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Étude physico-chimique, fonctionnalisation et applications des films de polysaccharides

Abstract : In France, 5 % of the hospitalized patients develop a hospital-acquired infection. To fight this problem, we developed a new kind of biocompatible films based on polysaccharides , which can be functionalized, built by spraying process. Derived from layer-by-layer dipping of polyanions and polycations, spraying let to spare time. First, we focused on the complexation of Chitosane and hyaluronic acid. We investigated the complexation and multilayers coating on this type of complexes. Next, we studied the buildup of polysaccharide films by alternate and simultaneous spray. Biocompatibility of the polysaccharide films was tested to validate their use as biomaterial coatings. Eventually, we investigated their functionalization. Their activityx against different pathogens and their biocompatibility were tested.This study shows that it is possible to build polysaccharide films by spraying methods and to render these films active against different pathogens by grafting antimicrobial peptides.
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Gwenaëlle Cado. Étude physico-chimique, fonctionnalisation et applications des films de polysaccharides. Autre. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAE024⟩. ⟨tel-00859416⟩

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