp.1587-1592, 2008.

S. Fre, E. Hannezo, S. Sale, M. Huyghe, D. Lafkas et al.,

D. Louvard, A. , and S. , Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice, PLoS One, vol.6, 2011.

S. Fre, M. Huyghe, P. Mourikis, S. Robine, D. Louvard et al., Notch signals control the fate of immature progenitor cells in the intestine, Nature, vol.435, pp.964-968, 2005.

S. Fre, S. K. Pallavi, M. Huyghe, M. Lae, K. P. Janssen et al.,

S. , L. , and D. , Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine, Proc Natl Acad Sci U S A, vol.106, pp.6309-6314, 2009.

M. R. Howitt, S. Lavoie, M. Michaud, A. M. Blum, S. V. Tran et al.,

K. Redding, R. F. Margolskee, and L. C. Osborne, Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut, Science, vol.351, pp.1329-1333, 2016.

. , Population fact sheets: word, 2017.

H. Ireland, C. Houghton, L. Howard, and D. J. Winton, Cellular inheritance of a Creactivated reporter gene to determine Paneth cell longevity in the murine small intestine, Dev Dyn, vol.233, pp.1332-1336, 2005.

T. Iso, L. Kedes, and Y. Hamamori, HES and HERP families: multiple effectors of the Notch signaling pathway, J Cell Physiol, vol.194, pp.237-255, 2003.

N. Itasaki, C. M. Jones, S. Mercurio, A. Rowe, P. M. Domingos et al.,

R. , Wise, a context-dependent activator and inhibitor of Wnt signalling, Development, vol.130, pp.4295-4305, 2003.

V. Jaks, N. Barker, M. Kasper, J. H. Van-es, H. J. Snippert et al., Lgr5 marks cycling, yet long-lived, hair follicle stem cells, Nat Genet, vol.40, pp.1291-1299, 2008.

S. Jarriault, C. Brou, F. Logeat, E. H. Schroeter, R. Kopan et al., , 1995.

, Signalling downstream of activated mammalian Notch, Nature, vol.377, pp.355-358

E. H. Jho, T. Zhang, C. Domon, C. K. Joo, J. N. Freund et al., , 2002.

, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway, Mol Cell Biol, vol.22, pp.1172-1183

L. Jin, K. J. Hope, Q. Zhai, F. Smadja-joffe, D. et al., Targeting of CD44 eradicates human acute myeloid leukemic stem cells, Nat Med, vol.12, pp.1167-1174, 2006.

S. H. Johnston, C. Rauskolb, R. Wilson, B. Prabhakaran, K. D. Irvine et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch cell signature identifies colorectal cancer stem cells and predicts disease relapse, Cell Stem Cell, vol.8, pp.511-524, 1997.

C. A. Micchelli, E. J. Rulifson, and S. S. Blair, The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate, Development, vol.124, pp.1485-1495, 1997.

J. Milano, J. Mckay, C. Dagenais, L. Foster-brown, F. Pognan et al.,

A. Zacco, B. Greenberg, and P. J. Ciaccio, Modulation of notch processing by gammasecretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation, Toxicol Sci, vol.82, pp.341-358, 2004.

J. R. Miller, A. M. Hocking, J. D. Brown, and R. T. Moon, Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways, Oncogene, vol.18, pp.7860-7872, 1999.

D. J. Moloney, V. M. Panin, S. H. Johnston, J. Chen, L. Shao et al.,

P. Stanley, K. D. Irvine, and R. S. Haltiwanger, Fringe is a glycosyltransferase that modifies Notch, Nature, vol.406, pp.369-375, 2000.

R. K. Montgomery, D. L. Carlone, C. A. Richmond, L. Farilla, M. E. Kranendonk et al.,

D. E. Baffour-awuah, N. Y. Ambruzs, D. M. Fogli, L. K. Algra, and S. , Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells, Proc Natl Acad Sci, vol.328, pp.62-67, 2010.

