Loading...
Dernières publications
-
Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
-
Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
-
Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
-
Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
131
Publications avec texte intégral
Open Access
52 %
Mots clés
RNA splicing
Mouse models
CRISPR/Cas9
Lc3
Cell penetrating peptide
Cell model
Alternative splicing
Hypoxia
Neuron
CTG repeat instability
DMPK
Brain
Cell culture model
RNA interference
Glucocorticoid-receptor
ARN
RNA biology
Duchenne muscular dystrophy
GABA
AAV
Acetylcholinesterase knockout mouse
Humans
Dystrophie Myotonique
Glial cells
CTG repeats
In vivo
Cardiac muscle
Gene editing
CTG repeat contractions
Gene therapy
Dilated cardiomyopathy
Oligodendrocytes
Fibrosis
Glutamate
Skeletal muscle
Long read sequencing
Genotype phenotype correlation
Myelin
Myotonic dystrophy
Quantitative microdialysis
Dystrophie myotonique
ACETYLCHOLINESTERASE
Intermediate filament
Glucocorticoids
Antisense oligonucleotides
Oligodendrocyte
Astrocytes
Animals
Brain dysfunction
Myostatin
Exercise
Motoneuron
BIOLOGIE MOLECULAIRE
Desmin
Mice
Dystrophin
Autophagy
Thérapie génique
Transgenic mouse model
CRISPRi
Trinucleotide repeat expansion
Diaphragm
Muscular dystrophy
Myotonic dystrophy mouse models
Central nervous system
Myotonic Dystrophy type 1
Dynamin 2
PacBio
Knockout
Astrocyte
Gene Therapy
Aging
Myotonic Dystrophy Type 1
DM1
Heart failure
DMSXL mice
Trinucleotide Repeat Expansion
Acetylcholinesterase deficiency
Cytoskeleton
Heart
KNOCKOUT MICE
Transcriptomics
Mouse model
Acute coronary syndrome
Muscle
MBNL
Therapy
Antisense oligonucleotide
Expression
Maximal force
Centronuclear myopathy
CMS
Transgenic mouse
Myotonic dystrophy type 1
Male
GSK3
CONGENITAL MYATHENIC SYNDROME
PCR
Myotonic Dystrophy
Exercice