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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
132
Publications avec texte intégral
Open Access
52 %
Mots clés
ACETYLCHOLINESTERASE
Dynamin 2
Myotonic Dystrophy type 1
Mouse model
GABA
Dilated cardiomyopathy
AAV
Acetylcholinesterase knockout mouse
Skeletal muscle
CTG repeat contractions
CRISPRi
Myotonic Dystrophy Type 1
Antisense oligonucleotide
Humans
CTG repeats
Alternative splicing
Dystrophin
Desmin
Cell model
Neuron
Myotonic dystrophy type 1
Dystrophie Myotonique
Transgenic mouse model
CMS
Maximal force
Heart failure
Cardiac muscle
Oligodendrocytes
Cell penetrating peptide
Dystrophie myotonique
Quantitative microdialysis
Antisense oligonucleotides
Long read sequencing
RNA interference
Duchenne muscular dystrophy
Myelin
Glucocorticoid-receptor
Muscular dystrophy
CONGENITAL MYATHENIC SYNDROME
Knockout
In vivo
Acute coronary syndrome
Transcriptomics
Astrocyte
ARN
KNOCKOUT MICE
Hypoxia
Centronuclear myopathy
Glial cells
Fibrosis
Lc3
Myostatin
MBNL
Autophagy
PacBio
Therapy
Myotonic dystrophy
Exercise
Muscle
Myotonic dystrophy mouse models
Cell culture model
Gene editing
Exercice
Gene therapy
PCR
Cytoskeleton
Thérapie génique
Motoneuron
Glutamate
Astrocytes
Transgenic mouse
Male
DM1
Heart
Aging
Diaphragm
Mouse models
Gene Therapy
DMSXL mice
Genotype phenotype correlation
Animals
Central nervous system
Brain dysfunction
CRISPR/Cas9
RNA splicing
Brain
Mice
CTG repeat instability
BIOLOGIE MOLECULAIRE
Acetylcholinesterase deficiency
DMPK
GSK3
Expression
Trinucleotide repeat expansion
Glucocorticoids
Intermediate filament
Oligodendrocyte
Myotonic Dystrophy
RNA biology
Trinucleotide Repeat Expansion