Y. Nakanishi, H. Seno, A. Fukuoka, T. Ueo, Y. Yamaga et al.,

K. Kanda, H. Komekado, and M. Kawada, Dclk1 distinguishes between tumor and normal stem cells in the intestine, Nat Genet, vol.45, pp.98-103, 2013.

D. Nassar and C. Blanpain, Cancer Stem Cells: Basic Concepts and Therapeutic Implications, Annu Rev Pathol, vol.11, pp.47-76, 2016.
DOI : 10.1146/annurev-pathol-012615-044438

A. Niida, T. Hiroko, M. Kasai, Y. Furukawa, Y. Nakamura et al.,

T. Akiyama, DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway, Oncogene, vol.23, pp.8520-8526, 2004.

T. K. Noah and N. F. Shroyer, Notch in the intestine: regulation of homeostasis and pathogenesis, Annu Rev Physiol, vol.75, pp.263-288, 2013.

M. R. Novelli, J. A. Williamson, I. P. Tomlinson, G. Elia, S. V. Hodgson et al.,

W. F. Bodmer, W. , and N. A. , Polyclonal origin of colonic adenomas in an XO/XY patient with FAP, Science, vol.272, pp.1187-1190, 1996.

R. Nusse and H. E. Varmus, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome, Cell, vol.31, pp.99-109, 1982.

C. Nusslein-volhard and E. Wieschaus, Mutations affecting segment number and polarity in Drosophila, Nature, vol.287, pp.795-801, 1980.

C. A. O'brien, A. Pollett, S. Gallinger, D. , and J. E. , A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, vol.445, pp.106-110, 2007.

F. Oswald, M. Winkler, Y. Cao, K. Astrahantseff, S. Bourteele et al.,

T. Borggrefe, RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes, Mol Cell Biol, vol.25, pp.10379-10390, 2005.

M. Ousset, A. Van-keymeulen, G. Bouvencourt, N. Sharma, Y. Achouri et al., Multipotent and unipotent progenitors contribute to prostate postnatal development, Nat Cell Biol, vol.14, pp.1131-1138, 2012.
DOI : 10.1038/ncb2600

M. Ozawa, H. Baribault, and R. Kemler, The cytoplasmic domain of the cell, 1989.

, EMBO J, vol.8, pp.1711-1717

L. Pellegrinet, V. Rodilla, Z. Liu, S. Chen, U. Koch et al., Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells, Gastroenterology, vol.140, pp.1230-1240, 2011.

W. L. Perry, C. M. Hustad, D. A. Swing, T. N. O'sullivan, N. A. Jenkins et al., The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice, Nat Genet, vol.18, pp.143-146, 1998.

M. W. Pfaffl, A new mathematical model for relative quantification in real-time RTPCR, Nucleic Acids Res, vol.29, p.45, 2001.

K. I. Pinson, J. Brennan, S. Monkley, B. J. Avery, and W. C. Skarnes, An LDLreceptor-related protein mediates Wnt signalling in mice, Nature, vol.407, pp.535-538, 2000.

P. Polakis, Wnt signaling and cancer, Genes Dev, vol.14, pp.1837-1851, 2000.

F. Port, M. Kuster, P. Herr, E. Furger, C. Banziger et al., , 2008.

, Wingless secretion promotes and requires retromer-dependent cycling of Wntless, Nat Cell Biol, vol.10, pp.178-185

C. S. Potten, Stem cells in gastrointestinal epithelium: numbers, characteristics and death, Philos Trans R Soc Lond B Biol Sci, vol.353, pp.821-830, 1998.

C. S. Potten, C. Booth, G. L. Tudor, D. Booth, G. Brady et al.,

S. Sakakibara and H. Okano, Identification of a putative intestinal stem cell and early lineage marker; musashi-1, Differentiation, vol.71, pp.28-41, 2003.

