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Dissection des fonctions régulatrices des lymphocytes iNKT en situation auto-immune dans le modèle de la souris NOD

Abstract : NKT cells are endowed with potent regulatory functions during the immune response, rendering their investigation in immunopathological situations particularly relevant. During my PhD studies I have examined the impact of iNKT cell deficiencies in NOD mice, using two autoimmune settings, namely type 1 diabetes and ConA-induced hepatitis. NOD mice develop insulin-dependent diabetes spontaneously. Their iNKT cell population is reduced, and even though it does not ensure protection against diabetes as such, it constitutes a sensitive therapeutic target of a-GalCer, which prevents the onset of the disease. On the other hand, we found that NOD mice were less prone to ConA-induced hepatitis than wild-type mice and provide evidence for a deleterious role of spleen- rather than liver-derived IL-4 in this pathology. Finally, we demonstrate that IL-12, acknowledged for its capacity to exacerbate the disease, can directly enhance IL-4 production by spleen iNKT cells. Taken together, our study reveals new therapeutic targets for immuno-intervention and highlights once again the contrasting biological effects of iNKT cells, both beneficial and detrimental.
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https://theses.hal.science/tel-00084227
Contributor : Catherine Slama Connect in order to contact the contributor
Submitted on : Thursday, July 6, 2006 - 11:08:53 AM
Last modification on : Saturday, June 25, 2022 - 8:45:25 PM
Long-term archiving on: : Friday, November 25, 2016 - 11:14:53 AM

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  • HAL Id : tel-00084227, version 1

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Ren Zhu. Dissection des fonctions régulatrices des lymphocytes iNKT en situation auto-immune dans le modèle de la souris NOD. Immunologie. Université René Descartes - Paris V, 2006. Français. ⟨NNT : ⟩. ⟨tel-00084227⟩

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