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Estimation 3D conjointe forme/structure/mouvement dans des séquences dynamiques d’images : Application à l’obtention de modèles cardiaques patients spécifiques anatomiques et fonctionnels

Christopher Casta 1 
1 MOTIVATE - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé : 139739
Abstract : In this thesis, we are interested in two complementary goals. First, we have improved the Dynamic Deformable Elastic Template (DET) model, developed at Creatis, for the semi-automatic extraction of the anatomy and cardiac motion. The performance of the method was assessed on a database consisting in 45 patients and yielded fairly accurate results. However, it experienced difficulties when dealing with very large thickening throughout the cardiac cycle. Thus, different type of constraints were integrated to the DET model in order to improve robustness and accuracy : local or dense prescribed displacements, deformations directionally constrained by the fibres. These constraints are evaluated on simulated and real human data, in both cine and tagged MR images. A methodology has also been developed in order to extract and statistically analyse myocardial fibre strain. This work was done in collaboration with a team at the Auckland Bioengineering Institute in New Zealand. A finite elements biomechanical model integrates the principle direction of fibres in the left ventricle from Diffusion Tensor MRI acquisitions on ex vivo human hearts and motion from tagged MRI sequences. Fibre strain and its variation throughout the cardiac cycle were estimated. Variability in fibre strain is statistically studied by joining DT-MRI and tagged MRI databases.
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Christopher Casta. Estimation 3D conjointe forme/structure/mouvement dans des séquences dynamiques d’images : Application à l’obtention de modèles cardiaques patients spécifiques anatomiques et fonctionnels. Autre. INSA de Lyon, 2012. Français. ⟨NNT : 2012ISAL0117⟩. ⟨tel-00835830⟩

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