In this manuscript, we consider structured machine learning problems and consider more precisely the ones involving sequential structure. In a first part, we consider the problem of similarity measure learning for two tasks where sequential structure is at stake: (i) the multivariate change-point detection and (ii) the time warping of pairs of time series. The methods generally used to solve these tasks rely on a similarity measure to compare timestamps. We propose to learn a similarity measure from fully labelled data, i.e., signals already segmented or pairs of signals for which the optimal time warping is known. Using standard structured prediction methods, we present algorithmically efficient ways for learning. We propose to use loss functions specifically designed for the tasks. We validate our approach on real-world data. In a second part, we focus on the problem of weak supervision, in which sequential data are not totally labeled. We focus on the problem of aligning an audio recording with its score. We consider the score as a symbolic representation giving: (i) a complete information about the order of events or notes played and (ii) an approximate idea about the expected shape of the alignment. We propose to learn a classifier for each note using this information. Our learning problem is based onthe optimization of a convex function that takes advantage of the weak supervision and of the sequential structure of data. Our approach is validated through experiments on the task of audio-to-score on real musical data.