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Etudes des performances d'un détecteur dédié au contrôle balistique lors des traitements d'hadronthérapie par simulation Monte-Carlo

Abstract : The use of ion beams (protons or light ions) makes it possible to obtain, during treatment, a localised energy deposit at the end of the treatment in a small area of space. The preferred targets for this therapy are "radioresistant" tumours or treatments requiring very precise ballistics, due to the presence of high-risk organs close to the tumour. However, as the determination of the ion path and thus the delivered dose is dependent on quantities that are difficult to measure precisely, large safety margins must be taken into account when designing the treatment plan. Consequently, it is necessary to set up an efficient ballistic control system in order to guarantee the quality of the treatment. One of the possibilities for ballistic control is based on the real-time measurement of the spatial distribution of positron-emitting radionuclides produced by the fragmentation reaction between the projectile and the target and thus on the coincident detection of two photons. For this purpose, a first prototype called Large Area Pixelized Detector (LAPD) was designed and built at the Clermont Physics Laboratory. Initially, this work allowed to compare the predictions of two hadronic models implemented in Geant4 with experimental measurements performed by Dendooven et al. at 55 MeV. We then focused on characterizing the performance of the LAPD and determining its potential when used in a clinical beam. For this purpose, we developed a Monte-Carlo simulation dedicated to understand the associated physics, the detector and the experiments carried out on 65 MeV proton beam at the Institut Mediterranéen de Protonthérapie (IMPT) in Nice. Finally, as the LPAD will eventually be coupled with a high-bandwidth acquisition system (μTCA) allowing the sending and processing of the measured data in real time, we have made a study of the performances expected on the PROTEUS ONE line of the IMPT at 120 and 230 MeV.
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Submitted on : Thursday, August 27, 2020 - 3:33:14 PM
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  • HAL Id : tel-02923922, version 1


Arthur Bongrand. Etudes des performances d'un détecteur dédié au contrôle balistique lors des traitements d'hadronthérapie par simulation Monte-Carlo. Physique Médicale []. Université Clermont Auvergne [2017-2020], 2019. Français. ⟨NNT : 2019CLFAC094⟩. ⟨tel-02923922⟩



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