Skip to Main content Skip to Navigation
New interface
Theses

Etudes d'auto-assemblages polydiacétylèniques et applications biologiques

Abstract : The hydrophobic/hydrophilic duality of amphiphilic molecules is at the origin of their selfassembly in solution, into many supramolecular structures such as micelles. This thesis presents the formation, characterization and study of new photopolymerizable diacetylenic micelles. The first part describes the synthesis of new cationic micelles and the study of theiruse as gene transfer agent. In the second part, our work presents the study of polydiacetylene micelles, bearing polar heads octaétylèneglycol as potential drug delivery system. The encapsulation properties of these micelles were first evaluated in the presence of a fluorescent fullerene derivative. Then, the incorporation of a membrane probe in their lipophilic shell has allowed a study of their in vitro delivery properties. Finally a study of their in vivo biodistribution was also carried out by single photon emission tomography through the chelation of a radioactive isotope on micelle surface. Finally the last part presents theanalysis of two new tubularself-assemblies, obtained during our work.
Document type :
Theses
Complete list of metadata

https://theses.hal.science/tel-00855285
Contributor : ABES STAR :  Contact
Submitted on : Thursday, August 29, 2013 - 11:20:55 AM
Last modification on : Monday, December 13, 2021 - 1:54:01 PM

File

Morin-Picardat_Emmanuelle_2012...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00855285, version 1

Collections

Citation

Emmanuelle Morin Morin-Picardat. Etudes d'auto-assemblages polydiacétylèniques et applications biologiques. Autre. Université de Strasbourg, 2012. Français. ⟨NNT : 2012STRAF063⟩. ⟨tel-00855285⟩

Share

Metrics

Record views

137

Files downloads

37