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Conséquences de l'exposition de l'insecte modèle Aedes aegypti aux polluants des eaux de surface : Des mécanismes moléculaires à la dynamique des populations

Abstract : Human activities daily release a wide variety of chemicals in the environment. Populations of aquatic organisms are thus exposed to pollutants throughout their life cycle, raising the question of the impacts of these pollutants on aquatic ecosystems. In this work, we study life history traits of populations of Aedes aegypti mosquito exposed to three pollutants: ibuprofen, bisphenol A and benzo[a]pyrene. Our observations reveal life history traits alterations likely to affect Aedes aegypti populations dynamic at environmental concentrations, more particularly showing the importance of transgenerational effects in those modifications. An integrative approach combining transcriptomic, metabolomic and hormonal studies on several phases of the life cycle of individuals exposed to ibuprofen was adopted in order to deepen the understanding of impacts of this pharmaceutical on individuals. This approach reveals a mechanism of action similar to the pharmacological mode of action on vertebrates of this pharmaceutical. Those perturbations are associated with crucial changes in the physiological state of their progeny. The identified modifications include ecdysone signalling potentialization and stress response mechanism over-representation, leading to a faster development and an increased tolerance to starvation of this progeny. Overall, our approach highlights the importance of taking into account the all life cycle of organisms, including their progeny, in ecotoxicological risk assessment.
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https://theses.hal.science/tel-01419174
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Submitted on : Monday, December 19, 2016 - 1:03:50 AM
Last modification on : Friday, March 25, 2022 - 9:41:21 AM
Long-term archiving on: : Tuesday, March 21, 2017 - 1:09:04 PM

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  • HAL Id : tel-01419174, version 1

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Sophie Prud'Homme. Conséquences de l'exposition de l'insecte modèle Aedes aegypti aux polluants des eaux de surface : Des mécanismes moléculaires à la dynamique des populations. Toxicologie. Université Grenoble Alpes, 2015. Français. ⟨NNT : 2015GREAV030⟩. ⟨tel-01419174⟩

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