C. S. Potten, L. Kovacs, H. , and E. , Continuous labelling studies on mouse skin and intestine, Cell Tissue Kinet, vol.7, pp.271-283, 1974.

C. S. Potten, G. Owen, and D. Booth, Intestinal stem cells protect their genome by selective segregation of template DNA strands, J Cell Sci, vol.115, pp.2381-2388, 2002.

J. D. Potter, Colorectal cancer: molecules and populations, J Natl Cancer Inst, vol.91, pp.916-932, 1999.

A. E. Powell, Y. Wang, Y. Li, E. J. Poulin, A. L. Means et al., The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor, Cell, vol.149, pp.146-158, 2012.

M. G. Prieve and M. L. Waterman, Nuclear localization and formation of beta, 1999.

, catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression, Mol Cell Biol, vol.19, pp.4503-4515

M. E. Prince, R. Sivanandan, A. Kaczorowski, G. T. Wolf, M. J. Kaplan et al.,

I. L. Weissman, M. F. Clarke, A. , and L. E. , Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma, Proc Natl Acad Sci U S A, vol.104, pp.973-978, 2007.

L. Qiu, C. Joazeiro, N. Fang, H. Y. Wang, C. Elly et al.,

Y. C. Liu, Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase, J Biol Chem, vol.275, pp.35734-35737, 2000.

M. Ramalho-santos and H. Willenbring, On the origin of the term "stem cell, Cell Stem Cell, vol.1, pp.35-38, 2007.

I. Rebay, R. J. Fleming, R. G. Fehon, L. Cherbas, P. Cherbas et al., Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor, Cell, vol.67, pp.687-699, 1991.

M. Reedijk, S. Odorcic, H. Zhang, R. Chetty, C. Tennert et al.,

S. Gallinger and S. E. Egan, Activation of Notch signaling in human colon adenocarcinoma, 2008.

, Int J Oncol, vol.33, pp.1223-1229

F. Reichsman, L. Smith, C. , and S. , Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction, J Cell Biol, vol.135, pp.819-827, 1996.

L. Ricci-vitiani, D. G. Lombardi, E. Pilozzi, M. Biffoni, M. Todaro et al.,

R. Maria, Identification and expansion of human colon-cancer-initiating cells, Nature, vol.445, pp.111-115, 2007.

O. Riccio, M. E. Van-gijn, A. C. Bezdek, L. Pellegrinet, J. H. Van-es et al.,

L. J. Strobl, T. Honjo, H. Clevers, R. , and F. , Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2, EMBO Rep, vol.9, pp.377-383, 2008.

F. Rijsewijk, L. Van-deemter, E. Wagenaar, A. Sonnenberg, N. et al., , 1987.

, Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity, EMBO J, vol.6, pp.127-131

V. Rodilla, A. Villanueva, A. Obrador-hevia, A. Robert-moreno, V. Fernandez-majada et al.,

W. J. Houdt, A. Pronk, J. Van-gorp, and P. D. Siersema, Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium, Gastroenterology, vol.141, pp.1762-1772, 2011.

T. Sato, J. H. Van-es, H. J. Snippert, D. E. Stange, R. G. Vries et al., Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts, Nature, vol.469, pp.415-418, 2011.

T. Sato, R. G. Vries, H. J. Snippert, M. Van-de-wetering, N. Barker et al., Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, vol.459, pp.262-265, 2009.

S. Satoh, Y. Daigo, Y. Furukawa, T. Kato, N. Miwa et al., AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1, Nat Genet, vol.24, pp.245-250, 2000.

J. Scharner and P. S. Zammit, The muscle satellite cell at 50: the formative years, 2011.

A. G. Schepers, H. J. Snippert, D. E. Stange, M. Van-den-born, J. H. Van-es et al.,

M. Wetering, C. , and H. , Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas, Science, vol.337, pp.730-735, 2012.

J. Schneikert and J. Behrens, The canonical Wnt signalling pathway and its APC partner in colon cancer development, Gut, vol.56, pp.417-425, 2007.

