Homogeneous asymmetric gold catalysis plays a central role in synthetic chemistry. In the past decades, chemists have unremittingly explored this field and have designed many effective strategies toward enantioselective methods. Among others, the so-called Asymmetric Counteranion-Directed Catalysis (ACDC), introduced in gold chemistry by D. Toste in 2007, has become a powerful approach, leading to excellent reactivity and enantioselectivity notably in intramolecular reactions. The ACDC strategy also showed major limitations since the phosphate-gold ion pair may be too loose and flexible to shape a suitable chiral pocket around the reactive center.In this context, in order to overcome some of the limitations of the ACDC approach, we have introduced a new design for chiral gold catalysts, based on bifunctional phosphine-phosphoric acid ligands. The phosphine group is expected to coordinate the metal center, while the tethered phosphate will play the role of counteranion in the cationic gold complex. Tethering of the two functions is expected to increase the rigidity and the geometrical constraints in the key intermediates of enantioselective catalytic processes, thereby favoring the enantioselectivity. This unprecedented strategy is called ‘Tethered Counterion-Directed Catalysis’ (TCDC).Based on this new catalyst design, we have synthesized a series of six Au(I) complexes bearing bifunctional phosphine-phosphoric acid ligands, with various chains connecting the two functions. The phosphoric acid units are based on either (S)-BINOL or (R)-SPINOL backbones, i.e. well-known chiral scaffolds that should create suitable chiral environments.The new catalysts have been applied successfully in many reactions, such as a series of tandem cyclization/nucleophilic additions. The targeted reactions convert cyclic -ethynyl-enones into bicyclic furanes functionalized by the incoming nucleophile (amines, indoles, nitrones, alcohols etc.). The newly designed Au(I) catalysts demonstrated unprecedented levels of catalytic activity, enabling the use of very low catalyst loadings (up to 0.2 mol%). Moreover, they enabled a silver-free protocol to be implemented, which is an important breakthrough in gold catalysis that is often hampered by silver side-effects. The catalysts also provided excellent enantioselectivities, with enantiomeric excesses >90% in most cases.Overall, this PhD work allowed to validate the working hypothesis by demonstrating the relevance of the TCDC approach in enantioselective gold(I) catalysis. Meanwhile, the excellent results obtained so far offer huge synthetic perspectives.