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Troubles cognitifs et émotionnels dans la maladie de Huntington : Etude chez les patients symptomatiques et présymptomatiques et chez des rats transgéniques, modèles de la maladie de Huntington.

Abstract : Huntington's disease (HD) is an autosomal dominant genetic neurodegenerative disease. HD is characterized by a combination of motor, cognitive, psychiatric and behavioral symptoms. Social cognition skills disorders have also been reported in these patients, including in particular recognition disorders of emotional facial expressions and theory of mind (ToM).Emotional functions and regulations are currently poorly characterized in patients and in animal models of HD. In patients, loss of emotional control, and negative or positive emotions recognition deficits have been described.In the rat model of HD (tgHD rats), disturbances of emotional and hedonic responses were characterized at early stage.The aim of this thesis was to better define the emotional deficits and their impact on executive functions (1) different cognitive tasks among HD patients and in animal models of HD (TgHD and BACHD rats) at different stages of the disease; (2) by analyzing the impact of induced emotional states (fear and pleasure) on decision making in symptomatic HD patients and in BACHD rats at different ages.
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https://theses.hal.science/tel-02288734
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Submitted on : Monday, September 16, 2019 - 1:06:32 AM
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  • HAL Id : tel-02288734, version 1

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Najia Toukdaoui. Troubles cognitifs et émotionnels dans la maladie de Huntington : Etude chez les patients symptomatiques et présymptomatiques et chez des rats transgéniques, modèles de la maladie de Huntington.. Sciences cognitives. Université Paris Saclay (COmUE), 2016. Français. ⟨NNT : 2016SACLS208⟩. ⟨tel-02288734⟩

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