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Inflammation cutanée et borréliose de Lyme : étude in vitro des interactions entre les cellules résidentes de la peau et Borrelia

Abstract : We studied the role of the skin innate immunity during the transmission of Borrelia (the infectious agent of Lyme borreliosis) by its vector, a hard tick belonging to the genus Ixodes. We showed that tick saliva and its protein Salp15 both inhibate Borrelia-induced inflammatory reaction of keratinocytes. The antialarmin effect of tick saliva ensure a favorable environment for Borrelia. We also showed that Borrelia induce a strong inflammatory response in dermal fibroblasts. We also demonstrate a dose-dependent lytic effect of tick salivary gland extracts on dermal fibroblasts and that this cytotoxic effect was of proteinaceous nature and not related to Salp15. These results indicate that dermal fibroblasts could be considered as central mediators in immune cell recruitment to the skin site of Borrelia invasion.
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Submitted on : Monday, November 26, 2012 - 10:42:23 AM
Last modification on : Thursday, August 23, 2018 - 9:20:05 AM
Long-term archiving on: : Wednesday, February 27, 2013 - 3:42:38 AM

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  • HAL Id : tel-00757050, version 1

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Frédéric Schramm. Inflammation cutanée et borréliose de Lyme : étude in vitro des interactions entre les cellules résidentes de la peau et Borrelia. Microbiologie et Parasitologie. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAJ026⟩. ⟨tel-00757050⟩

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