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Potentiel thérapeutique des progeniteurs endothéliaux dans le traitement de la défaillance ventriculaire droite secondaire à l'hypertension pulmonaire

Abstract : Pulmonary perturbation is a rare and serious pathology resulting from obstruction of the pulmonary arteries and causing right cardiac dysfunction, characterized by ischemia. It is this cardiac dysfunction that conditions the survival of patients.The goal of this thesis work was to develop a cell therapy to support the right ventricle and thus prolong the survival of patients.Cell therapy with endothelial progenitor cells, capable of inducing and participating in angiogenesis, has been administered intracoronally, intracardiacally and via a patch in a porcine model of pulmonary hypertension.We found improvement in right heart function, increased capillary density, and decreased hypertrophy following intracoronal administration. In contrast, injections of cells into the right ventricle revealed an increase in capillary density in a localized manner but failed to improve cardiac function. Finally, patch administration did not allow cell migration into the right ventricle. In conclusion, intracoronal injection gives encouraging preclinical results by improving the function of the right ventricle in an animal model of pulmonary hypertension. These results are to be confirmed on other models and are to be completed by detailed mechanistic studies.
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https://theses.hal.science/tel-02388504
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Submitted on : Monday, December 2, 2019 - 1:08:34 AM
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  • HAL Id : tel-02388504, version 1

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Fanny Loisel. Potentiel thérapeutique des progeniteurs endothéliaux dans le traitement de la défaillance ventriculaire droite secondaire à l'hypertension pulmonaire. Cardiologie et système cardiovasculaire. Université Paris Saclay (COmUE), 2019. Français. ⟨NNT : 2019SACLS023⟩. ⟨tel-02388504⟩

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