With the increase in air traffic, surely a question of flight efficiency (delays), environment impact and safety arise. This calls for improvements in accuracy of spatial and temporal trajectory tracking. The first main objective of this thesis is to contribute to the synthesis of a space-indexed nonlinear guidance control law for transportation aircraft presenting enhanced tracking performances and to explore the performances and feasibility of a flight guidance control law which is developed based on a space-indexed reference to track a 3D+T reference trajectory using nonlinear dynamic inversion control. The proposed guidance control law present reduced tracking errors and able to meet more easily overfly time constraints. Before presenting the main approaches for the design of the 3D+T guidance control laws; the modern flight guidance and flight dynamics of transportation aircraft, including explicitly wind components are first introduced. Then, a description of the current and modern air traffic organization including the organization of air traffic in high density flow will be shown and this will lead to a description of the Airstreams concept. This proposed concept is to organize main traffic flows in congested airspace along airstreams which are characterized by a three dimensional (3D) common reference track (ASRT). Finally, a scenario to perform basic maneuvers inside the airstream following a 3D+T trajectory using a common space-indexed will be developed and will be used to illustrate the traffic management along an airstream.