The Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granitoids in the Nanling Range were mainlyderived from non-simultaneous partial melting of the mafic amphibolitic rocks in the lower crust and themuscovite-rich metasedimentary rocks in the upper-middle crust, respectively. The fertile sources in theNanling Range are beneficial to the formation of Cu-Pb-Zn and W deposits during Middle-Late Jurassic.The lower-crust origin of the Cu-Pb-Zn-bearing granodiorites is further demonstrated by the dioriticmicrogranular enclaves in the Tongshanling granodiorite which are reworked restite enclaves derivedfrom partial melting of the mafic amphibolitic source. The Cu and Zn associated with these intrusionswere most probably released from the mafic amphibolitic lower crust by partial melting, whereas, Pb wasextracted from the upper crust by ascending granodioritic magmas. The emplacement of these orebearinggranitoid magmas may have a structural connection with the subsequent polymetallicmineralization in some way. For instance, the exoskarn and sulfide-quartz veins in the Tongshanling Cu-Pb-Zn deposit are evidently controlled by magma emplacement-induced wall-rock deformation. Thedifferent mineralization types and ore deposits in the Tongshanling Cu-Mo-Pb-Zn-Ag ore district aregenetically linked together in the same skarn system as the productions of evolution and zonation. TheWeijia granite was crystallized from a F-rich and water-saturated magma. The key factors controlling theoccurrence of unusual magnesian skarn W mineralization during Late Jurassic in the Nanling Rangemainly include a W enriched metasedimentary source, a fluorine-rich magma, a strong crystalfractionation, and a fluorine-rich hydrosaline melt