This PhD work investigates the complex links between urban physical processes, through the development of coupled simulation platforms to account simultaneously for building energy demand, individual or district energy systems, and urban microclimate. The spatial and temporal scales correspond to urban neighborhoods under explicit geometries, and annual simulations respectively. Several coupling strategies have been evaluated, regarding thermal efficiency indicators, and the determination of the diversity of coupled phenomena. The synchronous coupling schemes can effectively assess the dynamical interactions between buildings and the local microclimate. Nevertheless, the coupling variable is sensitive to the thermal properties of the building. The simplification of the urban canopy layer to a single-node description reveals significant variability in building energy demand. Besides, the developed model has been employed to assess the thermal performance of an urban neighborhood in La Rochelle. The transition from local energy systems to the district energy network eliminates anthropogenic heat from buildings, and improves the outdoor thermal comfort conditions, acting as a local heat island mitigation strategy. However, it is associated with an energy penalty due to the ground losses of the piping circuit. This energy penalty is amplified when a passive mitigation strategy (cool materials) is implemented concurrently.