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                <term xml:lang="en">Cyclopropyl</term>
                <term xml:lang="en">Ynamide</term>
                <term xml:lang="en">Cyclization</term>
                <term xml:lang="en">Enamide</term>
                <term xml:lang="en">Cyclobutyl</term>
                <term xml:lang="en">Palladium catalysis</term>
                <term xml:lang="en">Radical</term>
                <term xml:lang="fr">Ynamide</term>
                <term xml:lang="fr">Catalyse au palladium</term>
                <term xml:lang="fr">Cyclisation</term>
                <term xml:lang="fr">Énamide</term>
                <term xml:lang="fr">Cyclobutyle</term>
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              <p>This thesis has mainly focused on the development of new methods towards the synthesis of highly valuable nitrogen-containing heterocycles starting from either ynamides or their relatives, in which a radical-mediated intramolecular cyclization of ynamides was eventually developed for the synthesis of a series of N-heterocycles, such as pyrrolidine, piperidine, azepane, pyrazolidine and hexahydropyridazine derivatives. Moreover, by using both N-cyclopropyl enamides and N-cyclobutyl enesulfonamides as substrates, two palladium catalyzed cyclizations involving a rarely reported intramolecular secondary C(sp3)-H alkenylation process were accomplished to give the corresponding 1,4-dihydropyridines and cyclobutyl-fused pyrrolidines, respectively.</p>
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              <p>Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hétérocycles azotés, à partir d’ynamides ou énamides. Dans un premier temps, nous nous sommes intéressés à une réaction de cyclisation intramoléculaire radicalaire permettant la synthèse d’une série d’hétérocycles azotés tels que des pyrrolidines, pipéridines, azépanes, pyrazolidines et hexahydropyridazines. Dans un second temps, nous avons étudié deux cyclisations catalysées au palladium faisant appel à un processus intramoléculaire d’alcénylation de C(sp3)-H de N-cyclopropyl énamides et de N-cyclobutyl énesulfonamides. Cette transformation conduit à des 1,4-dihydropyridines et des pyrrolines fusionnées à un cyclobutane.</p>
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