S. Schwitalla, A. A. Fingerle, P. Cammareri, T. Nebelsiek, S. I. Goktuna et al.,

O. Canli, J. Heijmans, D. J. Huels, and G. Moreaux, Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties, Cell, vol.152, pp.25-38, 2013.

S. Sell, Cellular origin of cancer: dedifferentiation or stem cell maturation arrest?, Environ Health Perspect, vol.101, issue.5, pp.15-26, 1993.

E. S. Seto, H. J. Bellen, L. , and T. E. , When cell biology meets development: endocytic regulation of signaling pathways, Genes Dev, vol.16, pp.1314-1336, 2002.

S. Shaheen, M. Ahmed, F. Lorenzi, and A. S. Nateri, Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer, Stem Cell Rev, vol.12, pp.492-499, 2016.

H. Sheldon, E. Heikamp, H. Turley, R. Dragovic, P. Thomas et al.,

M. Edelmann, B. Kessler, and R. C. Sainson, New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes, Blood, vol.116, pp.2385-2394, 2010.

K. Shimizu, S. Chiba, K. Kumano, N. Hosoya, T. Takahashi et al.,

Y. Yazaki and H. Hirai, Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods, J Biol Chem, vol.274, pp.32961-32969, 1999.

M. Shimokawa, Y. Ohta, S. Nishikori, M. Matano, A. Takano et al.,

S. Sugimoto, T. Kanai, and T. Sato, Visualization and targeting of LGR5+ human colon cancer stem cells, Nature, vol.545, pp.187-192, 2017.

S. K. Singh, C. Hawkins, I. D. Clarke, J. A. Squire, J. Bayani et al.,

M. D. Cusimano and P. B. Dirks, Identification of human brain tumour initiating cells, Nature, vol.432, pp.396-401, 2004.

M. H. Snow, Myogenic cell formation in regenerating rat skeletal muscle injured by mincing. II. An autoradiographic study, Anat Rec, vol.188, pp.201-217, 1977.

R. Song, B. K. Koo, K. J. Yoon, M. J. Yoon, K. W. Yoo et al., , 2006.

, J Biol Chem, vol.281, pp.36391-36400

M. S. Sosa, P. Bragado, and J. A. Aguirre-ghiso, Mechanisms of disseminated cancer cell dormancy: an awakening field, Nat Rev Cancer, vol.14, pp.611-622, 2014.

J. D. Starkey, M. Yamamoto, S. Yamamoto, and D. J. Goldhamer, Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates, J Histochem Cytochem, vol.59, pp.33-46, 2011.

S. R. Steele, E. K. Johnson, B. Champagne, B. Davis, S. Lee et al.,

D. A. Hayden and J. A. Maykel, Endoscopy and polyps-diagnostic and therapeutic advances in management, World J Gastroenterol, vol.19, pp.4277-4288, 2013.

A. Subramanian, P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert et al.,

A. Paulovich, S. L. Pomeroy, T. R. Golub, and E. S. Lander, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci U S A, vol.102, pp.15545-15550, 2005.

N. Takebe, L. Miele, P. J. Harris, W. Jeong, H. Bando et al., Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update, Nat Rev Clin Oncol, vol.12, pp.445-464, 2015.

N. Takeda, R. Jain, M. R. Leboeuf, Q. Wang, M. M. Lu et al., , 2011.

, Interconversion between intestinal stem cell populations in distinct niches, Science, vol.334, pp.1420-1424

K. Tamai, M. Semenov, Y. Kato, R. Spokony, C. Liu et al.,

J. P. Jeannet and X. He, LDL-receptor-related proteins in Wnt signal transduction, Nature, vol.407, pp.530-535, 2000.

D. G. Tang, Understanding cancer stem cell heterogeneity and plasticity, Cell Res, vol.22, pp.457-472, 2012.
DOI : 10.1038/cr.2012.13

URL : https://www.nature.com/articles/cr201213.pdf

P. W. Tetteh, O. Basak, H. F. Farin, K. Wiebrands, K. Kretzschmar et al.,

M. Born, J. Korving, F. De-sauvage, and J. H. Van-es, Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters, Cell Stem Cell, vol.18, pp.203-213, 2016.

