Skip to Main content Skip to Navigation
New interface
Theses

Imagerie des faisceaux de fibres et des réseaux fonctionnels du cerveau : application à l'étude du syndrome de Gilles de la Tourette

Abstract : The objective of this thesis is to identify and characterize human anatomical and functional cortico-subcortical loops, using data from resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A loop is a set of cortical, subcortical and cerebellar regions that interact to perform or prepare for a task.We first aim to identify cortico-subcortical functional networks from resting-state fMRI data. We propose a robust statistical method that separates the analysis of cortical regions from that of subcortical structures. A spatial independent component analysis is first performed on individual cortical regions, followed by a hierarchical classification. The associated subcortical regions are then extracted by using a general linear model, the regressors of which contain the dynamics of the cortical regions, followed by a random-effect group analysis. The proposed approach is assessed on two different data sets. An immunohistochemical subcortical atlas is then used to determine the sensorimotor, associative or limbic function of the resulting networks. We finally demonstrate that anatomy is a support for function in healthy subjects.The last part is devoted to the study of the Gilles de la Tourette syndrome, thought to be due to adysfunction of cortico-subcortical loops. Firstly, cortico-subcortical functional loops are characterized using metrics such as integration and graph theory measures, showing differences in terms of connectivity between adult patients and healthy volunteers. Secondly, we show that the cortico-subcortical functional loops in patients are supported by the underlying anatomy.
Complete list of metadata

Cited literature [163 references]  Display  Hide  Download

https://theses.hal.science/tel-00980572
Contributor : ABES STAR :  Contact
Submitted on : Friday, April 18, 2014 - 11:49:42 AM
Last modification on : Sunday, June 26, 2022 - 10:03:02 AM
Long-term archiving on: : Monday, April 10, 2017 - 3:34:28 PM

File

VA2_MALHERBE_CAROLINE_28032012...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00980572, version 1

Citation

Caroline Malherbe. Imagerie des faisceaux de fibres et des réseaux fonctionnels du cerveau : application à l'étude du syndrome de Gilles de la Tourette. Autre [cond-mat.other]. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA112057⟩. ⟨tel-00980572⟩

Share

Metrics

Record views

319

Files downloads

2746