This dissertation deals with the co-construction of meaning in interaction and the ways in which conversationalists exhibit their interpretative processes. The focus of this study is the process of explicitation, i.e. the process through which an informational content becomes explicit in conversation. By offering a multi-level analysis of conversational sequences engaged in this practice, the study approaches the co-construction of meaning from the point of view of informational transformation and inference.The analyses presented here have been conducted on a corpus of spoken French in interaction, within the setting of informal encounters between friends around a meal or a drink. The explicitation sequence is defined as a conversational pattern where an inference is being submitted for confirmation. Starting from a collection of these sequences, this study offers a twofold approach: that of conversation analysis, and that of modeling of the conversational sequence. The practice of making a content explicit is here being explored according to three analytical lines: (a) the sequential analysis, focusing on the deployment of the explicitation sequence and its components; (b) the analysis according to a device elaborated by means of modeling information management in these sequences; and (c) the analysis of the linguistic designs used when exhibiting the inference. One of themain challenges of the present study is that of a proposition of a conversationalist model, dealing with information management and its enforcement through analysis of talk in interaction.