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Une approche rationnelle de la chimiothérapie : histoire des antimétabolites (1935-1955)

Abstract : In 1940, the British biochemist Donald Woods put forward an explanation of the mode of action of the new antibacterial sulfa drugs, competitive inhibition. His colleague, Paul Fildes, developed this work into a new approach to chemotherapy, which he qualified as a rational programme for drug discovery. This dissertation explores the impact of the theory of antimetabolites, as it came to be known, in biochemical and pharmaceutical research. The first part traces its development in the context of the British school of biochemistry and its further expansion in the United States following parallel research on vitamins. The second part deals with the construction of two distinct research programmes dedicated to antimetabolites, each one illustrating a different way of following this rational approach and their varying consequences. The first one is a modest collaboration between the biochemist Henry McIlwain and the Glaxo pharmaceutical company during the war in the United Kingdom. The second one corresponds to the establishment of George Hitchings' and Gertrude Elion's programme at Burroughs Wellcome in the United States, often considered as the origin of today's rational drug design. The theory of antimetabolites simultaneously embodied both the ambition of attaining specific chemotherapies, and a set of practices in day-to-day laboratory work
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Submitted on : Thursday, April 6, 2017 - 1:05:07 PM
Last modification on : Tuesday, September 13, 2022 - 2:46:07 PM
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  • HAL Id : tel-01502916, version 1


Thibaut Serviant-Fine. Une approche rationnelle de la chimiothérapie : histoire des antimétabolites (1935-1955). Histoire, Philosophie et Sociologie des sciences. Université de Lyon, 2016. Français. ⟨NNT : 2016LYSE1271⟩. ⟨tel-01502916⟩



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