R. Virchow, Virchows Arch. (Pathol. Anat. Physiol. Klin. Med. : Editorial), 1855.

J. E. Visvader, Cells of origin in cancer, Nature, vol.469, pp.314-322, 2011.

J. Von-moltke, M. Ji, H. E. Liang, and R. M. Locksley, Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit, Nature, vol.529, pp.221-225, 2016.

F. Walker, H. H. Zhang, A. Odorizzi, and A. W. Burgess, LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines, PLoS One, vol.6, p.22733, 2011.

Y. Wang and N. E. Navin, Advances and applications of single-cell sequencing technologies, Mol Cell, vol.58, pp.598-609, 2015.

B. E. Welm, S. B. Tepera, T. Venezia, T. A. Graubert, J. M. Rosen et al., Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population, Dev Biol, vol.245, pp.42-56, 2002.

N. R. West, S. Mccuaig, F. Franchini, P. , and F. , Emerging cytokine networks in colorectal cancer, Nat Rev Immunol, vol.15, pp.615-629, 2015.

K. A. Wharton, K. M. Johansen, T. Xu, A. , and S. , Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats, Cell, vol.43, pp.567-581, 1985.

P. M. Wigmore, S. Mustafa, M. El-beltagy, L. Lyons, J. Umka et al., , 2010.

, Effects of 5-FU, Adv Exp Med Biol, vol.678, pp.157-164

A. Wilson, E. Laurenti, G. Oser, R. C. Van-der-wath, W. Blanco-bose et al.,

S. Offner, C. F. Dunant, L. Eshkind, and E. Bockamp, Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair, Cell, vol.135, pp.1118-1129, 2008.

L. D. Wood, D. W. Parsons, S. Jones, J. Lin, T. Sjoblom et al., The genomic landscapes of human breast and colorectal cancers, Science, vol.318, pp.1108-1113, 2007.

A. Wuidart, M. Ousset, S. Rulands, B. D. Simons, A. Van-keymeulen et al., Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells, 2016.

, Genes Dev, vol.30, pp.1261-1277

T. P. Yamaguchi, Heads or tails: Wnts and anterior-posterior patterning, Curr Biol, vol.11, pp.713-724, 2001.

K. S. Yan, L. A. Chia, X. Li, A. Ootani, J. Su et al.,

M. R. Amieva, The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations, Proc Natl Acad Sci U S A, vol.109, pp.466-471, 2012.

H. Yanai, N. Atsumi, T. Tanaka, N. Nakamura, Y. Komai et al.,

K. Ishigaki, K. Saiga, and H. Ohsugi, Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine, J Biol Chem, vol.7, pp.33220-33227, 2004.

S. Zhang, C. Balch, M. W. Chan, H. C. Lai, D. Matei et al., Identification and characterization of ovarian cancer-initiating cells from primary human tumors, Cancer Res, vol.68, pp.4311-4320, 2008.

W. Zhou, R. Lv, W. Qi, D. Wu, Y. Xu et al., Snail contributes to the maintenance of stem cell-like phenotype cells in human pancreatic cancer, PLoS One, vol.9, p.87409, 2014.

L. Zhu, P. Gibson, D. S. Currle, Y. Tong, R. J. Richardson et al.,

S. Zakharenko, D. W. Ellison, and R. J. Gilbertson, Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation, Nature, vol.457, pp.603-607, 2009.

J. L. Ziskin, D. Dunlap, M. Yaylaoglu, I. K. Fodor, W. F. Forrest et al., In situ validation of an intestinal stem cell signature in colorectal cancer, Gut, vol.62, pp.1012-1023, 2013.