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Pathogènes parodontaux, marqueurs inflammatoires et maladies cardiovasculaires

Abstract : Periodontitis is an inflammatory disease affecting tissues surrounding the teeth,and is caused by a dysregulation between periodontal pathogens and the host response.Numerous studies observed an association between periodontal pathogens, clinical signsof periodontitis, antobodies against periodontalpathogens, and cardiovascular events oratherosclerosis. The first cross-sectional studywas conducted among 457 adults aged 52+from ARIC cohort. We investigated therelationship between severe periodontitis andmodifications in the retinal microcirculation. Previous studies found increase in retinalvenular diameters predicted futurecardiovascular events. We observed asignificant and independent increase in retinalvenular diameters with severe periodontitis. Ina second cross-sectional study conductedamong 593 adults aged 55+ from INVESTcohort, we investigated the relationshipbetween the presence of periodontal pathogensand phospholipases A2 activities, enzymeswhich are associated with future cardiovascularevents. We observed participants with higherrelative concentrations of periodontalpathogens had higher secretory phospholipaseA2 activity. Future prospective studies areneeded to explore the impact of inflammatorymarkers and first microcirculatory alterations inthe association between periodontitis and futurecardiovascular events.
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Submitted on : Wednesday, October 19, 2016 - 5:00:09 PM
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Adrien Boillot. Pathogènes parodontaux, marqueurs inflammatoires et maladies cardiovasculaires. Médecine humaine et pathologie. Université Paris Saclay (COmUE), 2016. Français. ⟨NNT : 2016SACLV036⟩. ⟨tel-01384341⟩

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