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Activité physique et produits dérivés du soja : intérêts dans la prise en charge du stress oxydant associé au diabète de type 1

Abstract : Oxidant stress (OS) is well known to contribute to the onset and the development of diabetic complications. OS mainly result from marked rises in blood glucose level. Insulin treatment is required to keep patients alive, but fails to prevent long term complications progression, which result from hyperglycemic induced OS.In healthy people, diet and/or physical activity succeed to significantly reduce OS. Physical activity exhibit moreover glucoregulatory properties.Consequently, the aim of this thesis was to determine if combination of some therapeutic managements could better counteract OS, acting by complementary mechanisms, and so demonstrating additional effects. We used different protocols of supplementation, insulin therapy and endurance training to achieve these objectives. Our research demonstrated the value of soy derived compound, FSP, in management of diabetes-induced OS. We highlighted the abillity of insulin therapy and endurance training to improve hyperglycemic-induced OS, by differents mechanisms. Combination of both in therapeutic management of diabetes allow then to improve each other
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Submitted on : Monday, January 14, 2013 - 4:13:02 PM
Last modification on : Thursday, March 31, 2022 - 3:40:24 AM
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  • HAL Id : tel-00775870, version 1

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Ludivine Malardé. Activité physique et produits dérivés du soja : intérêts dans la prise en charge du stress oxydant associé au diabète de type 1. Education. Université Rennes 2, 2012. Français. ⟨NNT : 2012REN20055⟩. ⟨tel-00775870⟩

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