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Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse

Abstract : The aim of this work was to evaluate polylactic acid- Bioglass® composites for bone repair applications. Bioglass being too brittle to be used alone for load bearing applications, our strategy was to incorporate bioactive Bioglass® particles into a bioresorbable polymer matrix processed by conventional manufacturing techniques. The composite were processed by injection moulding from granules prepared by a solvent route. The composites exhibit higher Young modulus but lower strength and strain to failure than polymer alone. This is attributed to a decrease of molecular weight of the polymer matrix during the different steps of the process. Another processing method (hot pressing) was used to limit the drop in molecular weight of the polymer matrix: it leads to higher mechanical properties. Therefore, a careful control of the Polymer degradation may insure better mechanical properties and a better control of the degradation rate in vivo. The bioactivity of composites with 20, 30, 50 Wt. % of Bioglass® was a assessed by immersion in simulated body fluid. All the composites are bioactive, and all the more since the Bioglass® content is large. On the other side, the degradation of composites with a Bioglass® content of 50 wt. % is very rapid. Biological evaluation was conducted in vitro and in vivo. Osteoblast cell cultures and in vivo evaluation in rabbits demonstrate that polylactic acid - Bioglass® composites are biocompatible and osteoconductive. Such composites may therefore be a good option for bone repair applications in the future.
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Submitted on : Friday, February 10, 2012 - 11:07:26 AM
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  • HAL Id : tel-00668698, version 1

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Nathalie Ginsac. Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse. Autre. INSA de Lyon, 2011. Français. ⟨NNT : 2011ISAL0020⟩. ⟨tel-00668698⟩

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