High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation. - Institut Fédératif des Neurosciences de Lyon Access content directly
Journal Articles Journal of Neuroimmunology Year : 2008

High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation.

Abstract

Collapsin Response Mediator Protein (CRMP)-2 is involved in T-cell polarization and migration. To address the role of CRMP2 in neuroinflammation, we analyzed its involvement in lymphocyte recruitment to the central nervous system in mouse infected with neurotropic and non-neurotropic virus strains (RABV, CDV). A sub-population of early-activated CD69+CD3+ T lymphocytes highly expressing CRMP2 (CRMP2hi) peaked in the blood, lymph nodes and brain of mice infected with neurotropic viruses, and correlated with severity of disease. They displayed high migratory properties reduced by CRMP2 blocking antibody. These data point out the potential use of CRMP2 as a peripheral indicator of neuroinflammation.

Domains

Virology
Fichier principal
Vignette du fichier
JNeuroimmunolVuaillat.pdf (4.27 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

pasteur-00229867 , version 1 (31-01-2008)

Identifiers

Cite

C. Vuaillat, M. Varrin-Doyer, A. Bernard, I. Sagardoy, S. Cavagna, et al.. High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation.. Journal of Neuroimmunology, 2008, 193 (1-2), pp.38-51. ⟨10.1016/j.jneuroim.2007.09.033⟩. ⟨pasteur-00229867⟩
187 View
435 Download

Altmetric

Share

Gmail Facebook X LinkedIn More