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Recherche de biomarqueurs des cellules propagatrices de glioblastome : étude de la signalisation calcique et du protéome membranaire

Abstract : Glioblastomas are malignant tumor of poor prognosis. Therapeutic failure might be supported by cancer stem cells (CSCs); characterization of these cells and biomarkers identification are of most importance. Calcium controls numerous cellular process; beyond major elements of calcium signaling, Calmodulin (CaM) is involved in different pathologies and tumors, and is a powerful regulator of cell physiological state. CaM interacts with a plethora of proteins involved in cell calcium homeostasis regulation. We aimed at identifying and characterizing CaM antagonists, capable of differentially inhibiting these interactions. The use of these antagonists in calcium homeostasis disturbance led to the identification of a characterized marker of glioblastomas CSCs. In another approach, the comparative study of glioblastomas CSCs membrane proteome uncovered the overexpression of differentiation clusters and proteins involved in calcium signaling. These proteins are potential molecular biomarkers for glioblastomes CSCs.
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Submitted on : Thursday, December 20, 2012 - 11:07:27 AM
Last modification on : Monday, December 13, 2021 - 1:58:01 PM
Long-term archiving on: : Sunday, December 18, 2016 - 7:08:39 AM

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  • HAL Id : tel-00767650, version 1

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Emilie Audran. Recherche de biomarqueurs des cellules propagatrices de glioblastome : étude de la signalisation calcique et du protéome membranaire. Biochimie, Biologie Moléculaire. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAJ046⟩. ⟨tel-00767650⟩

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